Results 11 to 20 of about 16,628 (221)
Effects of antirheumatic agents on cytokines [PDF]
Seminars in Arthritis and Rheumatism, 1996 A review of the literature concerning the effects of traditional antirheumatic drugs on cytokines and the cytokine and anticytokine approaches already used in the therapy of rheumatoid arthritis (RA) is presented. Many antirheumatic drugs are capable of cytokine modulation in vitro. Corticosteroids inhibit the transcription of a broad spectrum of genes
Pilar Barrera +3 more
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Effect of Benzylidene Derivative (Novel Antirheumatic Agent) on Chondrocyte Metabolism.
Journal of Pharmacobio-Dynamics, 1992 The effects of protocatechualdehyde (PAL), one of the metabolites of 3,4-diacetoxy benzylidene diacetate (ACP), on proteoglycan metabolism and secretion of interleukin 1 (IL-1) like activity (lymphocyte activating factor; LAF activity) were studied using rabbit articular chondrocytes culture under phorbol myristate acetate (PMA) and Ca2+ ionophore ...
Koju Watanabe +2 more
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4. Antirheumatic Agents for Treatment of Rheumatoid Arthritis
Nihon Naika Gakkai Zasshi, 2008 Hisashi Yamanaka
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Studies on antirheumatic agents. 3-Benzoylpropionic acid derivatives.
Chemical and Pharmaceutical Bulletin, 1988 AbstractThe acetophenones (I) and glyoxylic acid (II) are combined to give the α,β‐unsaturated acids (III) which react with thioacetic acid (IV), producing the adducts (V).
Kazuya Kameo +5 more
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Antirheumatic Agents. I. Novel Methotrexate Derivatives Bearing an Indoline Moiety.
Chemical and Pharmaceutical Bulletin, 1996 Various novel methotrexate (MTX) derivatives bearing an indoline moiety were synthesized and tested for biological activities using human peripheral blood mononuclear cell (hPBMC) and human synovial cells (hSC) derived from patients with rheumatoid arthritis (RA).
Hiroharu Matsuoka +7 more
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Antirheumatic agents in covid-19: is IL-6 the right target? [PDF]
Annals of the Rheumatic Diseases, 2020 The letter of Monti et al 1 on covid-19 in patients with chronic arthritis treated with immunosuppressive therapies stimulates some considerations. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects cells through the ACE-2 receptor, which is highly expressed in both the lung and the heart. Besides direct tissue injury, SARS-CoV-2
Pier Leopoldo Capecchi +12 more
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Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity [PDF]
The Korean Journal of Internal Medicine, 2020 Background/Aims The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA ...
Kichul Shin +23 more
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Frontiers in Medicine, 2022 BackgroundCOVID-19 may present different degrees of severity. Viral infections in patients with rheumatic inflammatory diseases (R-IMID) trend to present more severe disease.
David Martínez-López +10 more
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BMC Rheumatology, 2020 Background Our study aimed to compare efficacy and safety of Hetero’s adalimumab (Mabura®, Hetero Biopharma Limited) versus reference adalimumab (Humira®, Abbvie Inc.) in Indian patients with active rheumatoid arthritis (RA) concomitant on methotrexate ...
Shubhadeep Sinha +19 more
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Baseline use of hydroxychloroquine or immunosuppressive drugs and the risk of coronavirus disease 2019 [PDF]
The Korean Journal of Internal Medicine, 2022 Background/Aims The preventive role of hydroxychloroquine (HCQ) on coronavirus disease 2019 (COVID-19) remains unclear. The aim of this study was to examine the effects of HCQ and other immunosuppressive drugs on the incidence of COVID-19.
Ji-Won Kim +5 more
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