Results 41 to 50 of about 56,203 (301)

Hollow microneedles as a flexible dosing control solution for transdermal drug delivery

Materials Today Bio
Microneedles, small needle-like structures typically less than 1000 μm in length, are effective tools for transporting substances across biological barriers via minimally invasive pathways.
Jongwon Kim, Jaeheon Jeong, Jung Ki Jo, Hongyun So   +3 more
doaj   +1 more source

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]

, 2005
Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Lengyel, Csaba Attila, Varró, András, Takács, János, Bogáts, Gábor, Nagy, Zsolt, Lathrop, David A., Biliczki, Péter, Bitay, Miklós, Jost, Norbert, Virág, László, Papp, Gyula   +10 more
core  

Interferons: the Nature, Mechanisms of Action and Clinical Use of Interferon Preparations [PDF]

, 2016
The lecture deals with the use of interferons in the clinical practice. Attention is paid to the history of the discovery of interferons, mechanism of their action, efficacy of various interferon ...
I.V. Dziublyk
core   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Delayed afterdepolarizations and triggered activity induced in feline Purkinje fibers by alpha-adrenergic stimulation in the presence of elevated calcium levels. [PDF]

, 1984
We studied the ability of alpha-adrenergic stimulation to induce delayed afterdepolarizations and triggered activity in Purkinje fibers from cat hearts in the presence of an elevated Ca++ concentration.
P L Kozlovskis, A L Bassett, R J Myerburg, KIMURA, S, CAMERON, J. S, BASSETT, A. L, MYERBURG, R. J, KOZLOVSKIS, P. L, S Kimura, J S Cameron   +9 more
core   +1 more source

Ironic Medications: A Narrative‐Based Psycho‐Educational Intervention to Explore Patient–Provider Communication in Adolescents With Haematological Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with haematological malignancies face significant emotional and relational challenges, often accompanied by difficulties in communicating their needs within the healthcare context. To address these issues, a narrative‐based psycho‐educational intervention based on the creation and prescription of Ironic Medications was ...
Marta Stoppa, Elena Pagani Bagliacca, Selena Russo, Giulia Rampoldi, Maria Grazia Strepparava, Adriana Cristina Balduzzi, Andrea Biondi, Marco Spinelli   +7 more
wiley   +1 more source

Case Report: Atypical neuroleptic malignant syndrome induced by paliperidone palmitate—diagnostic challenges and clinical considerations

Frontiers in Psychiatry
Poor treatment adherence is common in schizophrenia and constitutes a major risk factor for relapse and clinical instability. Long-acting injectable (LAI) antipsychotics are frequently prescribed to mitigate this risk; however, their use can be ...
Omar El Oumary, Omar El Oumary, Hicham Laaraj, Mina Ouhamou, Khalid Mouhadi, Jalal Doufik, Jalal Doufik, Khadija Akebour, Khadija Akebour, Saliha Hamri, Ismail Rammouz, Ismail Rammouz   +11 more
doaj   +1 more source

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara, George Bogonko, Festus Njuguna, Sandra Langat, Martha Kipngetich, Dennis Njenga, Gertjan Johannes Kaspers, Terry Allen Vik   +7 more
wiley   +1 more source

Complex View on Poisoning with Nerve Agents and Organophosphates

Acta Medica, 2005
OP/nerve agents are still considered as important chemicals acting on living organisms and widely used in human practice. Nerve agents are the most lethal chemical warfare agents.
Jiří Bajgar
doaj   +1 more source

Inpatient Exposure, Confidence, and Knowledge in Pediatric Hematology/Oncology: Evaluating General Pediatric Residents During 2025 ACGME Curriculum Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background General pediatricians often evaluate hematologic and oncologic presentations before subspecialty consultation, yet the 2025 Accreditation Council for Graduate Medical Education (ACGME) pediatric requirements reduce inpatient pediatric hematology/oncology (PHO) time, raising questions about resident readiness.
Colburn Yu, Rohini Jain
wiley   +1 more source