Results 331 to 340 of about 263,255 (408)

Nanotechnology in brain cancer treatment: The role of gold nanoparticles as therapeutic enhancers

Ibrain, Volume 11, Issue 2, Page 119-145, Summer 2025.
This review highlights the potential of gold nanoparticles (AuNPs) in overcoming the blood‐brain barrier (BBB) to improve brain tumor treatment. By enabling targeted drug delivery and enhancing therapies like radiotherapy, phototherapy, and chemotherapy, AuNPs offer a promising approach for safer, more effective treatments of glioblastoma and other ...
Simona Tarantino, Annalisa Bianco, Valeria De Matteis, Edoardo Scarpa, Rosaria Rinaldi   +4 more
wiley   +1 more source

l-Type amino acid transporter 1-targeting nanoparticles for antisense oligonucleotide delivery to the CNS. [PDF]

Mol Ther Nucleic Acids
Lim YN, Ryu IS, Jung YJ, Helmlinger G, Kim I, Park HW, Kang H, Lee J, Lee HJ, Lee KS, Jang HN, Ha DI, Park J, Won J, Lim KS, Jeon CY, Cho HJ, Min HS, Ryu JH.   +18 more
europepmc   +1 more source

Beyond Conventional Approaches: The Revolutionary Role of Nanoparticles in Breast Cancer

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
This review explores integrated approach of nanotechnology to breast cancer diagnosis and treatment. We highlight imaging techniques for tumor detection and biomarker analysis in biological samples for early diagnosis. Advanced therapies, including targeted drug delivery and antibody‐drug conjugates, enable precise medication transport to cancer cells,
Mohan Liu, Yusi Wang, Yan Li, Yibing Zhang, Bailing Zhou, Lei Yang, Xi Yan, Li Yang   +7 more
wiley   +1 more source

Treatability of the KMT2-Associated Neurodevelopmental Disorders Using Antisense Oligonucleotide-Based Treatments. [PDF]

Hum Mutat
Zardetto B, van Roon-Mom W, Aartsma-Rus A, Lauffer MC.   +3 more
europepmc   +1 more source

Loss of Adenosine Deaminase Acting on RNA 1 Induces Panoptosis and Immune Response in Ulcerative Colitis Gut Mucosa

MedComm, Volume 6, Issue 6, June 2025.
The gut virome is a complex community that, when disrupted, may contribute to inflammatory diseases like IBD. We found that ADAR1 expression is reduced in gut inflamed mucosa of ulcerative colitis patients. ADAR1 silencing heightened activation of inflammatory pathways and PANoptosis exacerbating gut tissue damage, but JAK inhibition or AhR activation ...
Andrea Iannucci, Marco Colella, Macarena Quiroga, Rachele Frascatani, Lorenzo Tomassini, Claudia Maresca, Eleonora Franzè, Federica Laudisi, Giuseppe Sica, Irene Marafini, Alessandro Michienzi, Ivan Zanoni, Giovanni Monteleone, Ivan Monteleone   +13 more
wiley   +1 more source

Mechanisms of Action of the US Food and Drug Administration-Approved Antisense Oligonucleotide Drugs. [PDF]

BioDrugs
Sang A, Zhuo S, Bochanis A, Manautou JE, Bahal R, Zhong XB, Rasmussen TP.   +6 more
europepmc   +1 more source

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

MedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu, Shiyuan Huang, Li Peng, Li Yang, Guosong Zhang, Tao Liu, Fang Yan, Xi Peng   +7 more
wiley   +1 more source

Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy. [PDF]

Chem Biomed Imaging
Liao H, Wang S, Wang X, Dai DZ, Zhang Y, Zhu C, Li J.   +6 more
europepmc   +1 more source

The Long Noncoding RNA LINC02820 Promotes Tumor Growth and Metastasis Through Regulating MYH9 Expression in Esophageal Squamous Cell Carcinoma

MedComm, Volume 6, Issue 6, June 2025.
This study demonstrates that the RNA‐binding protein IGF2BP2 binds to and stabilizes LINC02820, leading to elevated LINC02820 expression in esophageal squamous cell carcinoma (ESCC). Moreover, association of LINC02820 with MYH9 protein protects MYH9 from proteasomal degradation, thus upregulating MYH9 to promote tumor growth and metastasis in ESCC ...
Xiaomin Xu, Xinting Mao, Wenrong Liu, Yue Ming, Tingting Zhang, Yang Yang, A‐Lai Gu‐Ha, Yi‐Dan Lin, Yong Peng   +8 more
wiley   +1 more source