Results 81 to 90 of about 56,203 (301)

Post‐marketing surveillance of quetiapine fumarate extended‐release tablets in patients with bipolar depression

Neuropsychopharmacology Reports
Aim This study aimed to verify the real‐world efficacy and safety of quetiapine fumarate extended‐release tablets (Bipresso® 50 mg and 150 mg; marketing authorization holder is KYOWA Pharmaceutical Industry Co., Ltd., Osaka, Japan) in patients with ...
Taro Kishi, Nakao Iwata, Hiroyuki Irie, Masaru Aikawa   +3 more
doaj   +1 more source

Larvicidal, Repellent and Irritant Potential of the Seed-derived Essential oil of Apium graveolens against Dengue Vector, Aedes aegypti L. (Diptera: Culicidae)

Frontiers in Public Health, 2014
Aedes aegypti L., the primary carrier for viruses causing dengue, chikungunya and yellow fever is widespread over large areas of the tropics and subtropics.
Sarita eKumar, Monika eMishra, Naim eWahab, Radhika eWarikoo   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Preparations for the 20 Year Review of the Barbados Programme of Action for Small Island Developing States (BPoA) and the 10 Year Review of the Mauritius Strategy for Implementation of the Programme of Action for Small Island Developing States (MSI) [PDF]

, 2013
Preparations for the 20 Year Review of the Barbados Programme of Action for Small Island Developing States (BPoA) and the 10 Year Review of the Mauritius Strategy for Implementation of the Programme of Action for Small Island Developing States (MSI ...

core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Evidences of the ultrarapid delayed rectifier potassium current (IKur) on pacemaker activity in sinoatrial and atrioventricular nodes of Rat

Iranian South Medical Journal, 2008
Background: Sinoatrial node (SAN) is the primary pacemaker of the heart. If the SAN activity fails in any way, then the atrioventricular node (AVN) immediately starts to regulate the activities of the heart.
Mohammad reza Nikmaram, Joseph Yanni
doaj  

THE SITES OF ACTION OF 5-HYDROXYTRYPTAMINE IN NERVE-MUSCLE PREPARATIONS FROM THE GUINEA-PIG SMALL INTESTINE AND COLON [PDF]

, 1979
THE SITES OF ACTION OF 5-HYDROXYTRYPTAMINE IN NERVE-MUSCLE PREPARATIONS FROM THE GUINEA-PIG SMALL INTESTINE AND ...
M COSTA (19466260), John Furness (13070439)   +1 more
core  

Enhancement of triggered activity in ischemic purkinje fibers by ouabain: A mechanism of increased susceptibility to digitalis toxicity in myocardial infarction [PDF]

, 1985
Enhanced susceptibility to toxic arrhythmias by digitalis administration has been reported in clinical and experimental myocardial infarction. To investigate the mechanism responsible for this phenomenon, the effects of superfusion with normal Tyrode's ...
Hariman, Robert J., Zeiler, Robert H., El-Sherif, Nabil, Gough, William B.   +3 more
core   +1 more source