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SULPHASALAZINE: A ‘NEW’ ANTIRHEUMATIC DRUG [PDF]
Rheumatology, 1984 Sulphasalazine was first introduced for the treatment of rheumatoid arthritis in 1942. Following initial enthusiasm, interest waned until 1978 when a large open study suggested that it might have a 'second-line effect'. Since then further studies have confirmed this effect and once again rheumatologists are starting to use sulphasalazine in the ...
Hilary A Capell, T. Pullar
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The evaluation of antirheumatic drugs
Current Medical Research and Opinion, 1973SummaryThe available methods of evaluation of an antirheumatic compound in a clinical trial situation are discussed. The techniques of single-blind and double-blind studies are described and their respective merits analysed. Proposed new techniques for the measurement of joint inflammation are reviewed.
W. C. Dick +3 more
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Chirality in antirheumatic drugs
The Lancet, 1991Use of chiral molecules in clinical practice may cause problems because different chiral forms of a drug (enantiomers) may have different biological activities--yet clinicians have little awareness of these risks. After discussion of the chemical conventions used to describe chirality, examples of the influence of chirality on the efficacy and toxicity
H. E. Howard-Lock +2 more
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Antirheumatic Drugs in Pregnancy and Lactation
Seminars in Arthritis and Rheumatism, 2005To review the toxicity issues of commonly used antirheumatic drugs in pregnancy and lactation.A review of the medical literature using Medline database via Ovid was performed to identify the toxicities of antirheumatic drugs in pregnancy and lactation.Many rheumatologic diseases in women often first present during the childbearing years. In most cases,
Rama Bandlamudi +2 more
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Antirheumatic drugs in pregnancy and lactation
Baillière's Clinical Rheumatology, 1990The natural inclination of patients with rheumatic diseases wishing to become pregnant or to breast feed will be to take as few medications as possible. The guidelines outlined above can be used to balance the risk of drug effect on the fetus or neonate with the risk of inducing a flare in disease activity by stopping the drug.
Peter Brooks, Christopher J. Needs
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Drugs, 1976
Successful therapy in a chronic rheumatic disease means choosing the right drug for the right patient with the right condition at the right time. In the treatment of gout three different types of treatment are given: for the acute episode, suppression and long-term therapy.
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Successful therapy in a chronic rheumatic disease means choosing the right drug for the right patient with the right condition at the right time. In the treatment of gout three different types of treatment are given: for the acute episode, suppression and long-term therapy.
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Anti-inflammatory and Antirheumatic Drugs
Annals of Internal Medicine, 1981Excerpt Meclofenamate sodium (Meclomen; Parke-Davis, Morris Plains, New Jersey), a nonsteroidal anti-inflammatory agent of the fenamate group, has recently been approved by the U.S.
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Disease-Modifying Antirheumatic Drugs
The Journal of Hand Surgery, 2009S T m f p c In B ri ef ISEASE-MODIFYING ANTIRHEUMATIC drugs (DMARDs) reduce the extent to which rheumatoid arthritis (RA) damages bone and carilage and reduce the disability that results from it. ll patients with RA should receive one or more MARDs as soon as the diagnosis of RA is estabished, because evidence suggests that the long-term utcome is ...
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Evaluating the Antirheumatic Drugs
Annals of Internal Medicine, 1986Excerpt To the editor: The Food and Drug Administration (FDA) has just reported the completion of the first revision of guidelines for the clinical evaluation of nonsteroidal anti-inflammatory and ...
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