Results 51 to 60 of about 303,152 (296)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Enzymatically Inactive Virion-Incorporated HA-A3G Is Activated by Viral RNase H

, 2013
(A) Recombinant RTs containing either a WT or mutant (E478Q) RNase H catalytic domain were assessed for RNase H activity in vitro in the absence or presence of the RNase H inhibitor Compound I (final concentration of 1, 10, or 100 μM).
Warner C Greene (67961), Vanessa B Soros (68560), Wes Yonemoto (68561)   +2 more
core   +1 more source

Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains

Virology Journal, 2009
Reverse transcriptases from HIV-1 and MuLV respectively prefer Mg2+ and Mn2+ for their polymerase activity, with variable fidelity, on both RNA and DNA templates.
Pandey Virendra N, Upadhyay Alok, Talele Tanaji T   +2 more
doaj   +1 more source

Efficient and specific DNA oligonucleotide rRNA probe-based rRNA removal in Talaromyces marneffei

Mycology, 2022
Emerging evidence showed that lncRNAs play important roles in a wide range of biological processes of fungi such as Saccharomyces cerevisiae. However, systemic identification of lncRNAs in non-model fungi is a challenging task as the efficiency of rRNA ...
Xueyan Hu, Yun Zhang, Minghao Du, Ence Yang   +3 more
doaj   +1 more source

CATALYTIC PROPERTIES OF THE EUKARYOTIC EXOSOME [PDF]

, 2010
The eukaryotic exosome complex is built around the backbone of a 9‑subunit ring similar to phosporolytic ribonucleases such as RNase PH and polynucleotide phosphorylase (PNPase).
María Eugenia Gas López, Bertrand Séraphin, Andrzej Dziembowski, Dziembowski, A, Gas López, Maria Eugenia, Dziembowski, Andrzej, Tomecki, R, Gas Lopez, Maria, Séraphin, Bertrand, Chlebowski, Aleksander, Tomecki, Rafał, Aleksander Chlebowski, Rafał Tomecki, Chlebowski, A   +13 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals

Viruses, 2017
The South African national treatment programme includes nucleoside reverse transcriptase inhibitors (NRTIs) in both first and second line highly active antiretroviral therapy regimens.
Sinaye Ngcapu, Kristof Theys, Pieter Libin, Vincent C. Marconi, Henry Sunpath, Thumbi Ndung’u, Michelle L. Gordon   +6 more
doaj   +1 more source

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

Molecules, 2020
Despite great efforts have been made in the prevention and therapy of human immunodeficiency virus (HIV-1) infection, however the difficulty to eradicate latent viral reservoirs together with the emergence of multi-drug-resistant strains require the ...
Jenny Desantis, Serena Massari, Angela Corona, Andrea Astolfi, Stefano Sabatini, Giuseppe Manfroni, Deborah Palazzotti, Violetta Cecchetti, Christophe Pannecouque, Enzo Tramontano, Oriana Tabarrini   +10 more
doaj   +1 more source

Autonomously folding protein fragments reveal differences in the energy landscapes of homologous RNases H. [PDF]

PLoS ONE, 2015
An important approach to understanding how a protein sequence encodes its energy landscape is to compare proteins with different sequences that fold to the same general native structure. In this work, we compare E. coli and T.
Laura E Rosen, Susan Marqusee
doaj   +1 more source

Chemically modified oligonucleotides with efficient RNase H response

, 2008
Udgivelsesdato: Apr-1Ten different chemically modified nucleosides were incorporated into short DNA strands (chimeric oligonucleotides ON3-ON12 and ON15-ON24) and then tested for their capacity to mediate RNAse H cleavage of the complementary RNA strand.
Lobedanz, Sune, Boel, Anne Marie, Nielsen, Poul; id_orcid, Raunak, Kumar, Surender, Wengel, Jesper, Vester, Birte, Højland, Torben, Lindegaard, Dorthe, Hrdlicka, Patrick J, Raunkjaer, Michael, Babu, B Ravindra, Sharma, Pawan K   +12 more
core   +1 more source