Results 211 to 220 of about 109,213 (308)

Zebrafish models of developmental epileptic encephalopathy accurately reflect clinical electrographic biomarkers

Epilepsia, EarlyView.
Abstract Objective Developmental epileptic encephalopathies (DEEs) are epilepsy conditions characterized by significant severity and treatment challenges. Spectral components of the encephalogram (EEG) may provide a valuable biomarker of epileptic severity.
Paige Whyte‐Fagundes, Joseane Righes Marafiga, Bingyao Zhu, Scott C. Baraban   +3 more
wiley   +1 more source

Glycogen for Smyd3-antisense oligonucleotide delivery and enhanced liver cancer gene therapy. [PDF]

RSC Adv
Bai N, Huang Y, Shen J, Peng Y, Zhang H, Hou D.   +5 more
europepmc   +1 more source

Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2) [PDF]

, 2018
et al,, Picus, Joel
core   +1 more source

Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, EarlyView.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source

Separation of PS diastereomers in GalNAc-conjugated siRNA-a comparative study of chromatographic and ion mobility mass spectrometry approaches. [PDF]

Anal Bioanal Chem
Bill MK, Graglia M, Riley JA, Zugaj M, Demtschenko N, Fox J, Bethge L, Smink JJ, Manz C.   +8 more
europepmc   +1 more source

Algorithms in Allergy: Hereditary Angioedema

Allergy, EarlyView.
Konrad Bork, Markus Magerl, Emel Aygören‐Pürsün, Henriette Farkas   +3 more
wiley   +1 more source

Zebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog

The FEBS Journal, EarlyView.
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola, Deianira Bellitto, Erfan Asgari, Virginia Bazzurro, Giorgia Casucci, Francesco Piacente, Matteo Bozzo, Davide Ceresa, Costantino Parisi, Cecilia Winata, Simona Candiani, Michela Tonetti   +11 more
wiley   +1 more source

Inhibition of calreticulin by protein nanoparticles carrying antisense oligonucleotides reduce gene expression and infection of <i>Trypanosoma cruzi</i> trypomastigotes on mammalian cells. [PDF]

Nanomedicine (Lond)
Prestegui-Martel B, Martínez I, Cárdenas-Guerra RE, Cortés-Coss AK, Del Toro-Ríos X, Hernández-Garcia A, Espinoza B.   +6 more
europepmc   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source