Results 31 to 40 of about 169,421 (298)

Time Course of the Increase in the Myocardial Slow Inward Current after a Photochemically Generated Concentration Jump of Intracellular cAMP [PDF]

, 1983
Voltage-clamped atrial trabeculae from bullfrog hearts were exposed to membrane-permeant photolyzable o-nitrobenzyl esters of cAMP and cGMP. UV flashes produced intracellular concentration jumps of cAMP or cGMP. With the cAMP derivative, flashes resulted
Engels, Joachim, Lester, Henry A., Nargeot, Joel, Nerbonne, Jeanne M.   +3 more
core   +1 more source

Neural Correlates of Swimming Behavior in Melibe leonina [PDF]

, 2002
The nudibranch Melibe leonina swims by rhythmically bending from side to side at a frequency of 1 cycle every 2–4 s. The objective of this study was to locate putative swim motoneurons (pSMNs) that drive these lateral flexions and determine if swimming ...
Newcomb, James M., Thompson, Stuart, Watson, Winsor H., III   +2 more
core   +2 more sources

Pharmacological Significance of the Blocking Action of the Intravenous General Anesthetic Propofol on the Slow Component of Cardiac Delayed Rectifier K+ Current

Journal of Pharmacological Sciences, 2009
.: Propofol is a widely used intravenous general anesthetic. The negative inotropic effect of propofol has been best explained by inhibition of the L-type Ca2+ current (ICa).
Noboru Hatakeyama, Fumika Sakuraya, Naoyuki Matsuda, Junko Kimura, Hiroyuki Kinoshita, Osamu Kemmotsu, Mitsuaki Yamazaki, Yuichi Hattori   +7 more
doaj   +1 more source

Pharmacological Modulation of Hif-1α in the Cerebral Cortex of Rats after Chronic Prenatal Hypoxia

Biology and Life Sciences Forum, 2022
Despite the significant advances in modern medicine, the problem of perinatal hypoxic CNS damage in children occupies one of the leading places in modern neonatology.
Olena G. Aliyeva, Igor F. Belenichev, Olena O. Popazova, Galina A. Zidrashko   +3 more
doaj   +1 more source

Study on Neuromuscular Blockade Action of Verapamil in Albino Rats [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Calcium Channel Blockers (CCBs) are now widely employed in the treatment of cardiovascular diseases and peri-operative hypertension. It has been reported that calcium channel blockers inhibit neuromuscular transmission.
JAYASHREE NAGARAL, SHASHIKALA GH, JAGADEESH K, SHARATH KUMAR K, JAYANTH GS, CHENNAVEERAPPA PK, RAJANI PATIL   +6 more
doaj   +1 more source

Fermented mistletoe extract as a multimodal antitumoral agent in gliomas [PDF]

, 2012
In Europe, commercially available extracts from the white-berry mistletoe (Viscum album L.) are widely used as a complementary cancer therapy. Mistletoe lectins have been identified as main active components and exhibit cytotoxic effects as well as ...
Harter, Patrick Nikolaus, Mittelbronn, Michel Guy André, Naumann, Ulrike, Podlech, Oliver, Pöschel, Simone   +4 more
core   +2 more sources

Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways. [PDF]

PLoS ONE, 2010
Proving the efficacy and corresponding mode of action of herbal supplements is a difficult challenge for evidence-based herbal therapy. A major hurdle is the complexity of herbal preparations, many of which combine multiple herbs, particularly when the ...
Young-Beob Yu, Laura Dosanjh, Lixing Lao, Ming Tan, Bum Sang Shim, Yuan Luo   +5 more
doaj   +1 more source

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. [PDF]

, 2012
The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Brunger, Axel T, Chu, Steven, Cipriano, Daniel J, Diao, Jiajie, Grob, Patricia, Kyoung, Minjoung, Nguyen, Amie, Nogales, Eva, Padolina, Mark, Shah, Ankita, Shah, Sachi, Srivastava, Ankita, Vrljic, Marija, Zhang, Yunxiang   +13 more
core   +1 more source

Hollow microneedles as a flexible dosing control solution for transdermal drug delivery

Materials Today Bio
Microneedles, small needle-like structures typically less than 1000 μm in length, are effective tools for transporting substances across biological barriers via minimally invasive pathways.
Jongwon Kim, Jaeheon Jeong, Jung Ki Jo, Hongyun So   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source