Results 51 to 60 of about 15,104 (214)

Hyperactivation and Tyrosine Phosphorylation of Cryopreserved Stallion Spermatozoa in Relation to Conventional In Vitro Fertilization Blastocyst Production

open access: yesAndrology, EarlyView.
ABSTRACT Background Challenges in establishing clinical conventional in vitro fertilization (IVF) in horses include variation in sperm and oocyte quality, which can be affected by mare age. Extended preincubation of stallion spermatozoa has resulted in successful IVF.
Raul A. Gonzalez‐Castro   +6 more
wiley   +1 more source

In Vitro Sperm–Epididymosomes Interaction Immediately Before Fertilization Changes Sperm Fertility Potential

open access: yesAndrology, EarlyView.
ABSTRACT Background Sperm acquire fertility ability during epididymal maturation mainly in the epididymal caput and corpus, and once matured, are stored in the epididymal cauda. During storage, interactions with cauda epididymosomes (epEVs) may influence sperm fertility potential; however, the role of such interactions on sperm fertility remains ...
Maíra Bianchi Rodrigues Alves   +7 more
wiley   +1 more source

Synthesis and Characterization of Gold Chiral Nanoparticles Functionalized by a Chiral Drug

open access: yesNanomaterials, 2023
Inorganic chiral nanoparticles are attracting more and more attention due to their peculiar optical properties and potential biological applications, such as bioimaging, therapeutics, and diagnostics.
Simona Bettini   +8 more
doaj   +1 more source

Relative Exchangeable Copper Confirms Wilson Disease and Supports Reclassification of the ATP7B p.Met665Ile Variant With Conflicting Pathogenicity Evidence

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1691-1695, July 2026.
ABSTRACT Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B mutations. Diagnosis is usually straightforward in symptomatic patients, but can be challenging in children and adolescents with mild liver disease, borderline urinary copper excretion, or inconclusive genetic findings.
Emanuele Nicastro   +10 more
wiley   +1 more source

Mechanistic, energetic and structural studies of single-walled carbon nanotubes functionalized with penicillamine [PDF]

open access: yesJournal of the Serbian Chemical Society, 2018
Using the density functional theory, the possible non-covalent interactions and six mechanisms of covalent functionalization of the drug penicillamine with functionalized carbon nanotubes (CNT) were investigated.
Shaki Hosein   +4 more
doaj   +1 more source

Safety, Tolerability, and Pharmacokinetics of GMDTC for Cadmium Poisoning: A Randomized Phase 1a/1b Trial

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 160-167, July 2026.
Cadmium exposure causes serious health consequences; however, there is no clinically approved antidote for cadmium poisoning. This Phase 1a/1b trial aimed to investigate safety, tolerability, and pharmacokinetics of Sodium (S)‐2‐(dithiocarboxylato((2S,3R,4R,5R)‐2,3,4,5,6‐pentahydroxyhexyl) amino)‐4‐(methylthio) butanoate (GMDTC), a novel chelating ...
Xuefeng Ren   +21 more
wiley   +1 more source

Comparative review of copper-associated chronic hepatitis in dogs and Wilson disease in humans

open access: yesFrontiers in Veterinary Science
Copper-associated chronic hepatitis (CAH) in dogs and Wilson disease (WD) in humans are progressive hepatic disorders caused by copper accumulation. Although both diseases share similar pathomechanisms of copper-induced liver injury, they diverge in some
Tarini Ullal   +3 more
doaj   +1 more source

Comparison of the Effectiveness and Safety of d-Penicillamine and Zinc Salt Treatment for Symptomatic Wilson Disease: A Systematic Review and Meta‐Analysis

open access: yesFrontiers in Pharmacology, 2022
Background: Pharmacological therapy is currently the main treatment method for patients with Wilson disease (WD). We aimed to evaluate the efficacy and safety of the common treatment regimens in these patients.Methods: We conducted a systemic review and ...
Shan Tang   +10 more
doaj   +1 more source

Engineered Metal–Organic Frameworks‐Based Materials for Environmental Detection

open access: yesENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 4, July 2026.
Engineered metal–organic frameworks (MOFs) regulated by various material modification strategies are discussed for environmental contaminant detection under different sensing mechanisms, providing future improvements of MOFs in environmental detection. Sensitive and selective detection of contaminants is crucial for environmental protection.
Pan Gao   +3 more
wiley   +1 more source

Brass Metal Cookware Associated Lead Poisoning Presenting as Recurrent Abdominal Pain: A Case Report [PDF]

open access: yesJournal of Clinical and Diagnostic Research
Lead is known to exert toxic effects on nearly all tissues and organ systems, with the nervous, gastrointestinal, and haematopoietic systems being particularly vulnerable. In humans, lead interferes with haemoglobin synthesis, leading to anaemia, and its
Karthik Basumani   +4 more
doaj   +1 more source

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