Results 121 to 130 of about 94,605 (281)

Delivery of Antisense Oligonucleotides Using the Nano‐Cell Vesicle Technology System (nCVTs) for Targeted Cancer Therapy

Small, EarlyView.
Nano‐Cell Vesicle Technology (nCVTs) integrates cationic lipids with tumor‐homing cell membranes to achieve efficient intracellular transport of antisense oligonucleotides. The system enhances nuclear delivery, minimizes cytotoxicity, and suppresses tumor growth in vivo, establishing nCVTs as a versatile and biocompatible platform for next‐generation ...
Yi Hsuan Ou, Wei Heng Chng, Ram Pravin Kumar Muthuramalingam, Prathyusha Raghunathan, Nichakan Khunkitchai, Choon Keong Lee, Jae Ha Jun, Zi Xiu Ng, Phua Tian Xin, Wei Jiang Goh, Jiong‐Wei Wang, Bertrand Czarny   +11 more
wiley   +1 more source

Antisense oligonucleotides to class III β-tubulin sensitize drug-resistant cells to Taxol [PDF]

, 1999
Maria Kavallaris, Catherine A. Burkhart, Susan Band Horwitz   +2 more
openalex   +1 more source

Full‐length transcriptome profiling of true bug mitochondrial genomes reveals the unique transcriptional regulation during insect evolution

Insect Science, EarlyView.
The mitogenome was transcribed into complete primary polycistrons on both strands. The heteropteran mitochondrial transcription termination factor (HmTTF) functions as a bidirectional attenuator rather than a terminator, and co‐evolution of HmTTF and the binding sites was observed.
Shiwen Xu, Yuange Duan, Ling Ma, Qiaoqiao Liu, Fan Song, Wanzhi Cai, Hu Li   +6 more
wiley   +1 more source

Histopathological Characterization and Differential Expression of miRNAs in Male Pediatric Patients With Lichen Sclerosus

Andrology, EarlyView.
ABSTRACT Background Lichen sclerosus is a chronic, inflammatory, scarring disease of the skin that manifests mostly in the genital region. Objective We studied the histomorphological characteristics, grade, and pattern of inflammation in male pediatric patients with lichen sclerosus.
Valerie Flammang, Arndt Hartmann, Robert Stöhr, Katrin Weigelt, Carol Geppert, Frederik A. Stuebs, Matthias W. Beckmann, Bernd Wullich, Helge Taubert, Marios Marcou, Sven Wach   +10 more
wiley   +1 more source

Antisense oligonucleotide‐based α‐synuclein targeting as a disease‐modifying treatment for Dementia with Lewy bodies (DLB) disease [PDF]

Rijwan Uddin Ahammad, Brian Spencer, Andre D. G. Leitao, Robert A. Rissman   +3 more
openalex   +1 more source

Intrathecal administration of Ca_v3.2 and Ca_v3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion [PDF]

, 2006
Xianjie Wen, Zhang-jun LI, Zhi‐Xin Chen, Zhiyuan Fang, Yang Chenxiang, Heng Li, Zeng Yin-ming   +6 more
openalex   +1 more source

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

Identification and characterization by antisense oligonucleotides of exon and intron sequences required for splicing.

, 2020
Z Dominski, R Kole
openalex   +1 more source

c-kit expression by CD34+ bone marrow progenitors and inhibition of response to recombinant human interleukin-3 following exposure to c-kit antisense oligonucleotides [PDF]

, 1991
JP Catlett, JA Leftwich, EH Westin, Steven Grant, TF Huff   +4 more
openalex   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, EarlyView.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source