Results 71 to 80 of about 466,787 (269)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Periodic asymmetric field enhances electrofusion of nanoscale lipid systems

Nature Communications
Electrofusion is a widely used technique for inducing membrane merging in biological systems, with applications ranging from hybrid lipid architectures to therapeutic delivery.
Honghui Wu, Wen-Che Liu, Xuanyu Wu, Zhuoting Li, Jialu Zhang, Jiawen Wang, Qing Zhu, Jinsong Zhang, Kairu Dong, Ruyi Lin, Huihui Hu, Junjie Zeng, Jiaying Wu, Kan Li, Kewang Nan, Tianyuan Zhang, Jianqing Gao   +16 more
doaj   +1 more source

Synthesis of HA-SS-MP: A Prodrug With High Specificity for Cancer Cells

Natural Product Communications, 2020
Thiolated hyaluronic acid was synthesized, and a quantification method was established to determine the content of the thiol group. Three thiol compounds, 2-nitro-5-mercapto-benzoic acid (TNB), 2- mercaptonicotinic acid (2-MNA), and mercaptopyridine (MPD)
Bo Tao, Zong-ning Yin
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Targeted nanomedicines for the treatment of inflammatory disorders and cancer [PDF]

, 2012
The therapeutic value of various targeted nanomedicines was evaluated in several inflammatory disorders, including cancer, while exploring which nanocarrier may be most suitable for a specific therapeutic application. First, an overview of drug targeting
Pharmaceutics, Dep Farmaceutische wetenschappen, Crielaard, B.J., Sub Drug targeting, Advanced drug delivery systems/drug targeting   +4 more
core  

Drug delivery systems for local anesthetics [PDF]

, 2010
Although technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued.
Tofoli, Giovana R., Fraceto, Leonardo F. [UNESP], de Paula, Eneida, De Araújo, Daniele R., Franz-Montan, Michelle, Cereda, Cíntia M.S.   +5 more
core   +1 more source

Highly pathogenic coronaviruses: thrusting vaccine development in the spotlight

Acta Pharmaceutica Sinica B, 2020
Coronaviruses (CoVs) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS).
Chunting He, Ming Qin, Xun Sun
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Drug delivery with living cells [PDF]

, 2016
The field of drug delivery has grown tremendously in the past few decades by developing a wide range of advanced drug delivery systems. An interesting category is cell-based drug delivery, which includes encapsulation of drugs inside cells or attached to
Fliervoet, Lies A L, Mastrobattista, Enrico   +1 more
core  

Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery [PDF]

, 2014
Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics.
Conway, Barbara R, Kakadia, Pratibha G., Conway, Barbara, Kakadia, Partibha   +3 more
core   +1 more source