Results 41 to 50 of about 56,045 (301)

Complex View on Poisoning with Nerve Agents and Organophosphates

Acta Medica, 2005
OP/nerve agents are still considered as important chemicals acting on living organisms and widely used in human practice. Nerve agents are the most lethal chemical warfare agents.
Jiří Bajgar
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Comparative analysis of the effectiveness of chondroitin sulfate, hyaluronic acid and arthroscopy at the initial stages of hip osteoarthritis

Bolʹ, Sustavy, Pozvonočnik, 2017
Background. The efficiency of modern drugs that modify the course of the disease is still doubtful, especially, their influence on the long-term effects of hip osteoarthritis.
V.G. Lutsyshyn, A.V. Kalashnikov, O.V. Maiko, V.M. Maiko   +3 more
doaj   +1 more source

Action-effect bindings and ideomotor learning in intention- and stimulus-based actions

, 2012
Herwig A, Waszak F. Action-effect bindings and ideomotor learning in intention- and stimulus-based actions. Frontiers in Psychology. 2012;3: 444.According to ideomotor theory, action-effect associations are crucial for voluntary action control. Recently,
Herwig, Arvid, Waszak, F., Arvid eHerwig, Herwig, Arvid ; https://orcid.org/, Florian Waszak, Waszak, Florian, Arvid Herwig, Herwig, A., Florian eWaszak   +8 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Cytochrome P450 inhibitory action of echinacea preparations differs widely and co-varies with alkylamide content

, 2007
Echinacea preparations are one of the best selling herbal medicinal products with a well established therapeutic use in the prophylaxis of upper respiratory tract infections. Their consumption is increasing, but information about their ability to inhibit
Heinrich, Michael, Kortenkamp, A, Gertsch, J, Modarai, M, Suter, A, Heinrich, M   +5 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The Pharmacokinetics, Dosage, Preparation Forms, and Efficacy of Orally Administered Melatonin for Non-Organic Sleep Disorders in Autism Spectrum Disorder During Childhood and Adolescence: A Systematic Review

Children
Background: To date, it remains unclear which oral doses and preparation forms of melatonin should be recommended for children and adolescents with non-organic sleep disorders and autism spectrum disorder (ASD). We reviewed the current state of knowledge
Ekkehart Paditz, Bertold Renner, Rainer Koch, Barbara M. Schneider, Angelika A. Schlarb, Osman S. Ipsiroglu   +5 more
doaj   +1 more source

Comparison of pharmacological activity of hawthorn fruits preparations [PDF]

, 2020
Objectives a comparative study of antidepressant activity and diuretic action of water and water-alcohol preparations of the fruits ofCrataegus sanguinea Pall.andCrataegus submollis Sarg.
Elena V. Avdeeva, Alina V. Zhdanova, Vladimir A. Kurkin, Ilnur Kh. Shaikhutdinov, Viktoriya V. Stenyaeva, Elena N. Zaitceva   +5 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source