Results 301 to 310 of about 266,614 (380)

Molecular mechanisms and antisense oligonucleotide therapies of familial amyotrophic lateral sclerosis. [PDF]

Mol Ther Nucleic Acids
Al Dera H, AlQahtani B.
europepmc   +1 more source

Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
The top row shows key drivers‐KRAS, c‐Myc and HIF‐1a‐alongside gut and tumor microbiota, all converging on glutamine metabolism in PDAC. At the center, glutamine handling is depicted as the linchpin of tumor growth, biosynthesis and immune modulation. The green panel lists major intervention strategies: DON‐loaded nanoparticles, prodrugs (DRP‐104/JHU ...
Min Su, Huan Qin, Jie Shen, Hao An, Yu Cao   +4 more
wiley   +1 more source

Beyond linear: How circRNAs twist and turn Notch signaling

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
Circular RNAs have crucial functions in the regulation of the Notch pathway. They mainly regulate this pathway through modulation of NOTCH 1, NOTCH 2, and NOTCH 3. Jagged and DLL transcripts are also regulated by circular RNAs. Abstract Circular RNAs (circRNAs) have emerged as pivotal regulators of the Notch signaling pathway, influencing diverse ...
Pegah Yazdan Panah, Amir Sadeghi, Soudeh Ghafouri‐Fard   +2 more
wiley   +1 more source

Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects. [PDF]

Nat Commun
Leclair NK, Brugiolo M, Park S, Devoucoux M, Urbanski L, Angarola BL, Yurieva M, Anczuków O.   +7 more
europepmc   +1 more source

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

Medicinal Research Reviews, Volume 45, Issue 5, Page 1423-1451, September 2025.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel   +3 more
wiley   +1 more source

Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia, Ziyu Wei, Jinyuan Luoqian, Xi Wang, Chao Huang   +4 more
wiley   +1 more source

Deep learning facilitates efficient optimization of antisense oligonucleotide drugs. [PDF]

Mol Ther Nucleic Acids
Lin S, Hong L, Wei DQ, Xiong Y.
europepmc   +1 more source

Recent Progress in Gene Delivery Systems Based on Gemini‐Surfactant

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Gene delivery is a key area in biomedicine, where nucleic acids are delivered into cells to treat diseases by modulating genes. The low micelle concentration, effective nucleic acid complexation, and low immunogenicity make Gemini surfactants promising gene delivery vectors.
Peng Qian, Yuxin Chen, Yangchen Xing, Kexin Wu, Qianyu Zhang, Huali Chen   +5 more
wiley   +1 more source

Antisense oligonucleotide therapeutic approach for Timothy syndrome. [PDF]

Nature
Chen X, Birey F, Li MY, Revah O, Levy R, Thete MV, Reis N, Kaganovsky K, Onesto M, Sakai N, Hudacova Z, Hao J, Meng X, Nishino S, Huguenard J, Pașca SP.   +15 more
europepmc   +1 more source

Zebrafish as a Versatile Model Organism: From Tanks to Treatment

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
The zebrafish, with its optical transparency and genetic tractability, serves as a versatile in vivo platform for biomedical research. This review underscores its significance in modeling a wide spectrum of human diseases—from cancer to metabolic disorders—and in leveraging cutting‐edge technologies like CRISPR and TALENs.
Rupali Srivastava, Kalyani Eswar, Sasvat Sayee Ram Ramesh, Akshit Prajapati, Tanvi Sonpipare, Apoorva Basa, Mounika Gubige, Sribala Ponnapalli, Shashidhar Thatikonda, Aravind Kumar Rengan   +9 more
wiley   +1 more source