Results 21 to 30 of about 11,877,029 (313)

Effect of XlogP and hansen solubility parameters on the prediction of small molecule modified docetaxel, doxorubicin and irinotecan conjugates forming stable nanoparticles

Drug Delivery, 2021
Small molecule-chemotherapeutic drug conjugate nanoparticles (SMCDC NPs) has a great advantage in improving drug loading. However, the factors which influence these conjugates forming stable nanoparticles (NPs) are currently unclear.
Mei-Qi Xu, Ting Zhong, Xin Yao, Zhuo-Yue Li, Hui Li, Jing-Ru Wang, Zhen-Han Feng, Xuan Zhang   +7 more
doaj   +1 more source

Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer

Acta Pharmaceutica Sinica B, 2019
Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin (DOX) and Toll-like receptor 7 agonist imiquimod (IMQ) in low molecular weight ...
Jiaojie Wei, Yang Long, Rong Guo, Xinlei Liu, Xian Tang, Jingdong Rao, Sheng Yin, Zhirong Zhang, Man Li, Qin He   +9 more
doaj   +1 more source

Polymeric Drug Delivery Systems by Additive Manufacturing [PDF]

, 2021
Additive manufacturing (AM) is gaining interests in drug delivery applications, offering innovative opportunities for the design and development of systems with complex geometry and programmed controlled release profile.
Borandeh, Sedigheh, Teotia, Arun, Seppälä, Jukka, van Bochove, Bas   +3 more
core   +1 more source

Modular assembly of indole alkaloids enabled by multicomponent reaction

Nature Communications, 2023
Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in pharmaceuticals. Although methods for the synthesis of indole alkaloids are constantly explored, the direct single-step synthesis of these chemical entities ...
Jiaming Li, Zhencheng Lai, Weiwei Zhang, Linwei Zeng, Sunliang Cui   +4 more
doaj   +1 more source

Discovery, Validation, and Target Prediction of Antibacterial and Antidiabetic Components of Archidendron clypearia Based on a Combination of Multiple Analytical Methods

Molecules, 2023
Archidendron clypearia (A. clypearia), a Fabaceae family member, is widely used as an anti-inflammatory herbal medicine; however, its antibacterial and antidiabetic properties have not been extensively investigated.
Wenduo Ji, Lixia Gu, Xuezhe Zou, Zhichao Li, Xiaohong Xu, Jialin Wu, Shu Zhang, Hong Deng   +7 more
doaj   +1 more source

Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS

Acta Pharmaceutica Sinica B, 2020
Chemotherapy agents have been widely used for cancer treatment, while the insolubility, instability and toxicity seriously restrict their efficacy. Thus, prodrug strategy was devised.
Rong Guo, Yang Long, Zhengze Lu, Miao Deng, Penghui He, Man Li, Qin He   +6 more
doaj   +1 more source

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

Drug Delivery, 2021
Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs), act as immunogenic cell death (ICD)
Xiao-Chuan Duan, Li-Yuan Peng, Xin Yao, Mei-Qi Xu, Hui Li, Shuai-Qiang Zhang, Zhuo-Yue Li, Jing-Ru Wang, Zhen-Han Feng, Guang-Xue Wang, Ai Liao, Ying Chen, Xuan Zhang   +12 more
doaj   +1 more source

Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode

Drug Delivery, 2023
Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order to improve drug efficacy. We have previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the
Huamei Li, Fuda Dai, Hanyu Liu, Qi Tao, Jie Hu, Yangrong Zhang, Zhenping Xiao, Ilva D. Rupenthal, Huihui Li, Fan Yang, Wei Li, Huaqing Lin, Dongzhi Hou   +12 more
doaj   +1 more source

Polymers for Drug Delivery Systems [PDF]

Annual Review of Chemical and Biomolecular Engineering, 2010
Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs.
William B, Liechty, David R, Kryscio, Brandon V, Slaughter, Nicholas A, Peppas   +3 more
openaire   +2 more sources

Gastroretentive microparticles for drug delivery applications [PDF]

, 2011
Many strategies have been proposed to explore the possibility of exploiting gastroretention for drug delivery. Such systems would be useful for local delivery, for drugs that are poorly soluble at higher pH or primarily absorbed from the proximal small ...
Conway, Barbara R, Barbara R. Conway, Adeola Adebisi, Adebisi, Adeola, Conway, Barbara R., Adebisi, Adeola O.   +5 more
core   +1 more source