Results 81 to 90 of about 1,036,500 (313)

Advanced Drug Delivery Strategies for Overcoming Biological Barriers: Tumor Microenvironment and Blood–Brain Barrier

Drugs in R&D
Therapeutic efficacy for malignancies and neurological disorders is fundamentally restricted by biological barriers, particularly the complex tumor microenvironment (TME) and selective blood–brain barrier (BBB).
Yicong Lei, Tingyu Xiao, Xin Hu, Huaqing Lin   +3 more
doaj   +1 more source

Polymeric biomaterials for the delivery of platinum-based anticancer drugs [PDF]

, 2018
Since cisplatin, cis-diamminedichloroplatinum(II), received FDA approval for use in cancer treatment in 1978, platinum-based drugs have been one of the most widely used drugs for the treatment of tumors in testicles, ovaries, head and neck.
Kim, J, Kim, WJ, Lee, D, Park, H, Pramanick, S   +4 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Periodic asymmetric field enhances electrofusion of nanoscale lipid systems

Nature Communications
Electrofusion is a widely used technique for inducing membrane merging in biological systems, with applications ranging from hybrid lipid architectures to therapeutic delivery.
Honghui Wu, Wen-Che Liu, Xuanyu Wu, Zhuoting Li, Jialu Zhang, Jiawen Wang, Qing Zhu, Jinsong Zhang, Kairu Dong, Ruyi Lin, Huihui Hu, Junjie Zeng, Jiaying Wu, Kan Li, Kewang Nan, Tianyuan Zhang, Jianqing Gao   +16 more
doaj   +1 more source

Synthesis of HA-SS-MP: A Prodrug With High Specificity for Cancer Cells

Natural Product Communications, 2020
Thiolated hyaluronic acid was synthesized, and a quantification method was established to determine the content of the thiol group. Three thiol compounds, 2-nitro-5-mercapto-benzoic acid (TNB), 2- mercaptonicotinic acid (2-MNA), and mercaptopyridine (MPD)
Bo Tao, Zong-ning Yin
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Materials in particulate form for tissue engineering. 1 Basic concepts [PDF]

, 2007
For biomedical applications, materials small in size are growing in importance. In an era where ‘nano’ is the new trend, micro- and nano-materials are in the forefront of developments.
Abazinge, Abraham, Ain, Allemann, Araújo, Arica, Arnedo, Artzi, Attebery, Azevedo, Bajpai, Baldwin, Balla, Baran, Bender, Berkland, Berthold, Berton, Bezemer, Bezemer, Birnbaum, Bissery, Boesel, Borlongan, Bowersock, Brannon-Peppas, Brasseur, Brekke, Brigger, Brigger, Brown, Buntner, Caputo, Carrascosa, Cavalieri, Cavanagh, Cerchiara, Chellat, Chen, Chinen, Chu, Chu, Coppi, Couvreur, Cruaud, Cui, Cuthbertson, Dalpiaz, Day, de Groot, De Jaeghere, De Rosa, Delie, Demers, Diwan, Domingues, Doyle, Dubertnet, Duchêne, Duclairoir, Elbahri, Eliaz, Elvira, Engelmann, Ertl, Espigares, Esposito, Fahlvik, Falaize, Fawaz, Ferreiro, Fidler, Frazzati-Gallina, Friess, Fundueanu, Ganza-Gonzalez, Gaspar, Gatti, Genzel, Ghaderi, Ghassabian, Gibaud, Gibaud, Gibaud, Gombotz, Gomes, Gomes, Gosain, Grassi, Grayson, Gref, Gref, Gu, Guicheux, Gárcia Del Barrio, Han, Hedberg, Henry-Michelland, Heritage, Herrmann, Herrmann, Holland, Hollinger, Hollinger, Hong, Hoshino, Hrkach, Hu, Huang, Huang, Humphrey, Huygh, Iooss, Isobe, Isobe, Jain, Jalón, Janes, Janes, Jeong, Jeong, Jiang, Jiao, Jollivet, Jung, Kamyshny, Katare, Kato, Kawaguchi, Keegan, Keshaw, Kidane, Kim, Kim, Kim, Kim, King, Kirker-Head, Klibanov, Knowles, Knowles, Ko, Kobayashi, Kojima, Komlev, Koosha, Koosha, Kreuter, Kreuter, Kreuter, Kriwet, Kumar, Kumar, Labhasetwar, Lam, Langer, Le Ray, Lee, Lee, Li, Li, Li, Lim, Lin, Lin, Liu, Liu, Lyoo, Madan, Maeda, Maeda, Malda, Malda, Mao, Marques, Marty, Matsumoto, Matzelle, Maysinger, Meenen, Meinel, Melero-Martin, Mendes, Mendes, Miller, Misirli, Mittal, Moner-Girona, Moore, Morishita, Morita, Morlock, Morlock, Mu, Murillo, Na, Na, Nakaoka, Narayani, Nathan, Nicoll, Nishikawa, Nitsch, Norton, Nykamp, O'Donnel, Ohagan, Ohagan, Orive, Orive, Pan, Payne, Payne, Peracchia, Pereswetoff-Morath, Perets, Perez, Perugini, Pillai, Pillai, Piskin, Pitt, Podual, Ponchel, Pérez, Qiu, Qiu, Qiu, Rabanel, Reis, Ricci, Rocca, Rodrigues, Ronneberger, Rossler, Rydell, Safarikova, Saito, Salgado, Sanchez, Santinho, Santos, Santos, Schaffazick, Schepers, Schepers, Schepers, Schepers, Schlapp, Seal, Sendil, Shahidi, Shi, Shinkai, Siepmann, Silva, Silva, Silva, Silvio, Singh, Singh, Sivakumar, Smidsrød, Somavarapu, Song, Soppimath, Spegel, Stenekes, Stertman, Streubel, Sturesson, Suckow, Sugiura, Swatschek, Takada, Tamilvanan, Tamilvanan, Tamura, Tao, Tatard, Thomson, Tinsley-Brown, Tiourina, Touvinen, Tu, Tuncel, Ueda, van der Lubben, Vaz, Voigt, Walter, Wang, Wang, Wartlick, Wei, Weinhold, Weng, Whang, Wikingsson, Williams, Winn, Xu, Yamazaki, Yan, Yang, Yang, Yasugi, Yenice, Yokomizo, Youan, Zeller, Zerbo, Zhang, Zhang, Zhang, Zhu, Zignani, Zimmer   +317 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Supramolecular Nano‐Grid Platform to Load and Deliver Liposomes and Exosomes

Small Structures
In general, carriers are designed to deliver pharmaceutical (featuring small drug‐molecules) and biopharmaceutical (featuring large‐molecule drugs, e.g., antibodies, proteins, etc.) active ingredients and platform that is capable of transporting ...
Jing Li, Wuzhen Ma, Xiaohong Ren, Tao Guo, Boyang Yang, Chenxi Huang, Ting Xiong, Yuhua Guo, Zeru Li, Siwen Wang, Bingqian Jia, Shujun Wang, Li Wu, Jiwen Zhang   +13 more
doaj   +1 more source

Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma

Acta Pharmaceutica Sinica B, 2019
Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy.
Xi Cao, Ying Hu, Shi Luo, Yuejing Wang, Tao Gong, Xun Sun, Yao Fu, Zhirong Zhang   +7 more
doaj   +1 more source