Results 61 to 70 of about 25,335 (131)

Malignancies and immunoglobulin G4‐related disease

Rheumatology &Autoimmunity, EarlyView.
Immunoglobulin G4‐related disease (IgG4‐RD) is associated with increased cancer risk. Malignancies affect both IgG4‐RD involved organs, such as the lung, pancreas, bile duct, and prostate, and noninvolved organs, such as the gastrointestinal duct. B‐cell neoplasms constitute a proportion of the malignancies linked to this disease.
Jingna Li, Wen Zhang
wiley   +1 more source

Risk of Herpes Zoster in Individuals on Biologics, DMARDS and/or Corticosteroids for Autoimmune Diseases:A Systematic Review and Meta-Analysis [PDF]

, 2016
Background: Studies examining the risk of herpes zoster (HZ) associated with immunosuppressants, such as biologics, non-biological disease modifying agents (nbDMARDs) or corticosteroids, have generated conflicting results.
Alarcón-Segovia, Bachelez, Bejarano, Bongartz, Braun, Brenner, Bresnihan, Cardiel, Che, Chen, Choy, Cohen, Cutolo, Dechartres, Dixon, Dixon, Dreiher, Egger, Emery, Emery, Fleischmann, Fleischmann, Furie, Furst, Galloway, Genovese, Genovese, Gupta, Gupta, Harpaz, Hayward, Higgins, Higgins, Hoes, Kameda, Kawai, Keystone, Kost, Kourbeti, Kremer, Kremer, Kremer, Kremer, Lal, Leonardi, Long, McDonald, Merrill, Moher, Moreland, Moutsopoulos, Nakajima, Nishimoto, Osterman, Oxman, Oxman, Papp, Pappas, Peto, Rutgeerts, Sampathkumar, Sandborn, Sandborn, Schiff, Schreiber, Segan, Shah, Singh, Smitten, Smolen, Smolen, Spittal, Strangfeld, Stroup, Sweeting, Takeuchi, Tanaka, Tanaka, van der Heijde, van Vollenhoven, Veetil, Weiner, Wells, Winthrop, Winthrop, Winthrop, Wolfe, Yamamoto, Yawn, Yawn, Youssef, Yun, Zhang, Zisman, Zorzela   +94 more
core   +1 more source

Co‐prescription of low‐dose methotrexate and trimethoprim‐sulfamethoxazole and the 30‐day risk of death among older adults: A cohort study

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 1263-1271, April 2025.
Abstract Aims The aim of this study was to characterize the risk of death in older adults co‐prescribed low‐dose methotrexate and TMP‐SMX vs. low‐dose methotrexate and a cephalosporin. Methods We conducted a retrospective, population‐based, new‐user cohort study in Ontario, Canada (April 1, 2002–August 1, 2022) using linked administrative healthcare ...
Hasti Sadeghi, Fatemeh Ahmadi, Eric McArthur, Jessica M. Sontrop, Sheikh S. Abdullah, Brad L. Urquhart, Richard B. Kim, Flory T. Muanda   +7 more
wiley   +1 more source

Comparative effectiveness of Tocilizumab with either Methotrexate or Leflunomide in the treatment of rheumatoid arthritis [PDF]

, 2017
Objective: In agreement with EULAR recommendations, a DMARD in combination with a biotherapy is the reference treatment because of the superior long-term clinical and radiographic outcomes. Methotrexate (MTX) is the cornerstone of combination therapy but
Corominas, Héctor, Díaz-Torné, César, Hernández Miguel, María Victoria, Llobet, Josep Maria, Magallares, Berta, Narváez García, Francisco Javier, Nolla Solé, Joan Miquel, Reina, Delia, Rodríguez de la Serna, Arturo, Sanmartí Sala, Raimon   +9 more
core   +1 more source

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis. [PDF]

, 2015
ObjectiveTofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the effects on gene expression in situ are unknown.
Boyle, DL, Bradley, J, Firestein, GS, Hodge, J, Kaplan, I, Kavanaugh, A, Krishnaswami, S, Luo, Z, Mandel, D, Mease, P, Rosengren, S, Shurmur, R, Singhal, AK, Soma, K, Wei, N   +14 more
core  

Understanding cisplatin resistance using cellular models [PDF]

, 2007
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, Mary W., Stordal, Britta
core   +2 more sources

Genetic Profiling Reveals the Distinctions Among MTX‐Associated DLBCL, EBV‐Positive Mucocutaneous Ulcer, and EBV + DLBCL

Cancer Science, EarlyView.
EBV‐ MTX‐DLBCL shows higher driver gene mutation rates and worse outcomes after MTX discontinuation compared to EBV+ MTX‐DLBCL. IDD‐LPDs have lower mutation rates in genes related to clonal hematopoiesis (TET2/DNMT3A) and immune evasion (CD58) compared to EBV + DLBCL. ABSTRACT The WHO recently changed the outline of immunodeficiency/dysregulation (IDD)‐
Takumi Takahashi, Keisuke Sawada, Takahisa Yamashita, Wataru Yamamoto, Yosuke Iijima, Akiko Adachi, Makoto Kashimura, Takayuki Tabayashi, Masahiro Kizaki, Takahiro Kaneko, Jun‐ichi Tamaru, Morihiro Higashi, Shuji Momose   +12 more
wiley   +1 more source

Dental Implant Therapy in Patients With Autoimmune Diseases: A Scoping Review

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives The aim of this scoping review is to determine the effects of autoimmune diseases (ADs) and the agents used for treatment on dental implant survival and biologic outcomes. Material and Methods An electronic database search was performed in MEDLINE (PubMed), The Cochrane Library, and Embase on 29‐04‐2024.
Emil Hyldahl, Henning Schliephake, Simon Storgård Jensen   +2 more
wiley   +1 more source

Evaluation of impaired growth plate development of long bones in skeletally immature mice by antirheumatic agents. [PDF]

J Orthop Res, 2021
Caron MMJ, van Rietbergen B, Castermans TMR, Haartmans MJJ, van Rhijn LW, Welting TJM, Witlox AMA.   +6 more
europepmc   +1 more source

IL‐17 and IL‐23 inhibitors dose spacing in adult psoriatic patients: a real‐world pilot study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives De‐escalation strategies of biologics in psoriasis treatment are widespread in clinical practice. Dose spacing consists of de‐escalating the time range between biological drug injections. Patients and Methods Major objectives were: to describe trends in mean PASI, PASI 100, 90, and ≤ 1 from baseline to 12 months after ...
Luca Mastorino, Paolo Dapavo, Michela Ortoncelli, Eleonora Bongiovanni, Pietro Quaglino, Simone Ribero   +5 more
wiley   +1 more source