Results 51 to 60 of about 10,278,879 (215)

Safety, Tolerability, and Pharmacokinetics of GMDTC for Cadmium Poisoning: A Randomized Phase 1a/1b Trial

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 160-167, July 2026.
Cadmium exposure causes serious health consequences; however, there is no clinically approved antidote for cadmium poisoning. This Phase 1a/1b trial aimed to investigate safety, tolerability, and pharmacokinetics of Sodium (S)‐2‐(dithiocarboxylato((2S,3R,4R,5R)‐2,3,4,5,6‐pentahydroxyhexyl) amino)‐4‐(methylthio) butanoate (GMDTC), a novel chelating ...
Xuefeng Ren   +21 more
wiley   +1 more source

D-penicillamine in the treatment of eosinophilic fasciitis: case reports and review of the literature.

open access: yes, 2012
Eosinophilic fasciitis (EF) is a rare disease characterized by symmetrical thickness and hardening of the skin, especially localized to forearms and thorax, with eosinophilia.
A. M. Cesinaro   +6 more
core   +1 more source

Engineered Metal–Organic Frameworks‐Based Materials for Environmental Detection

open access: yesENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 4, July 2026.
Engineered metal–organic frameworks (MOFs) regulated by various material modification strategies are discussed for environmental contaminant detection under different sensing mechanisms, providing future improvements of MOFs in environmental detection. Sensitive and selective detection of contaminants is crucial for environmental protection.
Pan Gao   +3 more
wiley   +1 more source

Self‐Immolative Gels: Programmable Degradation Using Self‐Immolative Linkers and Polymers

open access: yesChemistry – A European Journal, Volume 32, Issue 23, 16 June 2026.
Self‐immolative linkers and polymers undergo bond‐cleaving reaction cascades in response to specific stimuli. Their incorporation into gels can be harnessed to release cargo, induce property changes, or trigger degradation in a highly controlled manner. These functions can be employed in applications such as sensing and drug delivery.
Chuanfeng Li, Elizabeth R. Gillies
wiley   +1 more source

An Outline of D-penicillamine Metabolism [PDF]

open access: yesProceedings of the Royal Society of Medicine, 1977
In a study using 14C-D-penicillamine in a normal subject only 50% of the D-penicillamine was absorbed from the gut. The major urinary metabolites are cysteine-penicillamine and penicillamine disulphide. S-methyl-D-penicillamine is the only biochemically transformed metabolite so far identified.
openaire   +2 more sources

Vat Polymerization 3D Printing for Controlled Drug Release Applications

open access: yesAdvanced Materials Technologies, Volume 11, Issue 11, 5 June 2026.
ABSTRACT Vat polymerization (VP) 3D printing, a light‐based additive manufacturing technique, has emerged as a promising technique for fabricating complex drug delivery systems with high precision and spatial resolution. This layer‐by‐layer manufacturing process enables the creation of intricate geometries and customizable architectures, which are ...
Hafiz Busari   +2 more
wiley   +1 more source

Effect of D-penicillamine in prevention of post operative pelvic adhesion formation in rat

open access: yesJournal of Research in Medical Sciences, 2006
INTRODUCTION: Adhesion formation after pelvic surgery is still a major cause of several morbidities such as infertility, pain, bowel obstruction and subsequent intra-operative complications.
Ata-Allah Ghahiri   +3 more
doaj  

Elastosis Perforans Serpiginosa: a D-penicillamine induced dermatoses in a patient with Wilson’s disease

open access: yesAutopsy and Case Reports, 2021
Long term use of D-penicillamine for Wilson’s disease can be associated with many adverse reactions and systemic side effects. We report the case of a 28-year-old male patient diagnosed with Wilson’s disease presenting with a serpiginous raised ...
Swagatika Samal, Mukund Sable
doaj  

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

open access: yesAdvanced Science, Volume 13, Issue 32, 9 June 2026.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou   +10 more
wiley   +1 more source

Is D-penicillamine Safe in Management of Little Children with Kidney Cystine Stones? A Case Series

open access: yes, 2015
Nephrolithiasis is quite common in children. It sometimes has a genetic basis and can lead to serious complications like urinary obstruction, multiple surgical interventions, or even renal insufficiency if left treated.
Arshadi, Hamid   +6 more
core   +1 more source

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