Results 21 to 30 of about 11,347,920 (284)

Sensing Ribonuclease H Activity with DNA Nanoswitches [PDF]

, 2020
Ribonuclease H (RNase H) is a damage-repair protein and ribonuclease that specifically catalyzes the hydrolysis of RNA in an RNA/DNA duplex and breaks down RNA/DNA junctions.
Trivedi, Ruju
core   +1 more source

Production of ovine Pancreatic Ribonuclease and investigation of enzyme characteristics [PDF]

پژوهشهای علوم دامی ایران, 2021
Introduction Obviously, the recent decades strategy in cancer therapy, anticancer drug discovery and drug improvement is to characterize, distinguish and validate the most promising cancer-related molecular targets to which new drugs can be designed. The
mahsa Zabetian, Mohammad reza Nasiri, Ali Javadmannesh, Shahrokh ghovati   +3 more
doaj   +1 more source

Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors. [PDF]

ChemMedChem, 2016
Despite the significant progress achieved with combination antiretroviral therapy in the fight against human immunodeficiency virus (HIV) infection, the difficulty to eradicate the virus together with the rapid emergence of multidrug-resistant strains ...
Corona A, Desantis J, Massari S, Distinto S, Masaoka T, Sabatini S, Esposito F, Manfroni G, Maccioni E, Cecchetti V, Pannecouque C, Le Grice SF, Tramontano E, Tabarrini O.   +13 more
europepmc   +2 more sources

The effect of ribonuclease on phage-host interaction [PDF]

, 1954
SUMMARY: Pancreatic ribonuclease inhibits the multiplication of a Rhizobium bacteriophage in liquid bacterial cultures by preventing permanent combination between phage and host.
Kleczkowski, A.
core   +1 more source

The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition [PDF]

, 2008
The degradation of the poly(A) tail is crucial for posttranscriptional gene regulation and for quality control of mRNA. Poly(A)-specific ribonuclease (PARN) is one of the major mammalian 3’ specific exo-ribonucleases involved in the degradation of the ...
Naohiro Kobayashi, Shirouzu, Mikako, Sakura Suzuki, Nagata, Takashi, Yoshihide Hayashizaki, Takashi Nagata, Yutaka Muto, Takanori Kigawa, Kobayashi, Naohiro, Peter Güntert, Mikako Shirouzu, Muto, Yutaka, Akiko Tanaka, Endo, Ryuta, Makoto Inoue, Hayashizaki, Yoshihide, Terada, Takaho, Inoue, Makoto, Kigawa, Takanori, Suzuki, Sakura, Yokoyama, Shigeyuki, Takaho Terada, Ryuta Endo, Shigeyuki Yokoyama, Güntert, Peter, Tanaka, Akiko   +25 more
core   +2 more sources

Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants

Viruses, 2020
HIV-1 infection requires life-long treatment and with 2.1 million new infections/year, faces the challenge of an increased rate of transmitted drug-resistant mutations.
Angela Corona, Ester Ballana, Simona Distinto, Dominga Rogolino, Claudia Del Vecchio, Mauro Carcelli, Roger Badia, Eva Riveira-Muñoz, Francesca Esposito, Cristina Parolin, José A. Esté, Nicole Grandi, Enzo Tramontano   +12 more
doaj   +1 more source

Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions

Molecules, 2021
Current therapeutic protocols for the treatment of HIV infection consist of the combination of diverse anti-retroviral drugs in order to reduce the selection of resistant mutants and to allow for the use of lower doses of each single agent to reduce ...
Rita Meleddu, Angela Corona, Simona Distinto, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Daniela Secci, Alessia Onali, Erica Sanna, Francesca Esposito, Italo Cirone, Francesco Ortuso, Stefano Alcaro, Enzo Tramontano, Péter Mátyus, Elias Maccioni   +15 more
doaj   +1 more source

Influence of gibberellic acid on hydrolytic enzymes activity in germinating different-aged lupin seeds

Acta Societatis Botanicorum Poloniae, 2015
The influence of GA3 -on the germination of different-aged lupin seed and α-amylase, protease and ribonuclease activity in the embryonic axis and cotyledons of these seeds were investigated after 24, 48, 72 and 96 h of germination. GA3 treatment of older
T. Mierzwińska
doaj   +1 more source

Antiviral Ranpirnase TMR-001 Inhibits Rabies Virus Release and Cell-to-Cell Infection In Vitro

Viruses, 2020
Currently, no rabies virus-specific antiviral drugs are available. Ranpirnase has strong antitumor and antiviral properties associated with its ribonuclease activity.
Todd G. Smith, Felix R. Jackson, Clint N. Morgan, William C. Carson, Brock E. Martin, Nadia Gallardo-Romero, James A. Ellison, Lauren Greenberg, Thomas Hodge, Luis Squiquera, Jamie Sulley, Victoria A. Olson, Christina L. Hutson   +12 more
doaj   +1 more source

Ribonuclease H Renaturation Gel Assay Using a Fluorescent-Labeled Substrate

BioTechniques, 1997
Ribonucleases H (RNases H) are enzymes that specifically degrade the RNA of RNA-DNA hybrids. These enzymes are involved in DNA replication, reverse transcription (RT) and antisense oligodeoxyribonucleotide-mediated arrest of translation.
Li-Ying Han, Wu-Po Ma, Robert J. Crouch
doaj   +1 more source