Results 1 to 10 of about 61,817 (251)

Thermal adaptation of conformational dynamics in ribonuclease H. [PDF]

PLoS Computational Biology, 2013
The relationship between inherent internal conformational processes and enzymatic activity or thermodynamic stability of proteins has proven difficult to characterize. The study of homologous proteins with differing thermostabilities offers an especially
Kate A Stafford, Paul Robustelli, Arthur G Palmer   +2 more
doaj   +6 more sources

The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes. [PDF]

PLoS Pathogens, 2013
Nucleos(t)ide analog therapy blocks DNA synthesis by the hepatitis B virus (HBV) reverse transcriptase and can control the infection, but treatment is life-long and has high costs and unpredictable long-term side effects.
John E Tavis, Xiaohong Cheng, Yuan Hu, Michael Totten, Feng Cao, Eleftherios Michailidis, Rajeev Aurora, Marvin J Meyers, E Jon Jacobsen, Michael A Parniak, Stefan G Sarafianos   +10 more
doaj   +5 more sources

Atomistic details of the phosphodiester cleavage of ribonuclease H [PDF]

Journal of Cheminformatics, 2011
it catalyzes the hydrolysis of phospho-diester linkages of the RNA strand in the DNA:RNAhybrid duplex. RNase H activity is encoded as a part ofthe reverse transcriptase (RT) that converts a retroviralsingle strained RNA genome into double strained DNA.Due to the RNase H activity in HIV reverse transcrip-tase (HIV-RT), it represents a promising target ...
Elsässer B, Fels G
doaj   +3 more sources

The catalytic mechanism, metal dependence, substrate specificity, and biodiversity of ribonuclease H [PDF]

Frontiers in Microbiology, 2022
Ribonucleoside monophosphates are inevitably misincorporated into the DNA genome inside cells, and they need to be excised to avoid chromosome instability.
Jing Pang, Qinyu Guo, Zheng Lu
doaj   +2 more sources

Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication [PDF]

Viruses, 2023
Viral replication often depends on RNA maturation and degradation processes catalyzed by viral ribonucleases, which are therefore candidate targets for antiviral drugs.
Abhishek Asthana, Angela Corona, Woo-Jin Shin, Mi-Jeong Kwak, Christina Gaughan, Enzo Tramontano, Jae U. Jung, Rainer Schobert, Babal Kant Jha, Robert H. Silverman, Bernhard Biersack   +10 more
doaj   +2 more sources

The folding and unfolding behavior of ribonuclease H on the ribosome [PDF]

Journal of Biological Chemistry, 2020
ABSTRACT The health of a cell depends on accurate translation and proper protein folding; misfolding can lead to aggregation and disease. The first opportunity for a protein to fold occurs during translation, when the ribosome and surrounding environment can affect the energy landscape of the nascent chain.
Jensen, Madeleine K., Samelson, Avi J., Steward, Annette, Clarke, Jane, Marqusee, Susan   +4 more
openaire   +5 more sources

Discovery of bimodal hepatitis B virus ribonuclease H and capsid assembly inhibitors. [PDF]

PLoS Pathogens
Hepatitis B virus (HBV) ribonuclease H (RNaseH) inhibitors are a potent class of antivirals that prevent degradation of the viral pregenomic RNA during reverse transcription and block formation of mature HBV DNAs.
Daniel P Bradley, Caleb J Valkner, Qilan Li, Makafui Gasonoo, Marvin J Meyers, Georgia-Myrto Prifti, Dimitrios Moianos, Grigoris Zoidis, Adam Zlotnick, John E Tavis   +9 more
doaj   +2 more sources

Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases [PDF]

Molecules
There is a strong demand for new and efficient antiviral compounds. A series of 2-hydroxy-1,4-naphthoquinone Mannich bases were screened for their HIV-1-RNase H inhibitory activity.
Nhat Quang Tu, Clémence Richetta, Federica Putzu, Olivier Delelis, Khursheed Ahmed, Vijay H. Masand, Rainer Schobert, Enzo Tramontano, Angela Corona, Bernhard Biersack   +9 more
doaj   +2 more sources

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity [PDF]

Molecules, 2020
Despite great efforts have been made in the prevention and therapy of human immunodeficiency virus (HIV-1) infection, however the difficulty to eradicate latent viral reservoirs together with the emergence of multi-drug-resistant strains require the ...
Jenny Desantis, Serena Massari, Angela Corona, Andrea Astolfi, Stefano Sabatini, Giuseppe Manfroni, Deborah Palazzotti, Violetta Cecchetti, Christophe Pannecouque, Enzo Tramontano, Oriana Tabarrini   +10 more
doaj   +2 more sources

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The paper focussed on a step-by-step structural modification of a cycloheptathiophene-3-carboxamide derivative recently identified by us as reverse transcriptase (RT)-associated ribonuclease H (RNase H) inhibitor.
Serena Massari, Angela Corona, Simona Distinto, Jenny Desantis, Alessia Caredda, Stefano Sabatini, Giuseppe Manfroni, Tommaso Felicetti, Violetta Cecchetti, Christophe Pannecouque, Elias Maccioni, Enzo Tramontano, Oriana Tabarrini   +12 more
doaj   +2 more sources