Results 31 to 40 of about 22,986 (208)
Antibiotics, 2021 Chelant agents are the mainstay of treatment in copper-associated hepatitis in humans, where D-penicillamine is the chelant agent of first choice. In veterinary medicine, the use of D-penicillamine has increased with the recent recognition of copper ...
Michela Pugliese +6 more
doaj +1 more source
Benefits and drawbacks of current copper chelators in Wilson disease [PDF]
Romanian Journal of Neurology, 2023 Background. Wilson disease (WD) is an autosomal-recessive disorder of copper metabolism, caused by mutations in the ATP7B gene, which codes for a membrane-bound copper-binding ATPase.
Ioan-Cristian Lupescu +6 more
doaj +1 more source
Rhabdomyolysis and muscle necrosis induced by lead poisoning
Advanced Biomedical Research, 2020 A case is presented on a 40-year-old male with chronic lead poisoning with loss of consciousness, rhabdomyolysis, and acute renal failure after occupational exposure.
Behnaz Ansari +4 more
doaj +1 more source
Effect of lead intoxication and D-penicillamine treatment on hematological indices in rats [PDF]
, 2007 Lead is one of the most important environmental pollution which is toxic to many organ systems. D-penicillamine (D-P) is a chelator drug which is used for treatment of lead toxicity for several years.
Ghafari, S. +5 more
core +1 more source
Frontiers in Chemistry, 2020 Peptide toxins that adopt the inhibitory cystine knot (ICK) scaffold have very stable three-dimensional structures as a result of the conformational constraints imposed by the configuration of the three disulfide bonds that are the hallmark of this fold.
Stephen McCarthy +4 more
doaj +1 more source
Quantitative assessment of angiogenesis in murine antigen-induced arthritis by intravital fluorescence microscopy [PDF]
, 2003 Inhibition of angiogenesis might be a therapeutic approach to prevent joint destruction caused by the overgrowing synovial tissue during chronic joint inflammation.
Krombach, F. +7 more
core +1 more source
Acetaldehyde involvement in ethanol's postabsortive effects during early ontogeny [PDF]
, 2013 Clinical and biomedical studies sustains the notion that early ontogeny is a vulnerable window to the impact of alcohol. Experiences with the drug during these stages increase latter disposition to prefer, use or abuse ethanol.
Abate, Paula +2 more
core +1 more source
D-penicillamine induced degenerative dermopathy
Indian Journal of Dermatology, 2015 D-penicillamine interferes with elastin and collagen metabolism and produces several cutaneous and multi-systemic side-effects. We present two cases of Wilson′s disease who on long-term penicillamine therapy developed drug-induced degenerative dermopathy
Sujay Khandpur +4 more
doaj +1 more source
Acta Pharmaceutica, 2021 A novel and simple method for the determination of penicillamine (PEN), tiopronin (mercaptopropionyl glycine, MPG) and glutathione (GSH) in pharmaceutical formulations by kinetic spectrophotometry has been developed and validated.
Kukoc-Modun Lea +2 more
doaj +1 more source
An Attempted Suicide with Copper Sulphate injected intravenously:Pathopsysiology and Therapy about a case report [PDF]
, 2017 Acute copper sulphate poisoning is an unusual event, rarely following parenteral exposure, complicated by toxicological effects as haemolytic anaemia, methaemoglobinaemia , hepato-renal damage and acute rhabdomyolysis.
Baldini, Enrico +6 more
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