Results 1 to 10 of about 171,175 (241)

ASOG: AntiSense Oligonucleotide Generator [PDF]

Computational and Structural Biotechnology Journal
Antisense oligonucleotides (ASOs) are used in both fundamental research and clinical applications to modulate gene expression by targeting the RNA transcript of specific genes.
Jonah Kimi, Patricia Korczak, Brune Vialet, Eric Roubin, Philippe Barthélémy, Sébastien Campagne, Florian Malard   +6 more
doaj   +2 more sources

Antisense Oligonucleotide-Based Therapy of Viral Infections

Pharmaceutics, 2021
Nucleic acid-based therapeutics have demonstrated their efficacy in the treatment of various diseases and vaccine development. Antisense oligonucleotide (ASO) technology exploits a single-strand short oligonucleotide to either cause target RNA ...
Woan-Yuh Tarn, Li-Min Huang
exaly   +3 more sources

Accurately modeling RNase H-mediated antisense oligonucleotide efficacy [PDF]

Molecular Therapy: Nucleic Acids
Antisense oligonucleotides (ASOs) are a powerful class of drugs with the potential to treat a wide range of human diseases. However, the prediction of ASO efficacy remains challenging, as large-scale and costly experimental screens are typically required
Barney Hill, Maisie R. Jaques, Remya R. Nair, Nicola Whiffin, Matthew J.A. Wood, Stephan J. Sanders, Peter L. Oliver, Alyssa C. Hill, Carlo Rinaldi   +8 more
doaj   +2 more sources

An Investigation into the Potential of Targeting Escherichia coli rne mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy

Molecules, 2021
The increase in antibacterial resistance is a serious challenge for both the health and defence sectors and there is a need for both novel antibacterial targets and antibacterial strategies.
Layla R. Goddard, Charlotte E. Mardle, Hassan Gneid, Ciara G. Ball, Darren M. Gowers, Helen S. Atkins, Louise E. Butt, Jonathan K. Watts, Helen A. Vincent, Anastasia J. Callaghan   +9 more
doaj   +1 more source

A perspective on oligonucleotide therapy: Approaches to patient customization

Frontiers in Pharmacology, 2022
It is estimated that the human genome encodes 15% of proteins that are considered to be disease-modifying. Only 2% of these proteins possess a druggable site that the approved clinical candidates target. Due to this disparity, there is an immense need to
Shikha Thakur, Apurba Sinhari, Priti Jain, Hemant R. Jadhav   +3 more
doaj   +1 more source

In-silico study of antisense oligonucleotide antibiotics [PDF]

PeerJ, 2023
Background The rapid emergence of antibiotic-resistant bacteria directly contributes to a wave of untreatable infections. The lack of new drug development is an important driver of this crisis.
Erica S. Chen, Eric S. Ho
doaj   +2 more sources

Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD

Molecules, 2020
The hexanucleotide expansion GGGGCC located in C9orf72 gene represents the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD).
Tim Božič, Matja Zalar, Boris Rogelj, Janez Plavec, Primož Šket   +4 more
doaj   +1 more source

RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications. [PDF]

PLoS ONE, 2015
The inhibitory potency of an antisense oligonucleotide depends critically on its design and the accessibility of its target site. Here, we used an RNA interference-guided approach to select antisense oligonucleotide target sites in the coding region of ...
Margit Mutso, Andrei Nikonov, Arno Pihlak, Eva Žusinaite, Liane Viru, Anastasia Selyutina, Tõnu Reintamm, Merike Kelve, Mart Saarma, Mati Karelson, Andres Merits   +10 more
doaj   +1 more source

History of Research on Antisense Oligonucleotide Analogs

Substantia, 2021
In the search for novel therapeutics, antisense oligonucleotide (ASO) analogs have been a major focus of research for over 40 years.  They use the antisense strategy, namely they have a nucleic acid base sequence that is complementary to a portion of a ...
Jack S. Cohen
doaj   +1 more source

Polymerase-endonuclease amplification reaction (PEAR) for large-scale enzymatic production of antisense oligonucleotides. [PDF]

PLoS ONE, 2010
Antisense oligonucleotides targeting microRNAs or their mRNA targets prove to be powerful tools for molecular biology research and may eventually emerge as new therapeutic agents.
Xiaolong Wang, Deming Gou, Shuang-yong Xu   +2 more
doaj   +1 more source