Results 291 to 300 of about 1,703,096 (348)
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Targeted Lipid Nanoparticles for Antisense Oligonucleotide Delivery
Current Pharmaceutical Biotechnology, 2014Antisense oligonucleotides (AS-ODNs) are short, single-stranded DNA molecules designed to bind specifically to a target messenger RNA (mRNA) and down-regulate gene expression. Despite being a promising class of therapeutics for a variety of diseases, they face major hurdles limiting their clinical application, including low intracellular delivery and ...
Raquel, Petrilli +4 more
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Delivery of antisense oligonucleotides to neuroblastoma cells
NeuroReport, 2000pH-Sensitive liposomes composed of dioleoylphosphatidylethanolamine and cholesterol hemisuccinate (3:2 mol/mol) were applied in delivery of antisense oligodeoxynucleotides (asODN) into NG 108-15 neuroblastoma and glioma cells. Fluorescently labelled asODN were entrapped in liposomes by a modified freeze-thawing method (20% encapsulation efficiency ...
N, Skalko-Basnet, M, Tohda, H, Watanabe
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Novel non-endocytic delivery of antisense oligonucleotides
Advanced Drug Delivery Reviews, 2000Antisense oligonucleotides (ONs) have several properties that make them attractive as therapeutic agents. Hybridization of antisense ONs to their complementary nucleic acid sequences by Watson-Crick base pairing is a highly selective and efficient process.
S, Dokka, Y, Rojanasakul
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Blended Block Polycation Micelles Enhance Antisense Oligonucleotide Delivery
Bioconjugate Chemistry, 2023Nucleic acid-based medicines and vaccines are becoming an important part of our therapeutic toolbox. One key genetic medicine is antisense oligonucleotides (ASOs), which are short single-stranded nucleic acids that downregulate protein production by binding to mRNA. However, ASOs cannot enter the cell without a delivery vehicle.
Mckenna G. Hanson +4 more
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ACS Applied Materials and Interfaces, 2019
Drug resistance is a major obstacle to the efficient therapy of drug-resistant cancer. To overcome this problem, we constructed a multifunctional DNA origami-based nanocarrier for co-delivery of chemotherapeutic drug (Dox) and two different antisense ...
Qingshan Pan +9 more
semanticscholar +1 more source
Drug resistance is a major obstacle to the efficient therapy of drug-resistant cancer. To overcome this problem, we constructed a multifunctional DNA origami-based nanocarrier for co-delivery of chemotherapeutic drug (Dox) and two different antisense ...
Qingshan Pan +9 more
semanticscholar +1 more source
Targeted delivery of antisense oligonucleotides in cancer
Journal of Controlled Release, 2001Formulations of antisense oligonucleotides (asODNs) against c-myb or c-myc protooncogenes have been prepared by a new technique that sequesters cationic lipid in the interior of a lipid particle. This technique results in high loading efficiency for the asODNs, small particle size and good stability.
F, Pastorino +3 more
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Antisense Technology: Selection and Delivery of Optimally Acting Antisense Oligonucleotides
Journal of Drug Targeting, 1998AbstractAntisense technology has increasingly become a reality. It's objective is simple: to inhibit gene expression in a highly sequence-specific and selective manner. The technology has come to encompass three distinct strategies: antigene and antisense oligonucleotides (ODNs) and ribozymes.
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Pharmaceutical Research, 1999
This review critically examines current understanding of the kinetics and biodistribution of antisense oligonucleotides, both at the cellular level and at the level of the intact organism. The pharmacodynamic relationships between biodistribution and the ultimate biological effects of antisense agents are considered.
R L, Juliano +4 more
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This review critically examines current understanding of the kinetics and biodistribution of antisense oligonucleotides, both at the cellular level and at the level of the intact organism. The pharmacodynamic relationships between biodistribution and the ultimate biological effects of antisense agents are considered.
R L, Juliano +4 more
openaire +2 more sources
Angewandte Chemie, 2019
The development of efficient gene delivery vectors has faced two major challenges, namely endo- and lysosomal escape and intracellular release. To address these problems, we developed an oligonucleotide (ON)-template-assisted polymerization approach to ...
Jie Zhou +7 more
semanticscholar +1 more source
The development of efficient gene delivery vectors has faced two major challenges, namely endo- and lysosomal escape and intracellular release. To address these problems, we developed an oligonucleotide (ON)-template-assisted polymerization approach to ...
Jie Zhou +7 more
semanticscholar +1 more source
Nano letters (Print), 2018
One of the biggest obstacles for the use of antisense oligonucleotides as antibacterial therapeutics is their limited uptake by bacterial cells without a suitable carrier, especially in multi-drug-resistant bacteria with a drug efflux mechanism. Existing
Yuxin Zhang +12 more
semanticscholar +1 more source
One of the biggest obstacles for the use of antisense oligonucleotides as antibacterial therapeutics is their limited uptake by bacterial cells without a suitable carrier, especially in multi-drug-resistant bacteria with a drug efflux mechanism. Existing
Yuxin Zhang +12 more
semanticscholar +1 more source