Results 11 to 20 of about 464,584 (319)

Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery [PDF]

, 2020
Tissue barriers limit drug delivery in the eye. Therefore, retinal diseases are treated with intravitreal injections. Delivery systems with reduced dosing frequency and/or cellular drug delivery properties are needed.
Sadeghi, Amir, Sarkhel, Sanjay, Bahrpeyma, Sina, Toropainen, Elisa, Auriola, Seppo, Bhattacharya, Madhushree, Hagström, Marja, Urtti, Arto   +7 more
core   +1 more source

Discovery, Validation, and Target Prediction of Antibacterial and Antidiabetic Components of Archidendron clypearia Based on a Combination of Multiple Analytical Methods

Molecules, 2023
Archidendron clypearia (A. clypearia), a Fabaceae family member, is widely used as an anti-inflammatory herbal medicine; however, its antibacterial and antidiabetic properties have not been extensively investigated.
Wenduo Ji, Lixia Gu, Xuezhe Zou, Zhichao Li, Xiaohong Xu, Jialin Wu, Shu Zhang, Hong Deng   +7 more
doaj   +1 more source

Gastroretentive microparticles for drug delivery applications [PDF]

, 2011
Many strategies have been proposed to explore the possibility of exploiting gastroretention for drug delivery. Such systems would be useful for local delivery, for drugs that are poorly soluble at higher pH or primarily absorbed from the proximal small ...
Conway, Barbara R, Barbara R. Conway, Adeola Adebisi, Adebisi, Adeola, Conway, Barbara R., Adebisi, Adeola O.   +5 more
core   +1 more source

Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS

Acta Pharmaceutica Sinica B, 2020
Chemotherapy agents have been widely used for cancer treatment, while the insolubility, instability and toxicity seriously restrict their efficacy. Thus, prodrug strategy was devised.
Rong Guo, Yang Long, Zhengze Lu, Miao Deng, Penghui He, Man Li, Qin He   +6 more
doaj   +1 more source

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

Drug Delivery, 2021
Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs), act as immunogenic cell death (ICD)
Xiao-Chuan Duan, Li-Yuan Peng, Xin Yao, Mei-Qi Xu, Hui Li, Shuai-Qiang Zhang, Zhuo-Yue Li, Jing-Ru Wang, Zhen-Han Feng, Guang-Xue Wang, Ai Liao, Ying Chen, Xuan Zhang   +12 more
doaj   +1 more source

Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode

Drug Delivery, 2023
Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order to improve drug efficacy. We have previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the
Huamei Li, Fuda Dai, Hanyu Liu, Qi Tao, Jie Hu, Yangrong Zhang, Zhenping Xiao, Ilva D. Rupenthal, Huihui Li, Fan Yang, Wei Li, Huaqing Lin, Dongzhi Hou   +12 more
doaj   +1 more source

Supramolecular nanomedicines based on host–guest interactions of cyclodextrins

Exploration, 2023
In the biomedical and pharmaceutical fields, cyclodextrin (CD) is undoubtedly one of the most frequently used macrocyclic compounds as the host molecule because it has good biocompatibility and can increase the solubility, bioavailability, and stability ...
Fan Tong, Yang Zhou, Yanyan Xu, Yuxiu Chen, Natalia Yudintceva, Maxim Shevtsov, Huile Gao   +6 more
doaj   +1 more source

Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

Nature Communications, 2017
Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.
Ling Guo, Shi Luo, Zhengwu Du, Meiling Zhou, Peiwen Li, Yao Fu, Xun Sun, Yuan Huang, Zhirong Zhang   +8 more
doaj   +1 more source

Nanomaterial-Based Drug Delivery Systems for Ischemic Stroke

, 2023
Ischemic stroke is a leading cause of death and disability in the world. At present, reperfusion therapy and neuroprotective therapy, as guidelines for identifying effective and adjuvant treatment methods, are limited by treatment time windows, drug ...
Haimei Zhou, Dongdong Qin, Zhengxiu Tang, Yang Zhou, Rong Chen, Chengting Jiang, Mengjia Yang, Hongling Shi   +7 more
core   +1 more source

Synthesis and evaluation of cationic polymeric micelles as carriers of lumbrokinase for targeted thrombolysis

Asian Journal of Pharmaceutical Sciences, 2019
To achieve targeted thrombolysis, a targeted delivery system of lumbrokinase (LK) was constructed using RGDfk-conjugated hybrid micelles. Based on the specific affinity of RGDfk to glycoprotein complex of GPⅡb/Ⅲa expressed on the surface of membrane of ...
Yang Pan, Xiahui Wang, Zongning Yin
doaj   +1 more source