Results 11 to 20 of about 56,203 (301)

Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve. [PDF]

PLoS ONE, 2012
BACKGROUND: The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti-inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle.
Attila Kristóf, Zoltán Husti, István Koncz, Zsófia Kohajda, Tamás Szél, Viktor Juhász, Péter Biliczki, Norbert Jost, István Baczkó, Julius Gy Papp, András Varró, László Virág   +11 more
doaj   +4 more sources

N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes. [PDF]

PLoS ONE, 2011
BACKGROUND AND OBJECTIVE: The slow delayed rectifier current (I(Ks)) is important for cardiac action potential termination. The underlying channel is composed of Kv7.1 α-subunits and KCNE1 β-subunits.
Zenawit Girmatsion, Peter Biliczki, Ina Takac, Christin Schwerthelm, Stefan H Hohnloser, Joachim R Ehrlich   +5 more
doaj   +3 more sources

Acetylcholine Reduces I_Kr and Prolongs Action Potentials in Human Ventricular Cardiomyocytes

Biomedicines, 2022
Vagal nerve stimulation (VNS) has a meaningful basis as a potentially effective treatment for heart failure with reduced ejection fraction. There is an ongoing VNS randomized study, and four studies are completed.
István Koncz, Arie O. Verkerk, Michele Nicastro, Ronald Wilders, Tamás Árpádffy-Lovas, Tibor Magyar, Noémi Tóth, Norbert Nagy, Micah Madrid, Zexu Lin, Igor R. Efimov   +10 more
doaj   +1 more source

Class I Gap-formation in Highly-viscous Glass-ionomer Restorations: Delayed vs Immediate Polishing [PDF]

, 2008
This in vitro study evaluated the effects of delayed versus immediate polishing to permit maturation of interfacial gap-formation around highly viscous conventional glass-ionomer cement (HV-GIC) in Class I restorations, together with determining the ...
Maruo, Yukinori, Suzuki, Kazuomi, Watts, David C, Nishgawa, Goro, Watts, David C.; id_orcid, Irie, Masao   +5 more
core   +1 more source

Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Ibrutinib and acalabrutinib are Bruton tyrosine kinase inhibitors used in the treatment of B‐cell lymphoproliferative disorders. Ibrutinib is associated with new‐onset atrial fibrillation.
Jari M. Tuomi, Loryn J. Bohne, Tristan W. Dorey, Hailey J. Jansen, Yingjie Liu, Douglas L. Jones, Robert A. Rose   +6 more
doaj   +1 more source

Effect of a delayed-action phenytoin preparation on blood phenytoin concentration [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1972
In a cross-over study in a group of epileptic patients it was shown that replacement of the evening dose of an ordinary phenytoin preparation with the same phenytoin dose in a delayed-action preparation produced no significant change in the next morning's mean blood phenytoin concentration.
F, Bochner, W D, Hooper, J H, Tyrer, M J, Eadie   +3 more
openaire   +2 more sources

Long-acting antipsychotic drugs for the treatment of schizophrenia: use in daily practice from naturalistic observations

BMC Psychiatry, 2012
Background Current guidelines suggest specific criteria for oral or long-acting injectable antipsychotic drugs (LAIs). This review aims to describe the demographic and clinical characteristics of the ideal profile of the patient with schizophrenia ...
Rossi Giuseppe, Frediani Sonia, Rossi Roberta, Rossi Andrea   +3 more
doaj   +1 more source

Diabetes mellitus attenuates the repolarization reserve in mammalian heart [PDF]

, 2007
Objective: In diabetes mellitus several cardiac electrophysiological parameters are known to be affected. In rodent experimental diabetes models changes in these parameters were reported, but no such data are available in other mammalian species ...
Lengyel, Csaba Attila, Papp, Julius Gyula, Biliczki, Péter, Tóth, Miklós, Jost, Norbert, Nánási, Péter Pál, Virág, László, Kocsis, Erzsébet, Varró, András, Bíró, Tamás, Skoumal, Réka, Kecskeméti, Valéria, Magyar, János   +12 more
core   +1 more source

Comparison between immediate and delayed post space preparations: a systematic review and meta-analysis [PDF]

, 2021
Objectives: This systematic review and meta-analysis compared the effects of immediate and delayed post space preparation on apical sealing. Materials and method: Two independent authors conducted a systematic search (PubMed/Medline, Cochrane Library,
Francine Benetti, Alexandre Henrique dos Reis Prado, Ana Cecília Diniz Viana, Lucas Guimarães Abreu, Elen Marise Castro de Oliveira, Isabella Faria da Cunha Peixoto, Juliana Vilela Bastos, Antônio Paulino Ribeiro Sobrinho, Warley Luciano Fonseca Tavares   +8 more
core   +1 more source

Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay [PDF]

, 2008
Introduction: We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy ...
Borelli, Claudia, Fluhr, J. W., Korting, Hans Christian, Schinzel, S., Gassmueller, J., Nietsch, K. H.   +5 more
core   +1 more source