Results 41 to 50 of about 466,787 (269)

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Effect of intratumoral injection on the biodistribution and the therapeutic potential of HPMA copolymer–based drug delivery systems [PDF]

, 2006
The direct intratumoral (i.t.) injection of anticancer agents has been evaluated extensively in the past few decades. Thus far, however, it has failed to become established as an alternative route of administration in routine clinical practice.
Ulbrich, K., Dep Farmaceutische wetenschappen, Peschke, P., Kühnlein, R., Huber, P., Lammers, T., Hennink, W.E., Storm, G., Advanced drug delivery systems/drug targeting, Subr, V.   +9 more
core  

Immunological Risk of Injectable Drug Delivery Systems [PDF]

, 2009
Injectable drug delivery systems (DDS) such as particulate carriers and water-soluble polymers are being used and developed for a wide variety of therapeutic applications.
Schellekens, H., Jiskoot, W., Huub Schellekens, Wim Jiskoot, Rianne M. F. van Schie, Myrra G. Carstens, Carstens, M.G., van Schie, R.M.F.   +7 more
core   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Reduction-sensitive polymers and bioconjugates for biomedical applications [PDF]

, 2009
Reduction-sensitive biodegradable polymers and conjugates have emerged as a fascinating class of biomedical materials that can be elegantly applied for intracellular triggered gene and drug delivery.
Meng, F.H., Zhong, Z., Dep Farmaceutische wetenschappen, Hennink, W.E., Advanced drug delivery systems/drug targeting   +4 more
core  

Pulsed in vitro release and in vivo behavior of exploding microcapsules [PDF]

, 2009
Drug delivery systems which can generate multiple drug pulses after a single injection can be of major importance for e.g. the delivery of vaccines which often require multiple booster injections to generate sufficient immunity.
De Smedt, Stefaan, De Koker, S., De Koker, Stefaan, De Geest, Bruno, Dep Farmaceutische wetenschappen, De Geest, B.G., De Smedt, S.C., Demeester, Jo, Demeester, J., Hennink, WE, Hennink, W.E., Advanced drug delivery systems/drug targeting   +11 more
core   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers [PDF]

, 2009
Copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized polymeric drug carriers that have been broadly implemented in the delivery of anticancer therapeutics.
Ulbrich, K., Huber, P.E., Dep Farmaceutische wetenschappen, Peschke, P., Lammers, T., Hennink, W.E., Storm, G., Advanced drug delivery systems/drug targeting, Subr, V.   +8 more
core  

Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery [PDF]

, 2023
Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and ...
Tatiana Tennikova, Alexey Nikiforov, Evgenia Korzhikova-Vlakh, Mariia Stepanova   +3 more
core   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source