Results 21 to 30 of about 171,175 (241)

WO 2014203008 A1 Antisense oligonucleotide compositions

, 2014
The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of antisense oligonucleotides (ASOs).
Mitchell, John, Richardson, Simon, Dyer, Paul D.R.   +2 more
core   +6 more sources

Identification of sequence motifs significantly associated with antisense activity

BMC Bioinformatics, 2007
Background Predicting the suppression activity of antisense oligonucleotide sequences is the main goal of the rational design of nucleic acids. To create an effective predictive model, it is important to know what properties of an oligonucleotide ...
Peek Andrew S, McQuisten Kyle A
doaj   +1 more source

How late is too late for treatment?

eLife, 2023
Experiments on mice suggest that an approach called antisense oligonucleotide therapy may be able to treat some symptoms of Angelman syndrome, including problems with epilepsy and sleep.
Lawrence T Reiter
doaj   +1 more source

Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues [PDF]

, 2009
Background: More than 20% of human transcripts have naturally occurring antisense products (or natural antisense transcripts – NATs), some of which may play a key role in a range of human diseases.
Oliver, G.R., Kendrick, H., Jat, P., Oliver, Gavin, Neville, A.M., Gavin R Oliver, Howard Kendrick, Tanney, Austin, Tanney, A., Grigoriadis, A., Grigoriadis, Anita, Smalley, M.J., Austin Tanney, Anita Grigoriadis, Kendrick, Howard, Jat, Parmjit, Matt J Smalley, A Munro Neville, Neville, A. Munro, Parmjit Jat, Smalley, Matthew John   +20 more
core   +1 more source

CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity [PDF]

, 2012
In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.
Franch i Masferrer, Àngels, Ciudad i Gómez, Carlos Julián, Castellote i Bargalló, M. Cristina, Castell, Margarida, Noé Mata, Verónica, Rabanal i Tornero, Manel, Pelegrí i Gabaldà, Carme   +6 more
core   +1 more source

The targeted delivery of anti-metastasis oligonucleotide in breast cancer cells by the nanoliposomes conjugated with RGD ligand

Advances in Cancer Biology - Metastasis
To decrease the ETV4 gene, which is important in metastasis, the nanoliposome containing ETV4 antisense oligonucleotide conjugated with Arginylglycylaspartic acid (RGD) ligand was used in the study.
Farahanaz Kavian Manesh, Ali Jebali, Flora Forouzesh   +2 more
doaj   +1 more source

Synthesis and anti-HIV activity of thiocholesteryl-coupled phosphodiester antisense oligonucleotides incorporated into immunoliposomes [PDF]

, 1994
Encapsulation of oligonucleotides in antibody-targeted liposomes (immunoliposomes) which bind to target cells permits intracellular delivery of the oligonucleotides.
Zelphati, Olivier, Leserman, Lee, Wagner, Ernst   +2 more
core   +1 more source

Antisense Therapy for Infectious Diseases

Cells, 2023
Infectious diseases, particularly Tuberculosis (TB) caused by Mycobacterium tuberculosis, pose a significant global health challenge, with 1.6 million reported deaths in 2021, making it the most fatal disease caused by a single infectious agent. The rise
Lwanda Abonga Buthelezi, Shandre Pillay, Noxolo Nokukhanya Ntuli, Lorna Gcanga, Reto Guler   +4 more
doaj   +1 more source

A Tandem Oligonucleotide Approach for SNP-Selective RNA Degradation Using Modified Antisense Oligonucleotides. [PDF]

PLoS ONE, 2015
Antisense oligonucleotides have been studied for many years as a tool for gene silencing. One of the most difficult cases of selective RNA silencing involves the alleles of single nucleotide polymorphisms, in which the allele sequence is differentiated ...
Dorota Magner, Ewa Biala, Jolanta Lisowiec-Wachnicka, Elzbieta Kierzek, Ryszard Kierzek   +4 more
doaj   +1 more source

Antisense oligonucleotide based therapeutics and its applications against bacterial infections

Medicine in Drug Discovery, 2023
The transcriptome of a cell governs the overall cellular expression of proteins, hence, targeting mRNA holds promise as a therapeutic strategy in the field of drug discovery.
Nupur Angrish, Garima Khare
doaj   +1 more source