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RNA, 2023 RNA therapies evolved as economical and widely applicable individualized treatment solutions. Novel RNA-based therapeutic vaccines (e.g., against SARS-CoV-2 infection) have been proven to be safe and effective, and many of them are approved by the United
Hastings ML, Krainer AR.
europepmc +4 more sources
Assembling the RNA therapeutics toolbox [PDF]
Medical ReviewAbstract From the approval of COVID-19 mRNA vaccines to the 2023 Nobel Prize awarded for nucleoside base modifications, RNA therapeutics have entered the spotlight and are transforming drug development. While the term “RNA therapeutics” has been used in various contexts, this review focuses on treatments that utilize RNA as a component ...
Mona Teng, Housheng Hansen He
exaly +5 more sources
RNA therapeutics in the clinic
Bioengineering & Translational Medicine, 2022 Ribonucleic acid (RNA) therapeutics are being actively researched as a therapeutic modality in preclinical and clinical studies. They have become one of the most ubiquitously known and discussed therapeutics in recent years in part due to the ongoing ...
Sankholkar, Disha +7 more
core +4 more sources
RNA-based therapeutics for neurological diseases [PDF]
RNA Biology, 2022 RNA-based therapeutics have entered the mainstream with seemingly limitless possibilities to treat all categories of neurological disease. Here, common RNA-based drug modalities such as antisense oligonucleotides, small interfering RNAs, RNA aptamers ...
Karen Anthony
exaly +2 more sources
RNA chemistry and therapeutics
Nature Reviews Drug DiscoveryRNA-based therapeutics have made substantial clinical advances, primarily due to the unique chemical and biological profiles of RNA molecules. As evidenced by the approval of various RNA drugs, some initial challenges related to RNA-based therapeutics, including issues associated with large-scale production, effective delivery and immunogenicity ...
Drew Weissman +2 more
exaly +3 more sources
RNA editing: Expanding the potential of RNA therapeutics [PDF]
Molecular Therapy, 2023 RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic. In addition, RNA-targeting drugs have been developed for diseases with significant unmet medical needs through selective mRNA knockdown or modulation of pre-mRNA splicing.
Dhruva Katrekar, Prashant Mali
exaly +4 more sources
RNA therapeutics in cardiovascular medicine. [PDF]
Curr Opin CardiolPurpose of review RNA therapeutics came to global attention when mRNA-based vaccines provided an answer to the SARS-CoV-2 pandemic. The immense significance of this development notwithstanding, it is important to note that almost a decade prior to the pandemic, RNA drugs had made important inroads toward the amelioration of ...
Damase TR, Cooke JP.
europepmc +3 more sources
RNA Therapeutics in Heart Failure. [PDF]
J Cardiovasc Transl ResAbstract RNA-based therapeutics, such as small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs) and messenger RNAs (mRNAs) are promising therapeutics that offer new avenues for targeting molecular pathways underlying heart failure (HF) pathogenesis.
Deiman FE +5 more
europepmc +5 more sources
The potential of RNA therapeutics in dermatology
Annals of the Academy of Medicine, SingaporeRibonucleic acid (RNA) therapeutics hold great potential for the advancement of dermatological treatments due to, among other reasons, the possibility of treating previously undruggable targets, high specificity with minimal side effects, and ability to ...
Yingrou Tan +5 more
core +4 more sources