Results 31 to 40 of about 11,635 (130)

Dual‐targeted nanomedicine delivering doxorubicin and nitric oxide for tumor immunomodulation and synergistic therapy

BMEMat, EarlyView.
The mechanism of HA‐DS@PLGA nanoparticles co‐delivering DOX and SNAP (an NO donor) to suppress tumor growth, remodel the tumor microenvironment, and enhance antitumor immune responses for effective combinatorial cancer therapy. Abstract Cancer therapeutic efficacy is significantly influenced by tumor immunosuppressive environment possibly induced by ...
Xingzhou Peng, Wei Chen, Shuyu Li, Xiaomin Ma, Yanfeng Dai, Yan Wang, Changqiang Xie, Yazhe Xiao, Hesong Han, Yumiao Zhang, Junjie Wang   +10 more
wiley   +1 more source

Synthesis and chelating properties of substituted formyl pyridine thiosemicarbazones of potential biological activity [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1999
The synthesis of a series of 4-​(un)​substituted thiosemicarbazones of 6-​methyl-​5-​nitropyridine-​2-​carboxaldehyde, I (R = H, n-​Bu, 4-​ClC6H4, etc.)​, is reported by two different routes.  The prepd. compds.
Hoda Hassan
doaj   +1 more source

Genetic Etiologies of Dystonia with Anarthria/Aphonia

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dystonia with anarthria and/or aphonia (DAnAp) represents a distinctive phenotype manifesting across lifespan. Frequently associated with genetic disorders, early recognition is critical for diagnosis and management. Objectives To provide practical recommendations for the clinical evaluation of patients with DAnAp, enhancing ...
Anika Ménétrey, Eriberto Rayco, Maziar Emamikhah Abarghouei, Susan H. Fox, Anthony E. Lang, George M. Ibrahim, Carolina Gorodetsky, Christos Ganos   +7 more
wiley   +1 more source

Prevalence and Associations of Abnormal Levels of Vitamin B6 in People with Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background In people with Parkinson's disease, abnormal levels of vitamin B6 may be associated with polyneuropathy and epileptic seizures, including medication‐refractory status epilepticus. Objectives To estimate the prevalence and explore associations of abnormal levels of vitamin B6 in people with Parkinson's disease.
Karlo J. Lizarraga, Lu Wang, Hannah Mesmer, Nami Shah, William Barbosa, Eric Logigian, Michael P. McDermott, Anthony E. Lang   +7 more
wiley   +1 more source

Hydrogen‐bond‐mediated retention of a phenolic SNAP analogue in polyvinyl alcohol/PEG hydrogels for sustained nitric oxide release and antibacterial activity

Smart Molecules, EarlyView.
A hydrogen‐bond‐donating NO donor was designed to interact specifically with the hydrogel network, thereby minimizing donor leakage and achieving prolonged NO release. Abstract Nitric oxide (NO)‐releasing materials have attracted considerable interest for their potential in diverse biomedical applications.
Yixin Zhu, Peixuan Wu, Shuting Zhang, Congjun Xu, Guanghua Xia, Jiangli Fan, Nicola E. Brasch, Yang Zhou, Yuanyuan Liu   +8 more
wiley   +1 more source

Synthesis and anti-intracellular Copper overload evaluation of Nanoconjugated D-penicillamine –Dendrimer in Wilson’s model cells

مجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Wilson’s disease (WD) is caused by mutation to the cooer-transporting gene ATP7B. Chelation therapy is the main protochol of treatment for patients with Wilson’s disease.
Fani N, Shafiee Ardestani M, Yaghmaei P, Assadi A, Barzegar Behrouz A   +4 more
doaj  

Response to different therapeutic approaches in Wilson disease. A long-term follow up study

Annals of Hepatology, 2012
Background and aims. There are certain areas of uncertainty regarding the best therapeutic approach in patients diagnosed with Wilson Disease (WD). Our aim was to assess treatment response to different therapies in a cohort of WD patients followed in a ...
Beatriz Rodríguez, Juan Burguera, Marina Berenguer, M.D.   +2 more
doaj   +1 more source

Hyperactivation and Tyrosine Phosphorylation of Cryopreserved Stallion Spermatozoa in Relation to Conventional In Vitro Fertilization Blastocyst Production

Andrology, EarlyView.
ABSTRACT Background Challenges in establishing clinical conventional in vitro fertilization (IVF) in horses include variation in sperm and oocyte quality, which can be affected by mare age. Extended preincubation of stallion spermatozoa has resulted in successful IVF.
Raul A. Gonzalez‐Castro, Carolina C. Porflidt, Alexandra L. Ash, Jacobo S. Rodriguez, Perla D. Fleury, Edward L. Squires, Elaine M. Carnevale   +6 more
wiley   +1 more source

Nutrient‐specific combinatorial secretion of GLP‐1 and neurotransmitters in the enteroendocrine L‐cell line GLUTag

The FEBS Journal, EarlyView.
Enteroendocrine L cells function as chemosensors in the intestine. Using the L‐cell line GLUTag, we show that distinct nutrients trigger different combinations of co‐secretion of GLP‐1 and neurotransmitters: D‐glucose evokes GLP‐1, glutamate, and ATP; L‐glutamine evokes GLP‐1 and glutamate; sucralose and butyrate evoke only GLP‐1.
Yo Ito, Kazuki Harada, Yuri Osuga‐Yoshiike, Masami Yokota Hirai, Tetsuya Kitaguchi, Takashi Tsuboi   +5 more
wiley   +1 more source

Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless, Riccardo Milazzo, Martin S. Bojer, Benjamin S. Sereika‐Bejder, Hanne Ingmer, Christian A. Olsen   +5 more
wiley   +2 more sources