Results 21 to 30 of about 243,477 (250)

Advancements in clinical RNA therapeutics: Present developments and prospective outlooks [PDF]

Cell Reports Medicine
Phei Er Saw
exaly   +2 more sources

Nucleic Acid Therapeutics for Neurological Diseases

, 2020
Oligonucleotide therapeutics are emerging as a promising class of therapeutics in various areas of human health. In the long run, oligonucleotides are likely to become a major class of therapeutics, on par with small molecules and biologics.
Watts, Jonathan K, Khvorova, Anastasia, Brown, Robert H. Jr.   +2 more
core   +1 more source

RNAi-Based Degradation of C9ORF72 Variants as a Potential Therapy for ALS

, 2022
Amyotrophic, Lateral Sclerosis (ALS), a progressive and fatal disease, is characterized by loss of neurons specifically in the motor cortex, brainstem, and spinal cord.
Gilbert, James
core   +1 more source

Quantification of Antisense Oligonucleotides by Splint Ligation and Quantitative Polymerase Chain Reaction [preprint]

, 2021
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.Reliable detection and quantification of antisense oligonucleotides (ASOs) in experimental and clinical specimens is essential to understand
Watts, Jonathan K, Shin, Minwook, Krishnamurthy, Pranathi Meda   +2 more
core   +1 more source

The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans [preprint]

, 2020
Eukaryotic cells regulate 5' triphosphorylated (ppp-) RNAs to promote cellular functions and prevent recognition by antiviral RNA sensors. For example, RNA capping enzymes possess triphosphatase domains that remove the γ phosphates of ppp-RNAs during RNA
Li, Lichao, Moresco, James J., Yates, John R. III, Mello, Craig C., Gu, Weifeng, Dai, Hui, Chaves, Daniel A., Conte, Darryl Jr., Eun Oh, Myung   +8 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

RNA therapeutics in the RNA journal [PDF]

RNA
europepmc   +2 more sources

Flnc: Machine Learning Improves the Identification of Novel Long Noncoding RNAs from Stand-Alone RNA-Seq Data

, 2022
Long noncoding RNAs (lncRNAs) play critical regulatory roles in human development and disease. Although there are over 100,000 samples with available RNA sequencing (RNA-seq) data, many lncRNAs have yet to be annotated.
Kwon, Euijin, Zhou, Chan, Li, Zixiu, Fitzgerald, Katherine A, Zhou, Peng, Weng, Zhiping   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Unlocking the potential of RNA interference as a therapeutic tool [PDF]

, 2009
The existence of an intrinsic biochemical pathway enabling specified regulation of gene expression was unheard of until the final years of the last decade.
Day, Philip JR, Ayers, Duncan, Day, Philip J R; id_orcid   +2 more
core