Results 21 to 30 of about 11,635 (130)

A Highly Sensitive Dual-Signal Strategy via Inner Filter Effect between Tween 20-Gold Nanoparticles and CdSe/ZnS Quantum Dots for Detecting Cu²⁺

Micromachines, 2023
A highly sensitive and accurate dual-signal strategy is developed for trace Cu2+ detection based on the inner filter effect (IFE) between Tween 20-gold nanoparticles (AuNPs) and CdSe/ZnS quantum dots (QDs).
Yong Xie, Chao Bian, Mingjie Han, Ri Wang, Yang Li, Yuhao Xu, Shanhong Xia   +6 more
doaj   +1 more source

Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators

BMC Cancer, 2006
Background Upregulation of endogenous angiostatin levels may constitute a novel anti-angiogenic, and therefore anti-tumor therapy. In vitro, angiostatin generation is a two-step process, starting with the conversion of plasminogen to plasmin by ...
Maass Cathy N, Lamers-Elemans Iris L, Ruers Theo JM, de Groot-Besseling Renate RJ, de Waal Robert MW, Westphal Johan R   +5 more
doaj   +1 more source

Analyzing the Therapeutic Efficacy of Bis-Choline-Tetrathiomolybdate in the Atp7b^−/− Copper Overload Mouse Model

Biomedicines, 2021
Bis-choline-tetrathiomolybdate, introduced as WTX101 (now known as ALXN1840), is a first-in-class copper-protein-binding agent for oral therapy of Wilson’s disease.
Philipp Kim, Chengcheng Christine Zhang, Sven Thoröe-Boveleth, Eva Miriam Buhl, Sabine Weiskirchen, Wolfgang Stremmel, Uta Merle, Ralf Weiskirchen   +7 more
doaj   +1 more source

The Specific Copper(II) Chelator TDMQ20 Is Efficient for the Treatment of Wilson’s Disease in Mice

Pharmaceutics, 2023
(1) Background: In patients with Wilson’s disease, the deficiency of the copper carrier ATP7B causes the accumulation of copper in the liver, brain and various other organs.
Yingshan Zhu, Ying Tang, Lan Huang, Michel Nguyen, Yan Liu, Anne Robert, Bernard Meunier   +6 more
doaj   +1 more source

Nephrotic syndrome after treatment with D-penicillamine in a patient with Wilson’s disease

Romanian Journal of Laboratory Medicine, 2014
Wilson’s disease is an inherited autosomal recessive disorder of copper balance leading to accumulation of copper mainly in liver and brain result from absent or reduced function of copper-transporting P-type ATPase.
Kostadinova Anna D., Mihaylov Marian Y., Ivanova Irena D., Robeva Rayna T.   +3 more
doaj   +1 more source

Metabolic balances of sulfur in patients with hepatolenticular degeneration and effect of the use of D-penicillamine

Arquivos de Neuro-Psiquiatria, 1969
The metabolic balances of sulfur in two cases of hepatolenticular degeneration were studied. A positive balance was found in both cases; in one patient submitted to mixed diet, the average was significantly higher than the normal mean. The administration
Horacio M. Canelas, Francisco B. De Jorge, Waldir A. Tognola   +2 more
doaj   +1 more source

Synthesis and Characterization of Gold Chiral Nanoparticles Functionalized by a Chiral Drug

Nanomaterials, 2023
Inorganic chiral nanoparticles are attracting more and more attention due to their peculiar optical properties and potential biological applications, such as bioimaging, therapeutics, and diagnostics.
Simona Bettini, Michela Ottolini, Donato Valli, Rosanna Pagano, Chiara Ingrosso, Maarten Roeffaers, Johan Hofkens, Ludovico Valli, Gabriele Giancane   +8 more
doaj   +1 more source

Validity of D-penicillamine in experimental cerebral vasospasm therapy

Interdisciplinary Neurosurgery
Background: Cerebral vasospasm is a reversible vessel constriction following subarachnoid hemorrhage. Immunoreactive and inflammatory mechanisms induce long-term vasoconstriction and vessel dilatation inhibition.
Ersin Haciyakupoglu, Evren Yüvrük, Sebahattin Haciyakupoglu, Milos Arsenovic, Erol Akgül, Dervis Mansuri Yilmaz, Sait Polat   +6 more
doaj   +1 more source

Modular Access to α‐Tertiary Amines: Electrochemical Tandem Di‐Functionalization of Olefins With Ammonia Surrogates and Amino Acids

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A metal‐ and oxidant‐free electrochemical multicomponent di‐functionalization strategy that rapidly converts 1,1‐disubstituted alkenes into α‐tertiary primary amines with simultaneous installation of bio‐relevant sulfur or selenium motifs was devised for late‐stage functionalization. ABSTRACT Quaternary carbon centers, especially those bearing nitrogen,
Adrija Ghosh, Tarun, Sven Erik Peters, Lutz Ackermann, Debasis Banerjee   +4 more
wiley   +2 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source