Results 21 to 30 of about 56,045 (301)

U.S. patient preferences for long‐acting HIV treatment: a discrete choice experiment

Journal of the International AIDS Society, 2023
Introduction Recent advances in long‐acting antiretroviral therapy (LA‐ART) could provide new options for HIV treatment and reduce adherence barriers, if regimens are acceptable to patients.
Susan M. Graham, Douglas Barthold, Brett Hauber, Aaron T. Brah, Enrique Saldarriaga, Ann C. Collier, Rodney J. Y. Ho, the Emory PREFER Team, Vincent C. Marconi, Jane M. Simoni   +9 more
doaj   +1 more source

Concerns regarding tablet splitting: a systematic review

BJGP Open, 2022
Background: Tablet splitting can provide dose flexibility and cost savings; however, pharmaceutical representatives typically discourage the practice. Aim: To identify and summarise all published concerns related to tablet splitting and to present the ...
Aanchal K Saran, Natalie A Holden, Scott R Garrison   +2 more
doaj   +1 more source

Acetylcholine Reduces I_Kr and Prolongs Action Potentials in Human Ventricular Cardiomyocytes

Biomedicines, 2022
Vagal nerve stimulation (VNS) has a meaningful basis as a potentially effective treatment for heart failure with reduced ejection fraction. There is an ongoing VNS randomized study, and four studies are completed.
István Koncz, Arie O. Verkerk, Michele Nicastro, Ronald Wilders, Tamás Árpádffy-Lovas, Tibor Magyar, Noémi Tóth, Norbert Nagy, Micah Madrid, Zexu Lin, Igor R. Efimov   +10 more
doaj   +1 more source

Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Ibrutinib and acalabrutinib are Bruton tyrosine kinase inhibitors used in the treatment of B‐cell lymphoproliferative disorders. Ibrutinib is associated with new‐onset atrial fibrillation.
Jari M. Tuomi, Loryn J. Bohne, Tristan W. Dorey, Hailey J. Jansen, Yingjie Liu, Douglas L. Jones, Robert A. Rose   +6 more
doaj   +1 more source

Effect of a delayed-action phenytoin preparation on blood phenytoin concentration [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1972
In a cross-over study in a group of epileptic patients it was shown that replacement of the evening dose of an ordinary phenytoin preparation with the same phenytoin dose in a delayed-action preparation produced no significant change in the next morning's mean blood phenytoin concentration.
F, Bochner, W D, Hooper, J H, Tyrer, M J, Eadie   +3 more
openaire   +2 more sources

Long-acting antipsychotic drugs for the treatment of schizophrenia: use in daily practice from naturalistic observations

BMC Psychiatry, 2012
Background Current guidelines suggest specific criteria for oral or long-acting injectable antipsychotic drugs (LAIs). This review aims to describe the demographic and clinical characteristics of the ideal profile of the patient with schizophrenia ...
Rossi Giuseppe, Frediani Sonia, Rossi Roberta, Rossi Andrea   +3 more
doaj   +1 more source

Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay [PDF]

, 2008
Introduction: We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy ...
Borelli, Claudia, Fluhr, J. W., Korting, Hans Christian, Schinzel, S., Gassmueller, J., Nietsch, K. H.   +5 more
core   +1 more source

Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome [PDF]

, 2011
The short QT syndrome (SQTS) is a genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death.
Hancox Jules C., McPate, Mark J., Mark J McPate, Hancox, Jules C., Witchel, HJ, Witchel Harry J., Witchel, Harry J., Ismail Adeniran, Zhang, H., Hancox, JC, McPate, MJW, Henggui Zhang (74233), Ismail Adeniran (192479), Adeniran, I., Adeniran, Ismail, Zhang Henggui, Adeniran Ismail, Zhang, Henggui, Henggui Zhang, Jules C Hancox, Harry Witchel (4462174), Jules C Hancox (16149998), McPate Mark J., Mark J McPate (16150001), Harry J Witchel   +24 more
core   +1 more source

Health care use, drug treatment and comorbidity in patients with schizophrenia or non-affective psychosis in Sweden: a cross-sectional study

BMC Psychiatry, 2017
Background This study investigated the prevalence of schizophrenia (ICD-10 F 20) and of other non-affective psychosis (NAP, ICD-10 F 21 - F 29) in Sweden. It further assessed health care use, comorbidity and medication for these patient groups.
Erica M. Brostedt, Mussie Msghina, Marie Persson, Björn Wettermark   +3 more
doaj   +1 more source

Forskolin suppresses delayed-rectifier K+ currents and enhances spike frequency-dependent adaptation of sympathetic neurons. [PDF]

PLoS ONE, 2015
In signal transduction research natural or synthetic molecules are commonly used to target a great variety of signaling proteins. For instance, forskolin, a diterpene activator of adenylate cyclase, has been widely used in cellular preparations to ...
Luis I Angel-Chavez, Eduardo I Acosta-Gómez, Mario Morales-Avalos, Elena Castro, Humberto Cruzblanca   +4 more
doaj   +1 more source