Results 41 to 50 of about 11,506,565 (250)

Efficient and specific DNA oligonucleotide rRNA probe-based rRNA removal in Talaromyces marneffei

Mycology, 2022
Emerging evidence showed that lncRNAs play important roles in a wide range of biological processes of fungi such as Saccharomyces cerevisiae. However, systemic identification of lncRNAs in non-model fungi is a challenging task as the efficiency of rRNA ...
Xueyan Hu, Yun Zhang, Minghao Du, Ence Yang   +3 more
doaj   +1 more source

In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds

Plants, 2021
In a search for natural compounds with anti-HIV-1 activity, we studied the effect of the ethanolic extract obtained from leaves, bark, and peels of Punica granatum L.
Cinzia Sanna, Arianna Marengo, Stefano Acquadro, Alessia Caredda, Roberta Lai, Angela Corona, Enzo Tramontano, Patrizia Rubiolo, Francesca Esposito   +8 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

CATALYTIC PROPERTIES OF THE EUKARYOTIC EXOSOME [PDF]

, 2010
The eukaryotic exosome complex is built around the backbone of a 9‑subunit ring similar to phosporolytic ribonucleases such as RNase PH and polynucleotide phosphorylase (PNPase).
Séraphin, Bertrand, Chlebowski, Aleksander, Tomecki, Rafał, Gas López, Maria Eugenia, Dziembowski, Andrzej   +4 more
core  

Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains

Virology Journal, 2009
Reverse transcriptases from HIV-1 and MuLV respectively prefer Mg2+ and Mn2+ for their polymerase activity, with variable fidelity, on both RNA and DNA templates.
Pandey Virendra N, Upadhyay Alok, Talele Tanaji T   +2 more
doaj   +1 more source

Autonomously folding protein fragments reveal differences in the energy landscapes of homologous RNases H. [PDF]

PLoS ONE, 2015
An important approach to understanding how a protein sequence encodes its energy landscape is to compare proteins with different sequences that fold to the same general native structure. In this work, we compare E. coli and T.
Laura E Rosen, Susan Marqusee
doaj   +1 more source

Oligonucleotides used in RNase H assays.

, 2013
Oligonucleotides used in RNase H assays.
Martin Ciganda (313182), Noreen Williams (104699)   +1 more
core   +1 more source

Yeast RNase H(35) is the counterpart of the mammalian RNase HI, and is evolutionarily related to prokaryotic RNase HII1We dedicate this work to the memory of our colleague Robert Karwan (1959–1997).1 [PDF]

, 1998
We cloned the Saccharomyces cerevisiae homologue of mammalian RNase HI, which itself is related to the prokaryotic RNase HII, an enzyme of unknown function and previously described as having minor activity in Escherichia coli.
Braunshofer-Reiter, Christa, Peter Frank, Christa Braunshofer-Reiter, Frank, Peter, Wintersberger, Ulrike, Ulrike Wintersberger   +5 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals

Viruses, 2017
The South African national treatment programme includes nucleoside reverse transcriptase inhibitors (NRTIs) in both first and second line highly active antiretroviral therapy regimens.
Sinaye Ngcapu, Kristof Theys, Pieter Libin, Vincent C. Marconi, Henry Sunpath, Thumbi Ndung’u, Michelle L. Gordon   +6 more
doaj   +1 more source