Results 31 to 40 of about 1,036,500 (313)

A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges [PDF]

, 2015
Dry eye syndrome (DES) or keratoconjunctivitis sicca (KCS) is a common disorder of the tear film caused by decreased tear production or increased evaporation and manifests with a wide variety of signs and symptoms.
Askarkar, S, Momin, M, Nighojkar, P, Phadatare, S, Singh, Kamalinder   +4 more
core   +2 more sources

Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode

Drug Delivery, 2023
Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order to improve drug efficacy. We have previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the
Huamei Li, Fuda Dai, Hanyu Liu, Qi Tao, Jie Hu, Yangrong Zhang, Zhenping Xiao, Ilva D. Rupenthal, Huihui Li, Fan Yang, Wei Li, Huaqing Lin, Dongzhi Hou   +12 more
doaj   +1 more source

The use of heat and chemical penetration enhancers to increase the follicular delivery of erythromycin to the skin [PDF]

, 2019
Copyright © 2019. Published by Elsevier B.V.The effect of heat on the follicular absorption of drugs into the skin has not previously been investigated.
Akomeah, Alberti, Baden, Butcher, Cada, Coldman, Edwards, F. Caserta, FDA, Feldmann, Goh, Higuchi, ICH, Q2(R1), Kim, Kligman, Liu, M.B. Brown, McAuley, McAuley, Minson, Motwani, Motwani, OECD, Oliveira, Otberg, Park, Piazza, Pierard, Rancan, Saar, Santos, Sato, Shergill, Szabo, Teichmann, Toll, Twist, W.J. McAuley, Wood, Wood, Wood, Yarnitsky, Zhang   +42 more
core   +2 more sources

Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS

Acta Pharmaceutica Sinica B, 2020
Chemotherapy agents have been widely used for cancer treatment, while the insolubility, instability and toxicity seriously restrict their efficacy. Thus, prodrug strategy was devised.
Rong Guo, Yang Long, Zhengze Lu, Miao Deng, Penghui He, Man Li, Qin He   +6 more
doaj   +1 more source

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

Drug Delivery, 2021
Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs), act as immunogenic cell death (ICD)
Xiao-Chuan Duan, Li-Yuan Peng, Xin Yao, Mei-Qi Xu, Hui Li, Shuai-Qiang Zhang, Zhuo-Yue Li, Jing-Ru Wang, Zhen-Han Feng, Guang-Xue Wang, Ai Liao, Ying Chen, Xuan Zhang   +12 more
doaj   +1 more source

Supramolecular nanomedicines based on host–guest interactions of cyclodextrins

Exploration, 2023
In the biomedical and pharmaceutical fields, cyclodextrin (CD) is undoubtedly one of the most frequently used macrocyclic compounds as the host molecule because it has good biocompatibility and can increase the solubility, bioavailability, and stability ...
Fan Tong, Yang Zhou, Yanyan Xu, Yuxiu Chen, Natalia Yudintceva, Maxim Shevtsov, Huile Gao   +6 more
doaj   +1 more source

Nanoparticle drug delivery systems for inner ear therapy: An overview [PDF]

, 2017
open7noembargoed_20180701Valente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini, AlessandroValente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini,
Astolfi, Laura, Chicca, Milvia, DANTI, SERENA, Franceschini, Valeria, Martini, Alessandro, Simoni, Edi, Valente, Filippo   +6 more
core   +2 more sources

Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

Nature Communications, 2017
Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.
Ling Guo, Shi Luo, Zhengwu Du, Meiling Zhou, Peiwen Li, Yao Fu, Xun Sun, Yuan Huang, Zhirong Zhang   +8 more
doaj   +1 more source

Hydrophilic Matrices for Oral Control Drug Delivery [PDF]

, 2015
Oral controlled drug delivery has gathered tremendous attention over the years due to its many advantages over conventional dosage forms. Polymer-based matrices have become an integral part of the pharmaceutical industry. Hydrophilic matrices are capable
Conway, Barbara R, Ghori, Muhammad U.
core   +1 more source

Intracochlear drug delivery systems [PDF]

Expert Opinion on Drug Delivery, 2011
Advances in molecular biology and in the basic understanding of the mechanisms associated with sensorineural hearing loss and other diseases of the inner ear are paving the way towards new approaches for treatments for millions of patients. However, the cochlea is a particularly challenging target for drug therapy, and new technologies will be required
openaire   +2 more sources