Results 191 to 200 of about 16,628 (221)
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Drug therapy reviews: Antirheumatic agents
American Journal of Health-System Pharmacy, 1979The pathophysiology, symptoms and drug treatment of rheumatic disease are reviewed. Antirheumatic drugs reviewed are salicylates (including aspirin, sodium salicylate, choline salicylate, choline magnesium salicylate, salsalate), phenylpropionic acid derivatives (fenoprofen, ibuprofen, naproxen), indole derivatives (sulindac, tolmetin and indomethacin),
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Drugs, 2002
Several new drugs have become available for the treatment of patients with osteoarthritis and rheumatoid arthritis (RA). These agents include selective cyclooxygenase (COX)-2 inhibitors, leflunomide and anti-tumour necrosis factor (TNF)-alpha antagonists.
Nurmohamed, Michael T +2 more
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Several new drugs have become available for the treatment of patients with osteoarthritis and rheumatoid arthritis (RA). These agents include selective cyclooxygenase (COX)-2 inhibitors, leflunomide and anti-tumour necrosis factor (TNF)-alpha antagonists.
Nurmohamed, Michael T +2 more
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Antirheumatic agents and leukocyte recruitment
Biochemical Pharmacology, 1999Most anti-inflammatory agents used in the treatment of joint diseases exert inhibitory effects on leukocyte infiltration. Methotrexate, a disease-modifying drug, and corticosteroids also inhibit leukocyte accumulation during inflammation. However, the mechanisms of action of these different compounds on leukocytes vary and in the case of non-steroidal ...
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Evaluation of Ibuprofen (Motrin)
JAMA, 1975Ibuprofen is a new, mild analgesic agent that may be useful in the symptomatic treatment of rheumatoid arthritis and osteoarthritis. Results of clinical studies have shown that its beneficial effects in these conditions are comparable, but not superior, to those of aspirin. However, at recommended doses it has less anti-inflammatory effect than aspirin.
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Effect of a Benzylidene Derivative, a Novel Antirheumatic Agent, on IL-1 Production
Pharmacological Research, 19933,4-Diacetoxy benzylidene diacetate (ACP) is a prodrug of protocatechualdehyde (PAL). PAL significantly inhibited interleukin-1 (IL-1) production and release in human monocytes in a dose dependent fashion under lipopolysaccharide (LPS) stimulation.
Koju Watanabe, Yo Mori, Haruhisa Hayashi
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Section 2 Clinical experience with fenoprofen, a new antirheumatic agent
Current Medical Research and Opinion, 1974SummaryThe authors review the studies which have been carried out on fenoprofen. Fenoprofen has been demonstrated to have anti-inflammatory, analgesic and antipyretic activity in both animals and man. It is an effective and well tolerated agent in the symptomatic treatment of patients with rheumatoid arthritis, degenerative joint disease, ankylosing ...
Walter M. Mikulaschek +1 more
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Polymeric prodrugs, 5. Dextran‐bound antirheumatic agent naproxen
Die Makromolekulare Chemie, 1986AbstractThe dextran‐bound antirheumatic agent, Naproxen [(+)‐2‐(6‐methoxy‐2‐naphtyl)propionic acid] (3) was synthesized by linking the 2‐aminoethyl ester of Naproxen to the oxydized dextran via an alkylamine bond. The hydrolytic stabilities of modified dextrans were examined viscometrically. The drug release from polymeric prodrug samples containing 68–
Mária Azori +3 more
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The Antirheumatic Agents Sulphasalazine and Methotrexate Share an Anti-Inflammatory Mechanism
Rheumatology, 1995Increasingly, methotrexate (MTX) and sulphasalazine (SASP) are used initially for second-line therapy of rheumatoid arthritis (RA). Although SASP and MTX are commonly used, the mechanism(s) by which these drugs control the inflammation that characterizes RA have remained obscure.
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[Nonsteroidal antirheumatic agents and the gastrointestinal system].
Reumatizam, 1990The antiinflammatory drugs are broadly used also in the treatment of inflammatory and degenerative rheumatic diseases relating to the treatment of extraarticular rheumatism. It has been held that they have an effect in rheumatic diseases even by means of the inhibition of prostaglandins synthesis.
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Antimalarial agents compared with or in combination with other disease-modifying antirheumatic drugs
The American Journal of Medicine, 1988Available published comparisons of antimalarial drugs with other disease-modifying antirheumatic drugs (DMARDs) are reviewed, as well as reports of combinations of DMARDs, in the treatment of rheumatoid arthritis and juvenile rheumatoid arthritis.
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