Results 81 to 90 of about 3,293,378 (262)

Real‐World Safety Profile of Spesolimab in Generalized Pustular Psoriasis: Insights From Japan as Part of a Multinational Expanded Access Program (EAP)

The Journal of Dermatology, EarlyView.
ABSTRACT Generalized pustular psoriasis (GPP) is a heterogeneous, systemic neutrophilic inflammatory disease, characterized by chronic symptoms and recurrent flares, which can be potentially life‐threatening. Spesolimab, an interleukin‐36 receptor antagonist, has been approved to treat GPP flares in many countries including Japan.
Akimichi Morita, Yayoi Tada, Yuichiro Tsunemi, Mayumi Komine, Takuro Kanekura, Shinichi Imafuku, Toshiya Takahashi, Xuemei Ding, Nichiren Pillai, Morihisa Saitoh, Rafael Sani Simoes, Nora Pöntynen, Keiichi Yamanaka   +12 more
wiley   +1 more source

Making the Old New Again Through the Process of Recombinant Innovation

Journal of Product Innovation Management, EarlyView.
ABSTRACT Academic Summary Recombinant innovation—the process through which atypical and unexpected combinations of knowledge generate novel outcomes—is a critical driver of organizational distinctiveness and market transformation. While prior research has focused on firm‐ and industry‐level mechanisms, less attention has been given to multilevel ...
Vittoria Magrelli, Josip Kotlar, Alfredo De Massis, Federico Frattini, Antonio Messeni Petruzzelli   +4 more
wiley   +1 more source

Periodontal Indices in Patients with Rheumatoid Arthritis Undergoing Immunosuppressive Therapy [PDF]

مجله دانشگاه علوم پزشکی گرگان
Background and Objective: Periodontitis and rheumatoid arthritis are two chronic inflammatory diseases that are interrelated. Given the similarities between these conditions, the medications used by patients with rheumatoid arthritis (RA) may affect ...
Ilnaz Frahoudi, Afsaneh Enteshari-Moghaddam, Zakiyeh Movahedzadeh   +2 more
doaj  

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Clinical Characteristics and Evolution of Interstitial Lung Disease in Subtypes of Idiopathic Inflammatory Myositis With Prevalent Lung Manifestation: A Retrospective Analysis

ACR Open Rheumatology, Volume 8, Issue 2, February 2026.
Objective Interstitial lung disease (ILD) is common in idiopathic inflammatory myositis (IIM), particularly in antisynthetase syndrome (ASyS), antimelanoma differentiation‐associated protein 5 (anti‐MDA5) syndrome, and scleromyositis. ILD can progress despite resolution of extrapulmonary symptoms, termed postmyopathic progressive pulmonary fibrosis ...
Julia Clark, Dora Chan, Damon Dhillon, Jan Dutz, Gillian Goobie, Kun Huang   +5 more
wiley   +1 more source

Trial of a new antirheumatic agent.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974
A double-blind crossover trial of fenoprofen calcium versus acetylsalicylic acid (aspirin) and placebo in 10 outpatients with active rheumatoid arthritis, is reported. Both fenoprofen and aspirin were found to be similarly effective agents in rheumatoid arthritis with an average dose of 2,1 g fenoprofen compared with 4,5 g aspirin.
openaire   +3 more sources

Characteristics of patients with difficult-to-treat rheumatoid arthritis: a descriptive retrospective cohort study

Advances in Rheumatology
Background In 2021, an EULAR task force published a definition of difficult-to-treat rheumatoid arthritis (D2T RA). Our current knowledge of D2T RA with the EULAR definition is based on European and Asian cohorts, and no North American cohort has yet to ...
Wen Qi, Antoine Robert, Narcisse Singbo, Lucie Ratelle, Paul R. Fortin, Louis Bessette, Jacques P. Brown, Laëtitia Michou   +7 more
doaj   +1 more source

Clinico-pharmacological studies and clinical evaluation of flurbiprofen. A new non-steroidal antirheumatic agent. [PDF]

, 1972
Ian Chalmers, B J Cathcart, E.B. Kumar, W C Dick, W. Watson Buchanan   +4 more
openalex   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Janus kinase inhibitor treatment for inflammatory diseases: excess or no excess risk of venous thromboembolism?

Research and Practice in Thrombosis and Haemostasis
Janus kinase inhibitors (JAKis) have revolutionized the treatment landscape for various inflammatory and autoimmune diseases since their introduction in 2012. The expanded indications of JAKis have raised concerns about the associated risk of thrombosis,
Yachar Dawudi, Samuel Benarroch, Hélène Helfer, David M. Smadja, Isabelle Mahé   +4 more
doaj   +1 more source