Results 121 to 130 of about 102,021 (242)

When <i>HERG</i>-caused LQT2 encounters antisense oligonucleotide: is exon 6 skipping therapy plausible? [PDF]

Front Pharmacol
Zheng Z, Song Y.
europepmc   +1 more source

Steroid‐Modulated Transcription Synergistically Forms DNA Double‐Strand Breaks With Topoisomerase II Inhibitor

Cancer Science, EarlyView.
Through our exploration of the synergistic effects of drug combinations for potential clinical applications, we found that steroids potentiate the anticancer effects of etoposide, a topoisomerase II inhibitor. Steroids, when combined with etoposide, increase DNA double‐strand breaks not via DNA repair inhibition but transcriptional modulation ...
Ying Zhao, Tetsuro Hisayoshi, Doudou Zhang, Saaya Suzuki, Takashi Watanabe, Atsuo Kobayashi, Qianqian Guo, Yukihide Momozawa, Takashi Shimokawa, Shunsuke Kato, Yoshio Miki, Shigeaki Sunada   +11 more
wiley   +1 more source

Systematic analysis of genetic and phenotypic characteristics reveals antisense oligonucleotide therapy potential for one-third of neurodevelopmental disorders. [PDF]

Genome Med
Wijnant KN, Nadif Kasri N, Vissers LELM.
europepmc   +1 more source

Longitudinal Visual Biomarkers in Dominant Optic Atrophy: A Systematic Review and Meta‐Analysis

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Dominant Optic Atrophy (DOA) causes slowly progressive visual decline usually beginning in childhood. As new therapies come to clinical trial, the choice of biomarkers to be used as clinical trial endpoints has become a critical question to be addressed. Methods We undertook a systematic review and meta‐analysis of studies reporting
Christopher A. Ovens, John R. Grigg, Clare L. Fraser   +2 more
wiley   +1 more source

Robust Photocleavable Linkers for DNA Synthesis: Enabling Visible Light-Triggered Antisense Oligonucleotide Release in 3D DNA Nanocages. [PDF]

Biomacromolecules
Leung HM, Chan HY, Klimezak M, Liu LS, Karam P, Specht A, Bolze F, Lo PK.   +7 more
europepmc   +1 more source

SLC30A4‐AS1 Mediates the Senescence of Periodontal Ligament Stem Cells in Inflammatory Environments via the Alternative Splicing of TP53BP1

Cell Proliferation, Volume 58, Issue 4, April 2025.
Briefly, SLC30A4‐AS1 is upregulated in senescent PDLSCs mediated by inflammation. SLC30A4‐AS1 binds the splicing factor SRSF3 to affect the alternative splicing of TP53BP1 and alter the expression of its transcript TP53BP1‐204. Knockdown of TP53BP1‐204 expression can improve the senescence of PDLSCs and improve the osteogenic differentiation ability of
Mei Xu, Dian Gan, Xi‐Yu Zhang, Xiao‐Tao He, Rui Xin Wu, Yuan Yin, Rui Jin, Lin Li, Yu‐Jie Tan, Fa‐Ming Chen, Xuan Li, Bei‐Min Tian   +11 more
wiley   +1 more source

Evaluation of an Antisense Oligonucleotide Targeting CAG Repeats: A Patient-Customized Therapy Study for Huntington's Disease. [PDF]

Life (Basel)
Ocampo-Ortega SA, Sierra-Sanchez VM, Blancas-Napoles CM, González-Carteño A, Mera-Jiménez E, Macías-Pérez ME, Hernandez-Guerra A, Romero-Nava R, Huang F, Hong E, Villafaña S.   +10 more
europepmc   +1 more source

Why, how and in whom should we measure levels of lipoprotein(a): A review of the latest evidence and clinical implications

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Lipoprotein(a) [Lp(a)] is a genetically determined, causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve disease (CAVD). Despite robust evidence from epidemiological and genetic studies, Lp(a) remains underrecognised in clinical practice due to challenges in measurement, lack of guideline familiarity ...
Alexander C. Razavi, Harpreet S. Bhatia, Roger S. Blumenthal, Michael D. Shapiro, Anurag Mehta   +4 more
wiley   +1 more source

Sodium‐glucose cotransporter 2 inhibitors and outcomes in transthyretin amyloid cardiomyopathy: Systematic review and meta‐analysis

European Journal of Clinical Investigation, Volume 55, Issue 6, June 2025.
Patients with transthyretin amyloid cardiomyopathy (ATTR‐CM) were excluded from randomized clinical trials (RCTs) evaluating sodium‐glucose cotransporter 2 inhibitors (SGLT2i); as a result, the effects of these agents on this population remain underexplored.
Paschalis Karakasis, Panagiotis Theofilis, Dimitrios Patoulias, Art Schuermans, Panayotis K Vlachakis, Aleksandra Klisic, Manfredi Rizzo, Nikolaos Fragakis   +7 more
wiley   +1 more source

Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells [PDF]

Mol Ther Nucleic Acids
Suzuki N.
europepmc   +2 more sources