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ChemInform Abstract: Chemistry of Antisense Oligonucleotides
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lucius Kaufhold, Christian R. Noe
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Antisense oligonucleotides in cutaneous therapy
Pharmacology & Therapeutics, 2001Antisense oligonucleotides have been the subject of intense interest as research tools to elucidate the functions of gene products and as therapeutic agents. Initially, their mode of action was poorly understood and the biological effects of oligonucleotides were often misinterpreted.
Paul J. White, Christopher J. Wraight
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Antisense Oligonucleotides: Promise and Reality
Annual Review of Pharmacology and Toxicology, 2001Antisense oligonucleotides have been used for more than a decade to downregulate gene expression. Phosphodiester oligonucleotides are nuclease sensitive, and the more nuclease-resistant phosphorothioate oligonucleotides are now in common use in the laboratory and have entered clinical trials.
Cy A. Stein, Irina V. Lebedeva
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ACS Applied Materials and Interfaces, 2018
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA) located in the cell nucleus, is a critical regulator of tumor cell migration. Antisense oligonucleotides (ASOs), which can downregulate the expression level of
N. Gong +3 more
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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA) located in the cell nucleus, is a critical regulator of tumor cell migration. Antisense oligonucleotides (ASOs), which can downregulate the expression level of
N. Gong +3 more
semanticscholar +1 more source
Seminars in cancer biology, 1992
Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene ...
CALABRETTA, Bruno, Skorski T, Zon G.
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Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene ...
CALABRETTA, Bruno, Skorski T, Zon G.
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2006
Publisher Summary Antisense oligonucleotides (ASO) offer significant advantages over traditional methods in terms of specificity and versatility. ASOs validate the function of genes in vitro and in vivo. In addition, antisense oligonucleotides are developed as drugs with many products currently being tested in clinical trials. ASOs are short stretches
Erich Koller, Nicholas M. Dean
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Publisher Summary Antisense oligonucleotides (ASO) offer significant advantages over traditional methods in terms of specificity and versatility. ASOs validate the function of genes in vitro and in vivo. In addition, antisense oligonucleotides are developed as drugs with many products currently being tested in clinical trials. ASOs are short stretches
Erich Koller, Nicholas M. Dean
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History of Antisense Oligonucleotides
2003Biological science is a rapidly flowing experimental stream, at times encountering a dam that impedes further progress. At such a pomt, a single crack may induce a major breakthrough Discovery of the double helical structure of DNA in 1953 (1) caused such an event, with flooding of new information into the area now known as molecular biology.
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Antisense Oligonucleotide Therapy in Urology
Journal of Urology, 2002Antisense oligonucleotides are short modified DNA or RNA molecules designed to bind selectively messenger RNA and inhibit synthesis of the encoded protein. In the last 20 years antisense technology has emerged as an exciting and promising strategy, especially for treating cancer.
Ingo Kausch, A. Böhle
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Progress in Antisense Oligonucleotide Therapeutics
Annual Review of Pharmacology and Toxicology, 1996The past several years have seen substantial progress in the development of antisense oligonucleotides as pharmacological tools and as therapeutic agents. With properly designed and executed experiments, it has been possible to demonstrate selective inhibition of gene expression, owing to an antisense mechanisms of action both in cell culture-based ...
Stanley T. Crooke, C F Bennett
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Mini-antisense Oligonucleotides
Nucleosides and Nucleotides, 1997Abstract A new strategy of selective DNA target modification was proposed. The using of reactive derivatives of short oligonucleotides in the presence of flanking effector pair allows one to modify DNA target only when the perfect complementary complex of DNA target and oligonucleotide tandem is formed.
Dmitrii V. Pyshnyi +4 more
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