Results 31 to 40 of about 21,988 (154)

Associations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to determine whether pollutants such as fire smoke–related particulate matter <2.5 μm (PM2.5) are associated with incident rheumatoid arthritis (RA) and RA‐associated interstitial lung disease (RA‐ILD). Methods This patient–control study used Veterans Affairs (VA) data from October 1, 2009, to December 31, 2018.
Vanessa L. Kronzer, Yangyuna Yang, Punyasha Roul, James L. Crooks, Cynthia S. Crowson, John M. Davis III, Jeffrey A. Sparks, Jeffrey R. Pierce, Katelyn O'Dell, Brian C. Sauer, Grant W. Cannon, Joshua F. Baker, Ted R. Mikuls, Bryant R. England   +13 more
wiley   +1 more source

Genome‐Wide Aggregated Trans Effects Analysis Identifies Genes Encoding Immune Checkpoints as Core Genes for Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes.
Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Megan Sutcliffe, Seema Sharma, Cankut Cubuk, Myles Lewis, Costantino Pitzalis, Anne Barton, Paul M. McKeigue   +9 more
wiley   +1 more source

Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV‐154 in Adults With Glucocorticoid‐Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double‐Blind, Placebo‐Controlled Trial

Arthritis &Rheumatology, EarlyView.
Objective An unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.
Robert F. Spiera, Valerie Devauchelle‐Pensec, Claire E. Owen, Federico Díaz‐González, Tsutomu Takeuchi, Edit Drescher, Jaclyn Anderson, Dilek Arikan, Ronilda D'Cunha, Julie Parmentier, Denise T. Kruzikas, Weihan Zhao, Yang Yang, Karen Stellpflug, Frank Buttgereit   +14 more
wiley   +1 more source

Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA‐ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA‐ILD discrimination beyond clinical and genetic ...
Austin M. Wheeler, Joshua F. Baker, Thomas R. Riley IV, Tate M. Johnson, Yangyuna Yang, Punyasha Roul, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Gail Kerr, Dana P. Ascherman, Paul Monach, Andreas Reimold, Scott Matson, Jill A. Poole, Michael J. Duryee, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +18 more
wiley   +1 more source

Effects of secukinumab on enthesiophyte and erosion progression in psoriatic arthritis –a one‐year double‐blind, randomized, placebo‐controlled trial utilizing high‐resolution peripheral quantitative computed tomography

Arthritis &Rheumatology, Accepted Article.
Objectives This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by high‐resolution peripheral quantitative computed tomography (HR‐pQCT). Methods This was a phase 4, double‐blind, randomized, placebo‐controlled trial.
Yingzhao Jin, Isaac T Cheng, Ho So, Billy T Lai, Shirley K. Ying, Kitty Y. Kwok, James Griffith, Vivian Hung, Cheuk‐Chun Szeto, Jack J. Lee, Ling Qin, Lai‐Shan Tam   +11 more
wiley   +1 more source

Recognition of glycine versus non‐glycine citrulline motifs dictates the HLA class II association of anti‐citrullinated protein antibodies ‐ insights from autoantibody profiling of 6900 Scandinavian rheumatoid arthritis patients

Arthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) associated anti‐citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline‐amino acid motifs, resulting in heterogeneous ACPA‐profiles among patients. Here we analyzed ACPA‐patterns by recognized citrulline‐motifs in relation to the RA risk factors HLA‐DRB1 shared epitope (SE ...
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas‐Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, Swedish Rheumatology Quality Register Biobank Study Group (SRQb), The Danish Rheumatologic Biobank Study Group, Oliver Hendricks, Estrid Høgdall, Tue Wenzel Kragstrup, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Johan Askling, Caroline Grönwall   +31 more
wiley   +1 more source

Incidence of major adverse cardiovascular events in patients with rheumatoid arthritis treated with Janus kinase inhibitors compared to biologic disease‐modifying antirheumatic drugs: data from an international collaboration of registries (the "JAK‐pot" study)

Arthritis &Rheumatology, Accepted Article.
Objective To assess the incidence of major adverse cardiovascular events (MACE) in RA patients treated with JAKi, TNF‐inhibitors (TNFi) or biologic Disease‐Modifying Anti‐Rheumatic Drugs with other modes of action (bDMARD‐OMA) in a multi‐country, real‐world population.
Romain Aymon, Denis Mongin, Romain Guemara, Zubeyir Salis, Johan Askling, Denis Choquette, Catalin Codreanu, Daniela Di Giuseppe, Irini Flouri, Doreen Huschek, Kimme L Hyrich, Florenzo Iannone, Tore K Kvien, Burkhard F Leeb, Dan Nordström, Lucia Otero‐Varela, Karel Pavelka, Manuel Pombo‐Suarez, Ana Rodrigues, Ziga Rotar, Prodromos Sidiropoulos, Sella A Provan, Anja Strangfeld, Trokovic Nina, Jakub Zavada, Lianne Kearsley‐Fleet, Delphine S Courvoisier, Axel Finckh, Kim Lauper   +28 more
wiley   +1 more source

Demonstration of autonomous fixed‐wing drone delivery of prescribed medications in remote islands in Japan

Journal of General and Family Medicine, EarlyView.
We demonstrated a combination of online medication counseling and drone delivery of medications dispensed by pharmacists in two rural clinics located far from pharmacies on remote islands in Japan. After being prescribed by physicians, dispensed by pharmacists, and online medication counseling, the medications were transported by autonomous fixed‐wing ...
Jun Miyata, Hironobu Tsuchiya, Fumiaki Nonaka, Yuji Aso, Masanori Sugahara, Takahiro Maeda   +5 more
wiley   +1 more source

Influence of rheumatoid arthritis on peri‐implant diseases: A longitudinal retrospective clinical and radiographic evaluation

Journal of Periodontology, EarlyView.
Abstract Background To investigate the effect of rheumatoid arthritis (RA) on the incidence of peri‐implantitis (PI) and peri‐implant mucositis (PIM). Methods Radiographic and clinical chart reviews were conducted to measure the probing depth (PD), bleeding on probing, and marginal bone loss (MBL) around the implants to diagnose peri‐implant diseases ...
Hamzeh Almashni, Era Kakar, Paolo Nava, Hom‐Lay Wang, Muhammad H. A. Saleh   +4 more
wiley   +1 more source

Population Pharmacokinetic/Pharmacodynamic and Exposure–Response Modeling of Garadacimab in Healthy Volunteers and Patients With Hereditary Angioedema

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Hereditary angioedema (HAE) is a rare genetic disease that manifests as recurrent, unpredictable, and potentially life‐threatening attacks of angioedema. Garadacimab is a first‐in‐class, fully human, monoclonal antibody targeting activated factor XII (FXIIa) that is under clinical development for the long‐term prophylaxis of HAE attacks.
Ramon Garcia, Shen Cheng, Fiona Glassman, Ankur Sharma, Bernardo De Miguel‐Lillo, Matthew Wiens, Curtis Johnston, John‐Philip Lawo, Ingo Pragst, Jonathan French, Dan Polhamus, Partha Nandy   +11 more
wiley   +1 more source