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Tolerability of antiseizure medications
Neurology, 2004Epilepsy is a disorder of abnormal excitability and synchronicity of aggregates of neurons that lead to paroxysmal behavioral or perceptual change. Most antiepileptic drugs (AEDs) decrease membrane excitability or increase postsynaptic inhibition, and may alter synchronization of neuronal networks.
Frank, Gilliam +2 more
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Polytherapy with Antiseizure Medications
2022Abstract About 40% of patients with epilepsy will have “difficult-to-control” seizures. Focal epilepsies and symptomatic (structural-metabolic) generalized epilepsies are less likely to be controlled easily than the idiopathic (genetic) generalized epilepsies.
Ali A. Asadi-Pooya, Michael R. Sperling
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Antiseizure Medications in the Elderly
2022Abstract Epilepsy is a common neurological problem in the elderly. Seizures in the elderly can be caused by strokes, brain tumors, trauma, infectious causes, toxic and metabolic causes, and degenerative diseases. While similar principles of drug selection apply to elderly individuals and to younger patients, certain factors carry greater
Ali A. Asadi-Pooya, Michael R. Sperling
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Long-Term Effects of Antiseizure Medications
Seminars in Neurology, 2022AbstractMost patients with epilepsy will benefit from seizure control with one of an array of chronic antiseizure medications. Knowledge of the potential long-term effects of these medications is critical to prevent adverse consequences on overall health.
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Starting Antiseizure Medication
2020The goal of starting antiseizure medication (ASM) is for the patient to have no further seizures and no significant side effects. At the time of presentation, additional clinical and laboratory testing is typically needed to determine the risk of seizure recurrence.
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Antiseizure Medications in Patients with Stroke
2022Abstract Stroke and cerebrovascular lesions are the main cause of epilepsy in the elderly. Many similarities exist between cerebral ischemia and epilepsy regarding brain damage and autoprotective mechanisms that are activated following the injurious insult.
Ali A. Asadi-Pooya, Michael R. Sperling
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Antiseizure Medications and Weight Change
2022Abstract Many patients with epilepsy experience weight change after starting an antiseizure medication (ASM). Some ASMs are associated with weight loss, some with weight gain, and others have no effect on weight. Weight gain is associated with an increased risk of comorbidities (e.g., type 2 diabetes mellitus and heart diseases) and ...
Ali A. Asadi-Pooya, Michael R. Sperling
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Update on Antiseizure Medications 2025
ContinuumABSTRACT OBJECTIVE This article is an update from the article on antiseizure medication therapy published in the three previous Continuum issues on epilepsy and is intended to cover the vast majority of agents currently available to neurologists in the management of patients with epilepsy.
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Epilepsia
AbstractDespite the introduction of newer antiseizure medications (ASMs) with improved safety profiles over the past several years, rates of treatment‐related intolerable adverse events (AEs) for people with epilepsy have not changed substantially. Tolerability issues can potentially jeopardize optimal dosing and effectiveness, regimen adherence, and ...
Gregory L. Krauss +2 more
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AbstractDespite the introduction of newer antiseizure medications (ASMs) with improved safety profiles over the past several years, rates of treatment‐related intolerable adverse events (AEs) for people with epilepsy have not changed substantially. Tolerability issues can potentially jeopardize optimal dosing and effectiveness, regimen adherence, and ...
Gregory L. Krauss +2 more
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Withdrawal of Antiseizure Medications
Abstract Withdrawal of antiseizure medications (ASMs) in patients who are seizure free is often of great interest to patients. Given the potential for adverse events on ASMs, it is understandable why many patients hope to come off these medications when seizures appear to be well controlled.Patricia Dugan +2 more
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