Results 261 to 270 of about 263,255 (408)

Cadherin‐6 controls neuronal migration during mouse neocortical development via an integrin‐mediated pathway

The FEBS Journal, EarlyView.
Neuronal migration plays essential roles in the establishment of mammalian brains, and its impairment causes severe developmental abnormalities and behavioral and cognitive deficits. Here, we report that cadherin‐6 (CDH6), an unusual cadherin molecule containing an RGD integrin‐binding motif in the first extracellular domain, controls the motility of ...
Yuki Hirota, Rikaho Saito, Takao Honda, Hitomi Sano, Mayuko Hotta, Yukiko U. Inoue, Takayoshi Inoue, Kazunori Nakajima   +7 more
wiley   +1 more source

Prothymosin α antisense oligonucleotides induce apoptosis in HL-60 cells [PDF]

, 1999
Pilar Rodriguez Rodrí­guez, Juan E. Viñuela, Leoncio Álvarez-Fernández, Jaime Gómez‐Márquez   +3 more
openalex   +1 more source

Alternative Splicing Regulation in Metabolic Disorders

Obesity Reviews, EarlyView.
ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley   +1 more source

Molecular genetics of development studied in the transgenic mouse. [PDF]

, 1989
Gruss, P., Westphal, H.
core   +2 more sources

Natural variation of CsUGT71A60 determines growth and cold tolerance via regulating cytokinin glycosylation in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
Summary Cold stress severely limits tea plant (Camellia sinensis) productivity, yet the molecular mechanisms underlying cold adaptation remain elusive. Here, we identified a cold‐inducible glycosyltransferase, CsUGT71A60, through integrative genome‐wide association studies (GWAS) and proteomic profiling.
Mingyue Zhao, Jingming Wang, Xinyuan Hao, Jieyang Jin, Junwei Tang, Yueyue Wang, Mengting Zhang, Tingting Jing, Wilfried Schwab, Ting Gao, Xinchao Wang, Chuankui Song   +11 more
wiley   +1 more source

Systematic analysis of genetic and phenotypic characteristics reveals antisense oligonucleotide therapy potential for one-third of neurodevelopmental disorders. [PDF]

Genome Med
Wijnant KN, Nadif Kasri N, Vissers LELM.
europepmc   +1 more source

CsMYB213‐CsbHLH35 module regulates theanine biosynthesis in tea plants (Camellia sinensis L.)

Plant Biotechnology Journal, EarlyView.
Summary Theanine is a non‐protein free amino acid accumulated in tea plant leaves and makes a major contribution to the unique umami and sweet taste and a multitude of human health benefits of tea. However, its biosynthesis and transcriptional regulation in tea plant leaves remain to be fully understood.
Nianci Xie, Pinqian Zhou, Kuofei Wang, Feiyi Huang, Shuwei Yu, Haiping Fu, Saijun Li, Juan Li, Jian Zhao, Zhonghua Liu, Kunbo Wang   +10 more
wiley   +1 more source

Robust Photocleavable Linkers for DNA Synthesis: Enabling Visible Light-Triggered Antisense Oligonucleotide Release in 3D DNA Nanocages. [PDF]

Biomacromolecules
Leung HM, Chan HY, Klimezak M, Liu LS, Karam P, Specht A, Bolze F, Lo PK.   +7 more
europepmc   +1 more source

A natural variation in the promoter of TaGDSL‐7D contributes to grain weight and yield in wheat

Plant Biotechnology Journal, EarlyView.
Summary Grain weight (GW) is a critical agronomic trait that greatly impacts wheat yield, yet the underlying genetic factors remain largely unknown. Here, we identify and characterize a candidate gene TaGDSL‐7D controlling GW in wheat through map‐based cloning, which encodes an ER‐located GDSL‐family protein.
Fei He, Dejie Du, Zhaoyan Chen, Liang Ma, Yunjie Liu, Zhaoju Li, Long Song, Zihao Jiang, Yujie Fan, Qixin Sun, Zhongfu Ni   +10 more
wiley   +1 more source

Evaluation of an Antisense Oligonucleotide Targeting CAG Repeats: A Patient-Customized Therapy Study for Huntington's Disease. [PDF]

Life (Basel)
Ocampo-Ortega SA, Sierra-Sanchez VM, Blancas-Napoles CM, González-Carteño A, Mera-Jiménez E, Macías-Pérez ME, Hernandez-Guerra A, Romero-Nava R, Huang F, Hong E, Villafaña S.   +10 more
europepmc   +1 more source