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Antiseizure Medications for Adults With Epilepsy
JAMA, 2022Epilepsy affects approximately 65 million people worldwide. Persistent seizures are associated with a 20% to 40% risk of bodily injuries (eg, fractures, burns, concussions) over 12-month follow-up. The primary goal of epilepsy treatment is to eliminate seizures while minimizing adverse effects of antiseizure drugs (ASDs).An epileptic seizure is defined
Andres M, Kanner, Manuel Melo, Bicchi
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Fetal Exposure to Antiseizure Medications
AJN, American Journal of Nursing, 2021According to this study: Cognitive outcomes at two years of age in the language domain of the Bayley Scales of Infant and Toddler Development, Third Edition, didn't differ between children of women with epilepsy and children of healthy women.In adjusted analyses,
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Update on Antiseizure Medications 2022
Continuum, 2022The article "Update on Antiseizure Medications 2022" by Dr Abou-Khalil was first published in the February 2016 Epilepsy issue of Continuum: Lifelong Learning in Neurology as "Antiepileptic Drugs," and at the request of the Editor-in-Chief was updated by Dr Abou-Khalil for the 2019 issue and again for this issue.
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Cardiac adverse effects of antiseizure medications
Expert Opinion on Drug Safety, 2021Patients with severe epilepsy are at increased risk of cardiovascular disease and arrhythmias. Although antiseizure medications (ASMs) may have indirect protective effects against cardiovascular events by reducing seizure frequency and hence sudden death in epilepsy, some of them exert cardiotoxic effects.Patients with epilepsy, mainly those with ...
Gaetano Zaccara +2 more
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Polytherapy with Antiseizure Medications
2022Abstract About 40% of patients with epilepsy will have “difficult-to-control” seizures. Focal epilepsies and symptomatic (structural-metabolic) generalized epilepsies are less likely to be controlled easily than the idiopathic (genetic) generalized epilepsies.
Ali A. Asadi-Pooya, Michael R. Sperling
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Antiseizure Medications in Pregnancy
2022Abstract Due to the potential for teratogenesis and other problems, the risks and benefits of antiseizure medication (ASM) therapy should be weighed carefully in pregnant women or in women of childbearing potential. Pregnancy should be planned in a patient receiving ASMs, so that appropriate measures can be taken in advance.
Ali A. Asadi-Pooya, Michael R. Sperling
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Antiseizure Medications in the Pipeline
2022Abstract More than 30% of people with epilepsy have persistent seizures despite the use of appropriate therapies; these patients have drug-resistant epilepsy. Therefore, investigating and discovering new medications to treat epilepsy is of paramount significance. There are multiple dugs in the pipeline to treat epilepsy.
Ali A. Asadi-Pooya, Michael R. Sperling
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Tolerability of antiseizure medications
Neurology, 2004Epilepsy is a disorder of abnormal excitability and synchronicity of aggregates of neurons that lead to paroxysmal behavioral or perceptual change. Most antiepileptic drugs (AEDs) decrease membrane excitability or increase postsynaptic inhibition, and may alter synchronization of neuronal networks.
Frank, Gilliam +2 more
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Antiseizure Medications in the Elderly
2022Abstract Epilepsy is a common neurological problem in the elderly. Seizures in the elderly can be caused by strokes, brain tumors, trauma, infectious causes, toxic and metabolic causes, and degenerative diseases. While similar principles of drug selection apply to elderly individuals and to younger patients, certain factors carry greater
Ali A. Asadi-Pooya, Michael R. Sperling
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Antiseizure Medications and Cognition
2022Abstract Treating a patient with epilepsy involves more than just treating seizures. Many patients have associated learning and cognitive problems that can lead to significant difficulties at school or work, such as reductions in attention, IQ, language and perceptual skills, executive functions including problem-solving, verbal and ...
Ali A. Asadi-Pooya, Michael R. Sperling
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