Journal of Pharmacological Sciences, 2009 .: Propofol is a widely used intravenous general anesthetic. The negative inotropic effect of propofol has been best explained by inhibition of the L-type Ca2+ current (ICa).
Noboru Hatakeyama +7 more
doaj +4 more sources
Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve. [PDF]
PLoS ONE, 2012 BACKGROUND: The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti-inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle.
Attila Kristóf +11 more
doaj +3 more sources
N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes. [PDF]
PLoS ONE, 2011 BACKGROUND AND OBJECTIVE: The slow delayed rectifier current (I(Ks)) is important for cardiac action potential termination. The underlying channel is composed of Kv7.1 α-subunits and KCNE1 β-subunits.
Zenawit Girmatsion +5 more
doaj +2 more sources
Once-Daily Extended-Release Levetiracetam Improves Medication Compliance in Adolescent Epilepsy Patients [PDF]
Annals of Child Neurology, 2021 Purpose Since pharmacologic agents are the mainstay of epilepsy treatment, drug compliance is one of the most important factors in seizure control. Once-daily levetiracetam (LEV) has been proven to have the same efficacy as that of an immediate-release ...
Seung Yeon Jung +2 more
doaj +1 more source
Retrospective analysis of hospitalization rates in patients with schizophrenia 12 months before and 12 months after the switch on once-monthly long-acting injectable paliperidone palmitate [PDF]
Vojnosanitetski Pregled, 2023 Background/Aim. There is no available published data about the use of long-acting injectable paliperidone palmitate (PP) in schizophrenia patients in the Republic of Serbia.
Totić-Poznanović Sanja +1 more
doaj +1 more source
Adherence to depot versus oral antipsychotic medication in schizophrenic patients during the long-term therapy [PDF]
Vojnosanitetski Pregled, 2013 Background/Aim. There is a high rate of schizophrenic patients who do not adhere to their prescribed therapy, despite the implementation of antipsychotic long-acting injections and the introduction of atypical antipsychotics. The aim of this study was
Stanković Žana, Ille Tatjana
doaj +1 more source
A comparative analysis of the influence of different types of Carbopol® on the release rate of lithium-carbonate from matrix tablets [PDF]
Vojnosanitetski Pregled, 2012 Background/Aim. Hydrophilic matrix tablets represent the most commonly used oral dosage form. Carbomers used in the concentration of 10%-30% for preparation of matrix tablets, may significantly affect the profile of drug release due to the formation ...
Toskić-Radojčić Marija +4 more
doaj +1 more source
Acta Scientiarum. Health Sciences, 2020 The objective of this study was to evaluate a pH-dependent system of ileocolonic release of active ingredients using the polymer Eudragit® S100. A spouted bed was used in the coating process of soft capsules containing palm oil and of hard capsules ...
Luciana Arantes Soares, Eduardo Crema
doaj +1 more source
Neuropsychopharmacology Reports, 2023 Aim We conducted a 1‐year retrospective mirror‐image study to investigate the effect of aripiprazole once monthly (AOM) on rehospitalization for bipolar disorder.
Junichi Goto +6 more
doaj +1 more source
Lysophosphatidic acid increases the electrophysiological instability of adult rabbit ventricular myocardium by augmenting L-type calcium current. [PDF]
PLoS ONE, 2012 Lysophosphatidic acid (LPA) has diverse actions on the cardiovascular system and is widely reported to modulate multiple ion currents in some cell types. However, little is known about its electrophysiological effects on cardiac myocytes.
Yong Wei +10 more
doaj +1 more source