Results 61 to 70 of about 11,877,029 (313)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Structural and functional characterization of self-assembling amphiphilic oligopeptides [PDF]

, 2009
The aim of this thesis was to design amphiphilic peptides that self-assemble into supramolecular structures, like nano-sized vesicles that can be of use for drug delivery purposes.
Dep Farmaceutische wetenschappen, van Hell, A.J., Advanced drug delivery systems/drug targeting   +2 more
core   +1 more source

Herbal Bioactives for Ocular Drug Delivery Systems

, 2022
Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations.
Algın Yapar, Evren; Durgun, Meltem Ezgi; Esentürk, Imren; Güngör, Sevgi; Özsoy, Yıldız.
core   +1 more source

Mucoadhesive drug delivery systems

Journal of Pharmacy And Bioallied Sciences, 2011
Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for ...
Rahamatullah, Shaikh, Thakur, Raj Singh, Garland, M.J., Woolfson, David, Donnelly, Ryan   +4 more
openaire   +4 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Stimuli-responsive biodegradable polymeric micelles for targeted cancer therapy [PDF]

, 2011
Thermosensitive and biodegradable polymeric micelles based on mPEG-b-pHPMAmLacn have shown very promising results during the past years. The results presented in this thesis illustrate the high potential of these micelles for anticancer therapy and ...
Pharmaceutics, Dep Farmaceutische wetenschappen, Sub Drug targeting, Advanced drug delivery systems/drug targeting, Talelli, M.A.   +4 more
core   +1 more source

Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation

Nature Communications
Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this.
Kexin Su, Lu Shi, Tao Sheng, Xinxin Yan, Lixin Lin, Chaoyang Meng, Shiqi Wu, Yuxuan Chen, Yao Zhang, Chaorong Wang, Zichuan Wang, Junjie Qiu, Jiahui Zhao, Tengfei Xu, Yuan Ping, Zhen Gu, Shuai Liu   +16 more
doaj   +1 more source

Preparation of TPM–NCs–gel and its effect on subcutaneous abscess caused by Staphylococcus aureus

Journal of Holistic Integrative Pharmacy
Objective: The insoluble compound 1,1′-(2,4,6-trihydroxy-1,3-phenylene)bis(3-methylbutan-1-one) (TPM) is used in preparing a TPM nanocrystals gel (TPM–NCs–gel), and its in vitro antibacterial activity and therapeutic effect on subcutaneous abscesses ...
Quanwei Xie, Feirong Zhou, Runan He, Lianbao Ye, Zonghao Lin, Xiangyu Nie, Yuanzheng Wei, Chuqin Yu   +7 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Advanced Drug Delivery Strategies for Overcoming Biological Barriers: Tumor Microenvironment and Blood–Brain Barrier

Drugs in R&D
Therapeutic efficacy for malignancies and neurological disorders is fundamentally restricted by biological barriers, particularly the complex tumor microenvironment (TME) and selective blood–brain barrier (BBB).
Yicong Lei, Tingyu Xiao, Xin Hu, Huaqing Lin   +3 more
doaj   +1 more source