Results 121 to 130 of about 19,083 (252)

Risk of Serious Adverse Events and Death With Low‐Dose Methotrexate Versus Hydroxychloroquine in Adults Receiving Dialysis

Seminars in Dialysis, EarlyView.
ABSTRACT Background Several case reports have linked low‐dose methotrexate to serious adverse events, including death, in dialysis patients. We compared the risk of serious adverse events in dialysis patients initiating low‐dose methotrexate versus hydroxychloroquine.
Flory T. Muanda, Peter G. Blake, Matthew A. Weir, Fatemeh Ahmadi, Mohammad Ali Omrani, Sheikh S. Abdullah, Eric McArthur, Jessica M. Sontrop, Brad L. Urquhart, Amit X. Garg   +9 more
wiley   +1 more source

Leveraging Administrative Health Data to Capture Rare Adverse Drug Reactions: Identifying Pediatric Patients With Trimethoprim‐Sulfamethoxazole Acute Respiratory Distress Syndrome

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Rare adverse drug reactions (ADRs) are underrecognized and underreported in the electronic medical record (EMR). These events often require clinical review, making systematic identification challenging. The study aim was to develop an approach to prioritize identification and validation of a rare ADR to trimethoprim‐sulfamethoxazole causing ...
Keith Feldman, Jenna O. Miller, Katherine Doane, Laura Loftis, James W. Antoon, Kevin J. Downes, Jennifer L. Goldman   +6 more
wiley   +1 more source

Treating Rheumatoid Arthritis yesterday and today [PDF]

, 2004
Rheumatoid arthritis is a chronic, systemic inflammatory disorder that mainly affects joints. It is the most common form of inflammatory joint disease, and the second commonest joint disease, osteoarthritis being the commonest.
Mallia, Carmel
core  

Financial Toxicity Associated with Biological Medicines: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 81-93, July 2026.
Financial toxicity, defined as the economic burden experienced by patients due to medication and other healthcare costs and their consequences, such as material, psychosocial and behavioral effects, represents a significant concern for individuals receiving biological medicines.
Laura Sara Maria Saarukka, Kamilla Yamileva, Kari Linden, Anniina Simonen, Anna‐Riia Holmström   +4 more
wiley   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Protein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli, Sabino Todisco, Margherita Ortalli, Jairo Alfonso Mendoza‐Roldan, Valeria Scaglione, Maria Noemi Sgobba, Lorenzo Guerra, Federica Belluti, Stefania Varani, Domenico Otranto, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri   +15 more
wiley   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Volume 78, Issue 6, Page 749-760, June 2026.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Positive and Negative Cardiovascular Effects of JAK Inhibitors in Inflammation

ACR Open Rheumatology, Volume 8, Issue 6, June 2026.
Chronic inflammation, characteristic of many autoimmune diseases, such as rheumatoid arthritis (RA), or myeloproliferative neoplasms (MPNs), is an independent driver of accelerated cardiovascular (CV) risk, primarily through proinflammatory cytokines that induce atherosclerosis and endothelial dysfunction.
Aliki Zavoriti, Pierre Miossec
wiley   +1 more source

Mandatory Biological/Targeted Synthetic Disease-Modifying Antirheumatic Drugs Dose Reduction on Risk of Serious Infections in Patients with Rheumatoid Arthritis: A Nationwide Nested Case–Control Study

Biomedicines
Background: We aimed to investigate the risk for a serious infection in rheumatoid arthritis (RA) patients after tapering the dose of biological/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs).
Der-Yuan Chen, Ching-Heng Lin, Hsin-Hua Chen, Yi-Ming Chen, Kuo-Tung Tang   +4 more
doaj   +1 more source

Consenso 2012 da Sociedade Brasileira de Reumatologia para o tratamento da artrite reumatoide

Revista Brasileira de Reumatologia
OBJETIVO: Elaborar recomendações para o tratamento da artrite reumatoide no Brasil. MÉTODO: Revisão da literatura com seleção de artigos baseados em evidência e opinião de especialistas da Comissão de Artrite Reumatoide da Sociedade Brasileira de ...
Licia Maria Henrique da Mota, Boris Afonso Cruz, Claiton Viegas Brenol, Ivanio Alves Pereira, Lucila Stange Rezende-Fronza, Manoel Barros Bertolo, Max Victor Carioca de Freitas, Nilzio Antonio da Silva, Paulo Louzada-Júnior, Rina Dalva Neubarth Giorgi, Rodrigo Aires Corrêa Lima, Geraldo da Rocha Castelar Pinheiro   +11 more
doaj  

Exploring Floristic Diversity and Medicinal Plant Uses in Venda, Limpopo, South Africa

Feddes Repertorium, Volume 137, Issue 2, June 2026.
ABSTRACT Plants have been an important source of medicine for thousands of years. To better understand the current diversity and usage of medicinal plants, floristic studies are essential. This report documents an expedition conducted in the Venda region of Limpopo, South Africa. The study was carried out in Shanzha and surrounding villages, as well as
Gurusamy Manikandan, Iliassou L. Mouafon, David R. Katerere   +2 more
wiley   +1 more source