Case Report: A case of focal segmental glomerulosclerosis in Wilson’s disease induced by penicillamine [PDF]
Frontiers in MedicineWilson’s disease (WD) is a hereditary disorder that impairs copper metabolism. Both WD and its treatment with penicillamine are associated with renal impairment.
Qi Li +3 more
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Safety of penicillamine and trientine in the treatment of Wilson's disease: An analysis of the FDA Adverse Event Reporting System (FAERS) database. [PDF]
PLoS ONEBackgroundPenicillamine(D-Penicillamine) and trientine are first-line therapies for Wilson's Disease (WD), yet real-world data on their adverse events (AEs) remain scarce.
Wenlong Qian +12 more
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Crystal structure of S,N-dibenzyl-d-penicillamine monohydrate [PDF]
Acta Crystallographica Section E, 2014 In the asymmetric unit of the title compound, C19H23NO2S·H2O, there are two independent organic molecules and two water molecules. Both organic molecules exist as the zwitterionic form.
Nobuto Yoshinari, Takumi Konno
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Comparative review of copper-associated chronic hepatitis in dogs and Wilson disease in humans [PDF]
Frontiers in Veterinary ScienceCopper-associated chronic hepatitis (CAH) in dogs and Wilson disease (WD) in humans are progressive hepatic disorders caused by copper accumulation. Although both diseases share similar pathomechanisms of copper-induced liver injury, they diverge in some
Tarini Ullal +3 more
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Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators [PDF]
BMC Cancer, 2006 Background Upregulation of endogenous angiostatin levels may constitute a novel anti-angiogenic, and therefore anti-tumor therapy. In vitro, angiostatin generation is a two-step process, starting with the conversion of plasminogen to plasmin by ...
Maass Cathy N +5 more
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Annals of Indian Academy of Neurology, 2022 Background: Most centers in developing countries prefer chelation therapy with D-penicillamine for the management of Wilson's disease (WD) because of its easy availability and affordability. Neurological worsening following treatment with D-penicillamine
Madhan Kumar +5 more
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Penicillamine Nephropathy [PDF]
Nephron, 1980 8 patients who developed proteinuria whilst receiving penicillamine for rheumatoid arthritis have been studied. Light microscopy of renal biopsy specimens showed evidence of an extramembranous nephropathy in 6 cases, with epimembranous spikes infrequently described previously in association with penicillamine.
J H, Ross, F, McGinty, D G, Brewer
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Psychosis in Wilson's disease: A rare case presentation
Archives of Mental Health, 2021 Wilson's disease is an uncommon genetic disorder, in which abnormal copper accumulation occurs in various parts of the body. Approximately 30% of patients debut with neuropsychiatric symptoms posing a diagnostic challenge in the initial phase.
Kota Raga Sumedha +2 more
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Controlled administration of penicillamine reduces radiation exposure in critical organs during 64Cu-ATSM internal radiotherapy: a novel strategy for liver protection. [PDF]
PLoS ONE, 2014 PURPOSE: (64)Cu-diacetyl-bis (N (4)-methylthiosemicarbazone) ((64)Cu-ATSM) is a promising theranostic agent that targets hypoxic regions in tumors related to malignant characteristics.
Yukie Yoshii +10 more
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