Results 41 to 50 of about 270,275 (243)

Synthesis and anti-HIV activity of thiocholesteryl-coupled phosphodiester antisense oligonucleotides incorporated into immunoliposomes [PDF]

, 1994
Encapsulation of oligonucleotides in antibody-targeted liposomes (immunoliposomes) which bind to target cells permits intracellular delivery of the oligonucleotides.
Zelphati, Olivier, Leserman, Lee, Wagner, Ernst   +2 more
core   +1 more source

Antisense Oligonucleotide Therapy for Calmodulinopathy. [PDF]

Circulation
BACKGROUND: Calmodulinopathies are rare inherited arrhythmia syndromes caused by dominant heterozygous variants in CALM1 , CALM2 , or CALM3 , which each encode the identical CaM (calmodulin) protein. We hypothesized that antisense
Bortolin RH, Nawar F, Park C, Trembley MA, Prondzynski M, Sweat ME, Wang P, Chen J, Lu F, Liou C, Berkson P, Keating EM, Yoshinaga D, Pavlaki N, Samenuk T, Cavazzoni CB, Sage PT, Ma Q, Whitehill RD, Abrams DJ, Carreon CK, Putra J, Alexandrescu S, Guo S, Tsai WC, Rubart M, Kubli DA, Mullick AE, Bezzerides VJ, Pu WT.   +29 more
europepmc   +3 more sources

Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

Nature Communications, 2020
While most monogenic diseases are caused by loss or reduction of protein function, the need for technologies that can selectively increase levels of protein in native tissues remains.
K. Lim, Zhou Han, H. Y. Jeon, Jacob Kach, Enxuan Jing, Sebastien M. Weyn-Vanhentenryck, Mikaela Downs, Anna Corrionero, Raymond Oh, Juergen Scharner, Aditya Venkatesh, Sophina Ji, G. Liau, B. Ticho, H. Nash, I. Aznarez   +15 more
semanticscholar   +1 more source

Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS

Science Translational Medicine, 2017
AZD4785 is a therapeutic antisense oligonucleotide targeting KRAS mRNA with promising preclinical antitumor activity and a favorable safety profile.
S. J. Ross, A. Revenko, Lyndsey Hanson, Rebecca P A Ellston, A. Staniszewska, Nicky Whalley, Sanjay K. Pandey, M. Revill, C. Rooney, Linda K. Buckett, Stephanie K. Klein, K. Hudson, Brett P. Monia, M. Zinda, David C. Blakey, Paul D. Lyne, A. Macleod   +16 more
semanticscholar   +2 more sources

Identification of sequence motifs significantly associated with antisense activity

BMC Bioinformatics, 2007
Background Predicting the suppression activity of antisense oligonucleotide sequences is the main goal of the rational design of nucleic acids. To create an effective predictive model, it is important to know what properties of an oligonucleotide ...
Peek Andrew S, McQuisten Kyle A
doaj   +1 more source

Multi-targeted Antisense Oligonucleotide Delivery by a Framework Nucleic Acid for Inhibiting Biofilm Formation and Virulence

Nano-Micro Letters, 2020
A framework nucleic acid delivery system was developed through self-assembly, which can deliver antisense oligonucleotides against multiple targets in bacterial cells. The ASOs-tFNAs (750 nM) was found to simultaneously inhibit the expression of gtfBCD ,
Yuxin Zhang, Xueping Xie, Wenjuan Ma, Yuxi Zhan, Chenchen Mao, X. Shao, Yunfeng Lin   +6 more
semanticscholar   +1 more source

How late is too late for treatment?

eLife, 2023
Experiments on mice suggest that an approach called antisense oligonucleotide therapy may be able to treat some symptoms of Angelman syndrome, including problems with epilepsy and sleep.
Lawrence T Reiter
doaj   +1 more source

The targeted delivery of anti-metastasis oligonucleotide in breast cancer cells by the nanoliposomes conjugated with RGD ligand

Advances in Cancer Biology - Metastasis
To decrease the ETV4 gene, which is important in metastasis, the nanoliposome containing ETV4 antisense oligonucleotide conjugated with Arginylglycylaspartic acid (RGD) ligand was used in the study.
Farahanaz Kavian Manesh, Ali Jebali, Flora Forouzesh   +2 more
doaj   +1 more source

Possibilities and limitations of antisense oligonucleotide therapies for the treatment of monogenic disorders

Communications Medicine
Antisense oligonucleotides (ASOs) are incredibly versatile molecules that can be designed to specifically target and modify RNA transcripts to slow down or halt rare genetic disease progression.
M. C. Lauffer, W. V. van Roon-Mom, Annemieke Aartsma-Rus   +2 more
semanticscholar   +1 more source

Characterization and Evaluation of NGF Antisense Oligonucleotides: Inhibition of NGF Synthesis in Transfected COS Cells

, 1997
We present a system for the assessment of the inhibiting capacity of antisense oligonucleotides. The aim of this study was to identify an oligonucleotide that can inhibit chicken nerve growth factor (NGF) synthesis.
Sahlén, Anders,, STEFAN CATSICAS, Hallböök, Finn,, ANDERS SAHLÉN, Catsicas, S, FINN HALLBÖÖK   +5 more
core   +2 more sources