Results 61 to 70 of about 12,600,324 (312)

Scarless wound healing programmed by core-shell microneedles

Nature Communications, 2023
Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages.
Ying Zhang, Shenqiang Wang, Yinxian Yang, Sheng Zhao, Jiahuan You, Junxia Wang, Jingwei Cai, Hao Wang, Jie Wang, Wei Zhang, Jicheng Yu, Chunmao Han, Yuqi Zhang, Zhen Gu   +13 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emulsion and Emulgel-Based Ophthalmic Drug Delivery Systems [PDF]

Ophthalmic drug delivery encounters unique challenges due to the anatomical and physiological ocular barriers, necessitating the development of novel drug delivery systems (NDDSs).
Yang, Eleen, Mohapatra, Debadatta, Corson, Timothy W., Eleen Yang, Debadatta Mohapatra, Timothy W. Corson   +5 more
core   +1 more source

HERBAL NOVEL DRUG DELIVERY SYSTEMS AND TRANSFERSOMES [PDF]

, 2018
The strength of any herbal formulation depends on the delivery of phytoactives to an effective level. This limitation can be overcome by development of novel drug delivery systems, which ensure optimized drug delivery, enhanced bioavailability and better
Tyagi, Bharat Kumar, Pradeep Chauhan, Bharat Kumar Tyagi, Chauhan, Pradeep   +3 more
core   +1 more source

Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery

, 2023
Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition and architecture can vary over a wide range. Their unique ability to form secondary structures, as well as different pathways of modification and ...
Tatiana Tennikova, Alexey Nikiforov, Evgenia Korzhikova-Vlakh, Mariia Stepanova   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation

Nature Communications
Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this.
Kexin Su, Lu Shi, Tao Sheng, Xinxin Yan, Lixin Lin, Chaoyang Meng, Shiqi Wu, Yuxuan Chen, Yao Zhang, Chaorong Wang, Zichuan Wang, Junjie Qiu, Jiahui Zhao, Tengfei Xu, Yuan Ping, Zhen Gu, Shuai Liu   +16 more
doaj   +1 more source

Preparation of TPM–NCs–gel and its effect on subcutaneous abscess caused by Staphylococcus aureus

Journal of Holistic Integrative Pharmacy
Objective: The insoluble compound 1,1′-(2,4,6-trihydroxy-1,3-phenylene)bis(3-methylbutan-1-one) (TPM) is used in preparing a TPM nanocrystals gel (TPM–NCs–gel), and its in vitro antibacterial activity and therapeutic effect on subcutaneous abscesses ...
Quanwei Xie, Feirong Zhou, Runan He, Lianbao Ye, Zonghao Lin, Xiangyu Nie, Yuanzheng Wei, Chuqin Yu   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Vesicular drug delivery systems: A novel approach for drug targeting [PDF]

, 2013
The objective of the study is to evaluate the potential of novel vesicular drug delivery systems for drug targeting. Novel vesicular drug delivery systems aim to deliver the drug at a rate directed by need of body during the period of treatment, and ...
Nancy Magon, Suman Bala, Vikas Jhawat, Sunil Kamboj, Vipin Saini   +4 more
core