Results 21 to 30 of about 3,655,896 (303)

U.S. patient preferences for long‐acting HIV treatment: a discrete choice experiment

Journal of the International AIDS Society, 2023
Introduction Recent advances in long‐acting antiretroviral therapy (LA‐ART) could provide new options for HIV treatment and reduce adherence barriers, if regimens are acceptable to patients.
Susan M. Graham, Douglas Barthold, Brett Hauber, Aaron T. Brah, Enrique Saldarriaga, Ann C. Collier, Rodney J. Y. Ho, the Emory PREFER Team, Vincent C. Marconi, Jane M. Simoni   +9 more
doaj   +1 more source

Acetylcholine Reduces I_Kr and Prolongs Action Potentials in Human Ventricular Cardiomyocytes

Biomedicines, 2022
Vagal nerve stimulation (VNS) has a meaningful basis as a potentially effective treatment for heart failure with reduced ejection fraction. There is an ongoing VNS randomized study, and four studies are completed.
István Koncz, Arie O. Verkerk, Michele Nicastro, Ronald Wilders, Tamás Árpádffy-Lovas, Tibor Magyar, Noémi Tóth, Norbert Nagy, Micah Madrid, Zexu Lin, Igor R. Efimov   +10 more
doaj   +1 more source

Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Ibrutinib and acalabrutinib are Bruton tyrosine kinase inhibitors used in the treatment of B‐cell lymphoproliferative disorders. Ibrutinib is associated with new‐onset atrial fibrillation.
Jari M. Tuomi, Loryn J. Bohne, Tristan W. Dorey, Hailey J. Jansen, Yingjie Liu, Douglas L. Jones, Robert A. Rose   +6 more
doaj   +1 more source

Effect of a delayed-action phenytoin preparation on blood phenytoin concentration [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1972
In a cross-over study in a group of epileptic patients it was shown that replacement of the evening dose of an ordinary phenytoin preparation with the same phenytoin dose in a delayed-action preparation produced no significant change in the next morning's mean blood phenytoin concentration.
F, Bochner, W D, Hooper, J H, Tyrer, M J, Eadie   +3 more
openaire   +2 more sources

Class I Gap-formation in Highly-viscous Glass-ionomer Restorations: Delayed vs Immediate Polishing [PDF]

, 2008
This in vitro study evaluated the effects of delayed versus immediate polishing to permit maturation of interfacial gap-formation around highly viscous conventional glass-ionomer cement (HV-GIC) in Class I restorations, together with determining the ...
Maruo, Yukinori, Suzuki, Kazuomi, Watts, David C, Nishgawa, Goro, Watts, David C.; id_orcid, Irie, Masao   +5 more
core   +1 more source

Long-acting antipsychotic drugs for the treatment of schizophrenia: use in daily practice from naturalistic observations

BMC Psychiatry, 2012
Background Current guidelines suggest specific criteria for oral or long-acting injectable antipsychotic drugs (LAIs). This review aims to describe the demographic and clinical characteristics of the ideal profile of the patient with schizophrenia ...
Rossi Giuseppe, Frediani Sonia, Rossi Roberta, Rossi Andrea   +3 more
doaj   +1 more source

Health care use, drug treatment and comorbidity in patients with schizophrenia or non-affective psychosis in Sweden: a cross-sectional study

BMC Psychiatry, 2017
Background This study investigated the prevalence of schizophrenia (ICD-10 F 20) and of other non-affective psychosis (NAP, ICD-10 F 21 - F 29) in Sweden. It further assessed health care use, comorbidity and medication for these patient groups.
Erica M. Brostedt, Mussie Msghina, Marie Persson, Björn Wettermark   +3 more
doaj   +1 more source

Forskolin suppresses delayed-rectifier K+ currents and enhances spike frequency-dependent adaptation of sympathetic neurons. [PDF]

PLoS ONE, 2015
In signal transduction research natural or synthetic molecules are commonly used to target a great variety of signaling proteins. For instance, forskolin, a diterpene activator of adenylate cyclase, has been widely used in cellular preparations to ...
Luis I Angel-Chavez, Eduardo I Acosta-Gómez, Mario Morales-Avalos, Elena Castro, Humberto Cruzblanca   +4 more
doaj   +1 more source

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]

, 2005
Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Lengyel, Csaba Attila, Varró, András, Takács, János, Bogáts, Gábor, Nagy, Zsolt, Lathrop, David A., Biliczki, Péter, Bitay, Miklós, Jost, Norbert, Virág, László, Papp, Gyula   +10 more
core   +1 more source

Diabetes mellitus attenuates the repolarization reserve in mammalian heart [PDF]

, 2007
Objective: In diabetes mellitus several cardiac electrophysiological parameters are known to be affected. In rodent experimental diabetes models changes in these parameters were reported, but no such data are available in other mammalian species ...
Lengyel, Csaba Attila, Papp, Julius Gyula, Biliczki, Péter, Tóth, Miklós, Jost, Norbert, Nánási, Péter Pál, Virág, László, Kocsis, Erzsébet, Varró, András, Bíró, Tamás, Skoumal, Réka, Kecskeméti, Valéria, Magyar, János   +12 more
core   +1 more source