Results 1 to 10 of about 3,655,896 (303)

The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. [PDF]

PLoS ONE, 2016
In this study the effects of a new, highly selective sodium-calcium exchanger (NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca2+ transients, cell shortening and in experimental arrhythmias.
Zsófia Kohajda, Nikolett Farkas-Morvay, Norbert Jost, Norbert Nagy, Amir Geramipour, András Horváth, Richárd S Varga, Tibor Hornyik, Claudia Corici, Károly Acsai, Balázs Horváth, János Prorok, Balázs Ördög, Szilvia Déri, Dániel Tóth, Jouko Levijoki, Piero Pollesello, Tuula Koskelainen, Leena Otsomaa, András Tóth, István Baczkó, István Leprán, Péter P Nánási, Julius Gy Papp, András Varró, László Virág   +25 more
doaj   +1 more source

The bioavailability of a paediatric sustained-action theophylline capsule

South African Family Practice, 1985
No abstract available.
R.S. Summers
doaj   +1 more source

Pharmacological Modulation of Hif-1α in the Cerebral Cortex of Rats after Chronic Prenatal Hypoxia

Biology and Life Sciences Forum, 2022
Despite the significant advances in modern medicine, the problem of perinatal hypoxic CNS damage in children occupies one of the leading places in modern neonatology.
Olena G. Aliyeva, Igor F. Belenichev, Olena O. Popazova, Galina A. Zidrashko   +3 more
doaj   +1 more source

Study on Neuromuscular Blockade Action of Verapamil in Albino Rats [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Calcium Channel Blockers (CCBs) are now widely employed in the treatment of cardiovascular diseases and peri-operative hypertension. It has been reported that calcium channel blockers inhibit neuromuscular transmission.
JAYASHREE NAGARAL, SHASHIKALA GH, JAGADEESH K, SHARATH KUMAR K, JAYANTH GS, CHENNAVEERAPPA PK, RAJANI PATIL   +6 more
doaj   +1 more source

Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways. [PDF]

PLoS ONE, 2010
Proving the efficacy and corresponding mode of action of herbal supplements is a difficult challenge for evidence-based herbal therapy. A major hurdle is the complexity of herbal preparations, many of which combine multiple herbs, particularly when the ...
Young-Beob Yu, Laura Dosanjh, Lixing Lao, Ming Tan, Bum Sang Shim, Yuan Luo   +5 more
doaj   +1 more source

Hollow microneedles as a flexible dosing control solution for transdermal drug delivery

Materials Today Bio
Microneedles, small needle-like structures typically less than 1000 μm in length, are effective tools for transporting substances across biological barriers via minimally invasive pathways.
Jongwon Kim, Jaeheon Jeong, Jung Ki Jo, Hongyun So   +3 more
doaj   +1 more source

Case Report: Atypical neuroleptic malignant syndrome induced by paliperidone palmitate—diagnostic challenges and clinical considerations

Frontiers in Psychiatry
Poor treatment adherence is common in schizophrenia and constitutes a major risk factor for relapse and clinical instability. Long-acting injectable (LAI) antipsychotics are frequently prescribed to mitigate this risk; however, their use can be ...
Omar El Oumary, Omar El Oumary, Hicham Laaraj, Mina Ouhamou, Khalid Mouhadi, Jalal Doufik, Jalal Doufik, Khadija Akebour, Khadija Akebour, Saliha Hamri, Ismail Rammouz, Ismail Rammouz   +11 more
doaj   +1 more source

Complex View on Poisoning with Nerve Agents and Organophosphates

Acta Medica, 2005
OP/nerve agents are still considered as important chemicals acting on living organisms and widely used in human practice. Nerve agents are the most lethal chemical warfare agents.
Jiří Bajgar
doaj   +1 more source

Comparative analysis of the effectiveness of chondroitin sulfate, hyaluronic acid and arthroscopy at the initial stages of hip osteoarthritis

Bolʹ, Sustavy, Pozvonočnik, 2017
Background. The efficiency of modern drugs that modify the course of the disease is still doubtful, especially, their influence on the long-term effects of hip osteoarthritis.
V.G. Lutsyshyn, A.V. Kalashnikov, O.V. Maiko, V.M. Maiko   +3 more
doaj   +1 more source

The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review

Children
Background: To date, it remains unclear which oral doses and preparation forms of melatonin should be recommended for children and adolescents with non-organic sleep disorders and autism spectrum disorder (ASD). We reviewed the current state of knowledge
Ekkehart Paditz, Bertold Renner, Rainer Koch, Barbara M. Schneider, Angelika A. Schlarb, Osman S. Ipsiroglu   +5 more
doaj   +1 more source