Results 21 to 30 of about 1,193,020 (266)
Quantification of Antisense Oligonucleotides by Splint Ligation and Quantitative Polymerase Chain Reaction [preprint] [PDF]
, 2021 This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.Reliable detection and quantification of antisense oligonucleotides (ASOs) in experimental and clinical specimens is essential to understand
Watts, Jonathan K +2 more
core +1 more source
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Nature Communications, 2023 Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors show distinct efficacy and safety profiles, likely reflecting variable selectivity ...
Qi Tang +35 more
doaj +1 more source
Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway [PDF]
, 2012 tRNA precursors, which are transcribed by RNA polymerase III, undergo end-maturation, splicing and base modifications. Hypomodified tRNAs, such as tRNAVal(AAC), lacking 7-methylguanosine and 5-methylcytidine modifications, are subject to degradation by a
Boguta, Magdalena +3 more
core +1 more source
Molecular Therapy: Nucleic Acids, 2016 The use of siRNA-based therapies for the treatment of neurodegenerative disease requires efficient, nontoxic distribution to the affected brain parenchyma, notably the striatum and cortex.
Mehran Nikan +9 more
doaj +1 more source
RNA Therapeutics in Heart Failure. [PDF]
J Cardiovasc Transl ResRNA-based therapeutics, such as small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs) and messenger RNAs (mRNAs) are promising therapeutics that offer new avenues for targeting molecular pathways underlying heart failure (HF) pathogenesis ...
Deiman FE +5 more
europepmc +2 more sources
RNA-specific ribonucleotidyl transferases [PDF]
, 2007 RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W. +3 more
core +1 more source
RNAi-Based Degradation of C9ORF72 Variants as a Potential Therapy for ALS
, 2022 Amyotrophic, Lateral Sclerosis (ALS), a progressive and fatal disease, is characterized by loss of neurons specifically in the motor cortex, brainstem, and spinal cord.
Gilbert, James
core +1 more source
Scientific Reports, 2017 Eubacterial ribosomal large-subunit methyltransferase H (RlmH) methylates 23S ribosomal RNA pseudouridine 1915 (Ψ1915), which lies near the ribosomal decoding center.
Cha San Koh +4 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2020 Small interfering RNAs (siRNAs) have potential to silence virtually any disease-causing gene but require chemical modifications for delivery to the tissue and cell of interest.
Socheata Ly +3 more
doaj +1 more source
An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei [PDF]
, 2007 RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs.
Schnaufer, Achim; id_orcid +4 more
core +1 more source