Results 41 to 50 of about 16,893 (203)

The in vitro loss of penicillamine in plasma, albumin solutions, and whole blood: Implications for pharmacokinetic studies of penicillamine [PDF]

, 1980
The recent development of a high performance liquid chromatography assay method for the analysis of penicillamine in biological samples such as plasma, whole blood, and urine has provided a specific and sensitive assay method to aid in the study of ...
Bergstrom, Richard F., Kay, Donald R., Wagner, John G.   +2 more
core   +1 more source

Brass Metal Cookware Associated Lead Poisoning Presenting as Recurrent Abdominal Pain: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Lead is known to exert toxic effects on nearly all tissues and organ systems, with the nervous, gastrointestinal, and haematopoietic systems being particularly vulnerable. In humans, lead interferes with haemoglobin synthesis, leading to anaemia, and its
Karthik Basumani, Vilasini Basumani, Thandalam Kothandaraman Anand, Sathishkumar Elumalai, Pandurangan Basumani   +4 more
doaj   +1 more source

Determination of penicillamine, tiopronin and glutathione in pharmaceutical formulations by kinetic spectrophotometry

Acta Pharmaceutica, 2021
A novel and simple method for the determination of penicillamine (PEN), tiopronin (mercaptopropionyl glycine, MPG) and glutathione (GSH) in pharmaceutical formulations by kinetic spectrophotometry has been developed and validated.
Kukoc-Modun Lea, Biocic Maja, Radić Njegomir   +2 more
doaj   +1 more source

Extending Peptide Ligation to Acidic pH and Junctions Comprising Glycosylated and Phosphorylated Amino Acids

Angewandte Chemie International Edition, EarlyView.
A pyridine‐containing ligation auxiliary eliminates a major bottleneck of peptide ligation chemistry. The extended range of applicable pH values (2.0–7.5) in the ligation reaction helps to avoid epimerization. Native chemical ligation (NCL) proceeds at virtually any junction, including reactions at β‐branched amino acids, as well as O‐glycosylated or O‐
Sebastian Trunschke, Antonia Feida, Hendrik Hanebrink, Arseniy Galashov, Alina Herfort, Oliver Seitz   +5 more
wiley   +1 more source

Modular Access to α‐Tertiary Amines: Electrochemical Tandem Di‐Functionalization of Olefins With Ammonia Surrogates and Amino Acids

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A metal‐ and oxidant‐free electrochemical multicomponent di‐functionalization strategy that rapidly converts 1,1‐disubstituted alkenes into α‐tertiary primary amines with simultaneous installation of bio‐relevant sulfur or selenium motifs was devised for late‐stage functionalization. ABSTRACT Quaternary carbon centers, especially those bearing nitrogen,
Adrija Ghosh, Tarun, Sven Erik Peters, Lutz Ackermann, Debasis Banerjee   +4 more
wiley   +2 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

DFT-QTAIM Study of Gold Nanoparticles and Cyclic Peptide as Effective Drug Nanocarriers

Orbital: The Electronic Journal of Chemistry, 2020
In this study, cyclic peptide (CP) with cyclooctaglycine model and gold nanoparticles (AuNP) with Au6 cluster model were used to examin the function of penicillamine (PCA) drug on ten different configurations of cyclic peptide-gold nanoparticles (CPAuNP).
Bahareh Khoshbayan, Ali Morsali, Safar Ali Beyramabadi, Mohammad Reza Bozorgmehr   +3 more
doaj   +3 more sources

Dual‐targeted nanomedicine delivering doxorubicin and nitric oxide for tumor immunomodulation and synergistic therapy

BMEMat, EarlyView.
The mechanism of HA‐DS@PLGA nanoparticles co‐delivering DOX and SNAP (an NO donor) to suppress tumor growth, remodel the tumor microenvironment, and enhance antitumor immune responses for effective combinatorial cancer therapy. Abstract Cancer therapeutic efficacy is significantly influenced by tumor immunosuppressive environment possibly induced by ...
Xingzhou Peng, Wei Chen, Shuyu Li, Xiaomin Ma, Yanfeng Dai, Yan Wang, Changqiang Xie, Yazhe Xiao, Hesong Han, Yumiao Zhang, Junjie Wang   +10 more
wiley   +1 more source

D-Penicillamine-Induced Polymyositis Occurring in Patients with Rheumatoid Arthritis: A Report of Two Cases and Demonstration of a Positive Lymphocyte Stimulation Test to D-Penicillamine [PDF]

, 1986
Two patients with erosive, seropositive rheumatoid arthritis developed polymyositis during treatment with D-penicillamine. In both patients the HLA tissue typing revealed the presence of DR4.
Kono, Ichiro, Kashiwagi, Heihachiro, Kabashima, Teizo, Matsumura, Takayuki, Yamane, Kazuhide, Yuhara, Takamichi   +5 more
core   +1 more source

Genetic Etiologies of Dystonia with Anarthria/Aphonia

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dystonia with anarthria and/or aphonia (DAnAp) represents a distinctive phenotype manifesting across lifespan. Frequently associated with genetic disorders, early recognition is critical for diagnosis and management. Objectives To provide practical recommendations for the clinical evaluation of patients with DAnAp, enhancing ...
Anika Ménétrey, Eriberto Rayco, Maziar Emamikhah Abarghouei, Susan H. Fox, Anthony E. Lang, George M. Ibrahim, Carolina Gorodetsky, Christos Ganos   +7 more
wiley   +1 more source