Results 61 to 70 of about 56,203 (301)

In vitro comparison of the complement-scavenging capacity of different intravenous immunoglobulin preparations [PDF]

, 2009
BACKGROUND AND OBJECTIVES: Complement inhibition is considered important in the mechanism of action of intravenous immunoglobulin (IVIG) in a number of inflammatory and autoimmune disorders.
Matozan, K, K. Matozan, S. Miescher, M. Spycher, R. Rieben, L. Hoefferer, R. Zehnder, Minnig, K, Miescher, S, Hoefferer, L, Spycher, M, Rieben, R, K. Minnig, Zehnder, R   +13 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Synergistic action of enzyme preparations towards recalcitrant corn silage polysaccharides [PDF]

, 2014
Corn silage, its water unextractable solids (WUS) and enzyme recalcitrant solids (ErCS) and an industrial corn silage-based anaerobic fermentation residue (AFR) represent corn substrates with different levels of recalcitrance.
Schols, H.A., Neumüller, K.G., Streekstra, H., Gruppen, H.   +3 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue

Scientific Reports, 2017
Since current experimental models of Atrial Fibrillation (AF) have significant limitations, we used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF for pharmacologic testing.
Zachary Laksman, Marianne Wauchop, Eric Lin, Stephanie Protze, Jeehoon Lee, Wallace Yang, Farzad Izaddoustdar, Sanam Shafaattalab, Lior Gepstein, Glen F. Tibbits, Gordon Keller, Peter H. Backx   +11 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways

Frontiers in Pharmacology, 2017
Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Valentina Caputi, Ilaria Marsilio, Silvia Cerantola, Silvia Cerantola, Mona Roozfarakh, Isabella Lante, Francesca Galuppini, Massimo Rugge, Eleonora Napoli, Cecilia Giulivi, Cecilia Giulivi, Genny Orso, Maria Cecilia Giron   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of diclofenac on action potentials in canine right ventricular muscle preparations and in Purkinje fibers. [PDF]

, 2013
Representative superimposed records (top) demonstrating the effect of 20 µM diclofenac on action potential configuration at 1 s stimulation cycle length (A, right ventricular muscle; B, Purkinje fiber).
Norbert Jost (291188), László Virág (219742), Péter Biliczki (291187), András Varró (219743), Viktor Juhász (291185), István Baczkó (291190), István Koncz (291182), Julius Gy Papp (291192), Zoltán Husti (291181), Attila Kristóf (291180), Zsófia Kohajda (291183), Tamás Szél (291184)   +11 more
core   +1 more source