Results 51 to 60 of about 56,045 (301)

Intratumoral sustained release of resiquimod with ablative fractional laser induces efficacy in a cutaneous squamous cell carcinoma mouse model

Frontiers in Immunology
IntroductionThe Toll-like receptor (TLR) 7/8 agonist resiquimod has shown promise for precancerous lesions of cutaneous squamous cell carcinoma (cSCC) but remains unexplored as a treatment for cSCC.
Martin Wiinberg, Fredrik Melander, Catharina M. Lerche, Catharina M. Lerche, Thomas L. Andresen, Uffe H. Olesen, Merete Haedersdal   +6 more
doaj   +1 more source

Antiarrhythmic Effects of Simvastatin in Canine Pulmonary Vein Sleeve Preparations

, 2011
ObjectivesThe purpose of this study was to determine the electrophysiologic effects of simvastatin in canine pulmonary vein (PV) sleeve preparations.BackgroundEctopic activity arising from the PV plays a prominent role in the development of atrial ...
Zygmunt, Andrew C., Antzelevitch, Charles, Andrew C. Zygmunt, Sicouri, Serge, Cordeiro, Jonathan M., Jonathan M. Cordeiro, Charles Antzelevitch, Gianetti, Brittany, Brittany Gianetti, Serge Sicouri   +9 more
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Effects of Exposure to Physical Factors on Homeopathic Preparations as Determined by Ultraviolet Light Spectroscopy [PDF]

, 2010
Clinical trials have reported statistically significant and clinically relevant effects of homeopathic preparations. We applied ultraviolet (UV) spectroscopy to investigate the physical properties of homeopathic preparations and to contribute to an ...
Stephan Baumgartner, Ursula Wolf, Barbara Marschollek, Peter Heusser, Mathias Nelle, Wolf, Martin, Heusser, Peter, Wolf, Ursula, Martin Wolf, Baumgartner, Stephan, Nelle, Mathias, Marschollek, Barbara   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The study of stimulation action of enzymes preparations on the plant objects

, 2005
This article is devoted to stimulation action of lytic enzyme preparations. The treatment of the plant seeds by these preparations increased their germination and had positive effect on plant ...
Kilochok, Т. P., Vinnikov, A. I., I. V. Zhernosekova, N. P. Chernogor, Chernogor, N. P., Zhernosekova, I. V., A. I. Vinnikov, Tymchuk, А. А., А. А. Tymchuk, Т. P. Kilochok   +9 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue

Scientific Reports, 2017
Since current experimental models of Atrial Fibrillation (AF) have significant limitations, we used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF for pharmacologic testing.
Zachary Laksman, Marianne Wauchop, Eric Lin, Stephanie Protze, Jeehoon Lee, Wallace Yang, Farzad Izaddoustdar, Sanam Shafaattalab, Lior Gepstein, Glen F. Tibbits, Gordon Keller, Peter H. Backx   +11 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

UMS_Community Guidance_UMS Action Steps for Coronavirus Preparations

, 2020
UMS Action Steps for Coronavirus Preparations, as of February 27, 2020, from the webpages of the University of Maine ...
University of Maine System
core