Insights into the structure and activity of prototype foamy virus RNase H
Retrovirology, 2012 Background RNase H is an endonuclease that hydrolyzes the RNA strand in RNA/DNA hybrids. Retroviral reverse transcriptases harbor a C-terminal RNase H domain whose activity is essential for viral replication.
Leo Berit +4 more
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Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy [PDF]
MoleculesRibonuclease H (RNase H) was identified as an important target for HIV therapy. Currently, no RNase H inhibitors have reached clinical status. Herein, a series of novel thiazolone[3,2-a]pyrimidine-containing RNase H inhibitors were developed, based on ...
Xuan-De Zhu +8 more
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Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors [PDF]
MoleculesTargeting ribonuclease H (RNase H) has emerged as a highly promising strategy for treating HIV-1. In this study, a series of novel 3-hydrazonoindolin-2-one derivatives were designed and synthesized as potential inhibitors of HIV-1 RNase H.
Yiying Zhang +10 more
doaj +2 more sources
Ultrasensitive RNase H activity detection using the transcription-based hybrid probe and CRISPR/cas12a signal amplifier [PDF]
Frontiers in PharmacologyRibonuclease H (RNase H), a critical functional protein in replication and genome stability, is emerging as a crucial therapeutic target for various diseases, including immune disorders.
Sheng Ding +6 more
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N-Hydroxypiridinedione: A Privileged Heterocycle for Targeting the HBV RNase H [PDF]
MoleculesHepatitis B virus (HBV) remains a global health threat. Ribonuclease H (RNase H), part of the virus polymerase protein, cleaves the pgRNA template during viral genome replication.
Dimitrios Moianos +8 more
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Synthesis, biophysical properties, and RNase H activity of 6’-difluoro[4.3.0]bicyclo-DNA [PDF]
Beilstein J Org Chem, 2019 Here we present the synthesis, the biophysical properties, and the RNase H profile of 6’-difluorinated [4.3.0]bicyclo-DNA (6’-diF-bc4,3-DNA). The difluorinated thymidine phosphoramidite building block was synthesized starting from an already known gem ...
Sibylle Frei +5 more
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Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants [PDF]
Viruses, 2020 HIV-1 infection requires life-long treatment and with 2.1 million new infections/year, faces the challenge of an increased rate of transmitted drug-resistant mutations.
Angela Corona +12 more
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Cycling Probe Technology with RNase H Attached to an Oligonucleotide
BioTechniques, 1996 A streptavidin-RNase H gene fusion was constructed by cloning the Thermus thermophilus RNase H coding sequence in the streptavidin expression vector pTSA18F.
F. Bekkaoui +4 more
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An RNase H‐Like gene complements resistance to Bean common mosaic necrosis virus in Phaseolus vulgaris [PDF]
The Plant GenomeBean common mosaic virus and Bean common mosaic necrosis virus (BCMNV) are related positive‐sense RNA potyviruses that limit the production of common bean (Phaseolus vulgaris L.) worldwide.
Alvaro Soler‐Garzón +1 more
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Accurately modeling RNase H-mediated antisense oligonucleotide efficacy [PDF]
Molecular Therapy: Nucleic AcidsAntisense oligonucleotides (ASOs) are a powerful class of drugs with the potential to treat a wide range of human diseases. However, the prediction of ASO efficacy remains challenging, as large-scale and costly experimental screens are typically required
Barney Hill +8 more
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