Results 1 to 10 of about 11,877,029 (313)

Improving anti-tumor activity of sorafenib tosylate by lipid- and polymer-coated nanomatrix

Drug Delivery, 2017
In the present study, we select the Sylysia 350 (Sylysia) as mesoporous material, distearoylphosphatidylethanolamine-poly(ethylene glycol)2000 (DSPE-PEG) as absorption enhancer and hydroxy propyl methyl cellulose (HPMC) as crystallization inhibitor to ...
Yang Guo, Ting Zhong, Xiao-Chuan Duan, Shuang Zhang, Xin Yao, Yi-Fan Yin, Dan Huang, Wei Ren, Qiang Zhang, Xuan Zhang   +9 more
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Synthesis and evaluation of cationic polymeric micelles as carriers of lumbrokinase for targeted thrombolysis

Asian Journal of Pharmaceutical Sciences, 2019
To achieve targeted thrombolysis, a targeted delivery system of lumbrokinase (LK) was constructed using RGDfk-conjugated hybrid micelles. Based on the specific affinity of RGDfk to glycoprotein complex of GPⅡb/Ⅲa expressed on the surface of membrane of ...
Yang Pan, Xiahui Wang, Zongning Yin
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Advances in Medical Devices for Augmented Acupuncture Therapy

Advanced Science
Acupuncture, as a traditional medicine applied worldwide, is considered an effective treatment for numerous chronic diseases. Many researches have explored the biological mechanisms of acupuncture, including the skin‐neuro‐immune axis and inflammation ...
Ruisi Cai, Chenyi Yu, Xinyi Luo, Ningyu Xu, Jicheng Yu, Xiao Ye, Yuqi Zhang, Zhen Gu   +7 more
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Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging

Nature Communications, 2022
Detailed quantification of nanoparticle distribution in tumor tissues can provide the prediction of drug delivery efficacy and therapeutic outcome. Here the authors develop a pH/light dual responsive monochromatic ratiometric-imaging nanoparticle which ...
Yue Yan, Binlong Chen, Qingqing Yin, Zenghui Wang, Ye Yang, Fangjie Wan, Yaoqi Wang, Mingmei Tang, Heming Xia, Meifang Chen, Jianxiong Liu, Siling Wang, Qiang Zhang, Yiguang Wang   +13 more
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Comparative study of liposomes and liposomes-in-polymer hydrogel as transdermal carriers for improving the topical delivery of imperatorin

Journal of Holistic Integrative Pharmacy, 2021
[Abstract]: Objective: A novel imperatorin (IMP)-liposome-hydrogel formulation was developed to increase skin permeation efficiency and improve the bioavailability of IMP after topical delivery.
Junfeng BAN, Zhenjie MO, Xuehui CUI, Yuan XU, Zhufen LYU   +4 more
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Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Aim 2-HP-β-cyclodextrin-PLGA nanoparticle complexes were prepared to enhance the aqueous humour delivery of Triamcinolone acetonide.Materials & methods Drug-loaded 2-HP-β-CD/PLGA nanoparticle complexes prepared by adapting a quasi-emulsion solvent ...
Fan Li, Yuqin Wen, Yan Zhang, Kangyu Zheng, Junfeng Ban, Qingchun Xie, Yifeng Wen, Qing Liu, Fohua Chen, Zhenjie Mo, Lizhong Liu, Yanzhong Chen, Zhufen Lu   +12 more
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Identification of beagle food taking patterns and protocol for food effects evaluation on bioavailability

Scientific Reports, 2018
Food is a known primary role to the exposure of the drugs orally administered. Since each animal may have unique food taking pattern and it is difficult to manipulate the food taking to animals, there lacks rationalized protocol for the food effects in ...
Guoqing Zhang, Caifen Wang, Li Wu, Jian Xu, Xiaoxiao Hu, Shailendra Shakya, Yuanzhi He, Xiaohong Ren, Weidong Chen, Jiwen Zhang   +9 more
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Modulating nuclear stiffness and envelope barrier facilitates AAV nuclear entry and reduces immunogenicity

Nature Communications
Recombinant adeno-associated viruses (rAAVs) have shown promise for orthopedic diseases. However, conventional AAV vectors face major challenges, where immune responses reduce transgene efficacy and inadequate vector potency requires higher doses ...
Yangsen Ou, Fuhua Wu, Chunting He, Shuang Luo, Zhaofei Guo, Yongshun Zhang, Rui Hu, Yanhua Xu, Xue Tang, Yuanhao Zhao, Lin Ye, Xiaoyan Chen, Shuting Bai, Guangsheng Du, Xun Sun   +14 more
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Airway administered artificial mitochondria-enriched nanovesicles for efficient and selective mitochondria transfer to intervene in pulmonary fibrosis

Nature Communications
Mitochondrial transplantation is a promising therapeutic approach involving the transfer of exogenous mitochondria into diseased cells to restore impaired mitochondrial homeostasis.
Jinsong Zhang, Siying Fu, Jiawen Wang, Honghui Wu, Zhuoting Li, Ruyi Lin, Hao Sun, Seungho Choe, Yuhuan Kong, Donghang Xu, Jinqiang Wang, Zhen Gu, Jianqing Gao, Tianyuan Zhang   +13 more
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Implantable sandwich PHBHHx film for burst-free controlled delivery of thymopentin peptide

Acta Pharmaceutica Sinica B, 2018
Sustained release and non-parental formulations of peptides and protein drugs are highly desirable because of enhanced therapeutic effects as well as improved patient compliance. This is especially true for small peptides such as thymopentin (TP5).
Ke Peng, Chengyu Wu, Guoxu Wei, Jinghui Jiang, Zhirong Zhang, Xun Sun   +5 more
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