Results 261 to 270 of about 1,703,096 (348)

The ZNF148‐ZEB1‐AS1‐IGF2BP2‐NOD2 Axis Drives Microglial Antipneumococcal Immunity in Bacterial Meningitis

Glia, Volume 74, Issue 2, February 2026.
ZNF148 upregulates ZEB1‐AS1, which scaffolds IGF2BP2 to stabilize NOD2 mRNA, enhancing microglial anti‐pneumococcal immunity via cytokine production and bacterial clearance in bacterial meningitis. ABSTRACT Streptococcus pneumoniae (Spn) meningitis remains a lethal central nervous system (CNS) infection with limited therapies. This study identifies the
Xiufu Hu, Fang Jiang, Xinjie Liu, Ling Li, Ruimei Hu, Meng Dong, Aihua Cao   +6 more
wiley   +1 more source

Improving the Cellular Accumulation of Folate-Conjugated Fully Chemically Modified siRNAs via 3' Terminal Conjugation. [PDF]

ACS Omega
Motosawa K, Iwano J, Harumoto T, Yabuuchi H, Hatanaka K, Koda Y, Kubo T, Kodaira H, Uehara K.   +8 more
europepmc   +1 more source

Mitochondrial Transporter ABCB10 Protects Against Doxorubicin‐Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Doxorubicin (DOX) is a highly effective chemotherapeutic agent whose use can cause respiratory toxicity, increasing patient fatigue and negatively impacting quality of life and survival. These adverse effects occur due to diaphragm muscle mitochondrial accumulation of DOX, where it causes reactive oxygen species production and iron ...
Ashley J. Smuder, Vivian Doerr, Cesar E. Jacintho Moritz, Jie Li, Branden L. Nguyen   +4 more
wiley   +1 more source

IT TAKES TWO TO TANGO: potential novel therapies for autosomal dominant optic atrophy. [PDF]

Front Ophthalmol (Lausanne)
Sampige R, Seaborn LEA, Pluenneke M, Jyothi A, Saland S, Chinedu-Obi CM, Keehn C, Lee AG.   +7 more
europepmc   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała, Marta Białobrzeska, Józef Dulak, Urszula Florczyk‐Soluch   +3 more
wiley   +1 more source

Nanomedicine-enhanced delivery of CRISPR-Cas13 for RNA editing in C9orf72-associated ALS. [PDF]

Ann Med Surg (Lond)
Imtiaz E, Mahato RK, Soomro S, Jadoon M, Intikhab S.   +4 more
europepmc   +1 more source

Extracellular Vesicle‐Mediated Delivery of Constrained Peptides Disrupts the Pathogenic Interaction of LRRK2‐FADD in Parkinson's Disease

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT The interaction between mutated leucine‐rich repeat kinase 2 (LRRK2) and the death adaptor protein FADD accounts for apoptotic death of dopaminergic neurons in familial Parkinson's disease (PD) driven by LRRK2 mutations. Disrupting this pathogenic interaction using constrained peptides is a promising therapeutic strategy to mitigate apoptotic ...
Yaochao Zheng, Brian Joseph Jurgielewicz, Leah G Helton, Hardy J Rideout, Eileen J. Kennedy, Steven L Stice, Yao Yao   +6 more
wiley   +1 more source

C16-siRNAs in Focus: Development of ALN-APP, a Promising RNAi-Based Therapeutic for Alzheimer's Disease. [PDF]

Pharmaceuticals (Basel)
Titze-de-Almeida R, Oliveira Gomes GM, Santos TCD, Titze-de-Almeida SS.   +3 more
europepmc   +1 more source

Respiratory Delivery of Highly Conserved Antiviral siRNAs Suppress SARS-CoV-2 Infection. [PDF]

Int J Mol Sci
Zhang Y, Johansen MD, Ledger S, Turville S, Thordarson P, Hansbro PM, Kelleher AD, Ahlenstiel CL.   +7 more
europepmc   +1 more source

Exosome-Mediated Mitochondrial Delivery of Antisense Oligonucleotides

Nucleic Acid Therapeutics
Dora von Trentini, Ivan J. Dmochowski
openaire   +2 more sources