D-penicillamine induced degenerative dermopathy
Indian Journal of Dermatology, 2015 D-penicillamine interferes with elastin and collagen metabolism and produces several cutaneous and multi-systemic side-effects. We present two cases of Wilson′s disease who on long-term penicillamine therapy developed drug-induced degenerative dermopathy
Sujay Khandpur +4 more
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Management of children and adolescents with Wilson Disease and neurological worsening following D–Penicillamine therapy: A single centre experience [PDF]
Annals of Indian Academy of Neurology, 2022 Background: Most centers in developing countries prefer chelation therapy with D-penicillamine for the management of Wilson's disease (WD) because of its easy availability and affordability. Neurological worsening following treatment with D-penicillamine
Madhan Kumar +5 more
doaj +2 more sources
D-Penicillamine: The State of the Art in Humans and in Dogs from a Pharmacological and Regulatory Perspective [PDF]
Antibiotics, 2021 Chelant agents are the mainstay of treatment in copper-associated hepatitis in humans, where D-penicillamine is the chelant agent of first choice. In veterinary medicine, the use of D-penicillamine has increased with the recent recognition of copper ...
Michela Pugliese +6 more
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Comparison of the Effectiveness and Safety of d-Penicillamine and Zinc Salt Treatment for Symptomatic Wilson Disease: A Systematic Review and Meta‐Analysis [PDF]
Frontiers in Pharmacology, 2022 Background: Pharmacological therapy is currently the main treatment method for patients with Wilson disease (WD). We aimed to evaluate the efficacy and safety of the common treatment regimens in these patients.Methods: We conducted a systemic review and ...
Shan Tang +10 more
doaj +2 more sources
D-penicillamine Induced Myasthenia Gravis in Wilson’s Disease: A Case Report [PDF]
Journal of Nepal Medical Association, 2022 Myasthenia gravis is a neuromuscular junction disorder characterised by fluctuating muscle weakness, improved by using anti-cholinesterase drugs. In addition to the autoimmune aetiology, various factors such as infections, surgery, and drugs are known ...
Lekhjung Thapa +7 more
doaj +2 more sources
Outcomes of Tiopronin and D-Penicillamine Therapy in Pediatric Cystinuria: A Clinical Comparison of Two Cases [PDF]
ReportsBackground and Clinical Significance: Cystinuria is the most common genetic cause of pediatric nephrolithiasis, characterized by impaired renal cystine reabsorption and resulting in increased urinary cystine excretion.
Brooke Schaefer +2 more
doaj +2 more sources
Post-marketing safety signals of Wilson’s disease therapies: evidence from FAERS and VigiBase [PDF]
Orphanet Journal of Rare DiseasesIntroduction Wilson’s disease is a rare autosomal copper metabolism recessive disorder that requires lifelong pharmacological treatment. D-penicillamine and trientine are the most commonly used copper chelators.
Hülya Tezel-Yalçın +3 more
doaj +2 more sources
Benefits and drawbacks of current copper chelators in Wilson disease [PDF]
Romanian Journal of Neurology, 2023 Background. Wilson disease (WD) is an autosomal-recessive disorder of copper metabolism, caused by mutations in the ATP7B gene, which codes for a membrane-bound copper-binding ATPase.
Ioan-Cristian Lupescu +6 more
doaj +1 more source
EFFECT OF COPPER SULPHATE POLLUTION AND ITS ANTIDOTE PENICILLAMINE ON SERUM AND BRAIN TISSUES MARKERS OF ALBINO RATS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2022 Background: Copper is an essential trace element and is required for many metabolic functions. Aim of work: The present study was designed to study the negative impact of excess copper sulphate on the central neural function of albino rats and studying ...
Doaa Abdel-Fattah +4 more
doaj +1 more source
The Effects of Succimer and Penicillamine on Acute Lead Poisoning Patients
International Journal of Medical Toxicology and Forensic Medicine, 2021 Background: Lead poisoning was on the rise in recent years. There exists a lack of easy access to some of the main chelator drugs in developing countries.
Gholamali +4 more
doaj +1 more source